Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

Therapeutic blocking of the PD1 pathway results in significant tumor responses, but resistance is common. We demonstrate that prolonged interferon signaling orchestrates PDL1-dependent and PDL1-independent resistance to immune checkpoint blockade (ICB) and to combinations such as radiation plus anti...

Full description

Saved in:

Bibliographic Details
Published in:	Cell Vol. 167; no. 6; p. 1540
Main Authors:	Benci, Joseph L, Xu, Bihui, Qiu, Yu, Wu, Tony J, Dada, Hannah, Twyman-Saint Victor, Christina, Cucolo, Lisa, Lee, David S M, Pauken, Kristen E, Huang, Alexander C, Gangadhar, Tara C, Amaravadi, Ravi K, Schuchter, Lynn M, Feldman, Michael D, Ishwaran, Hemant, Vonderheide, Robert H, Maity, Amit, Wherry, E John, Minn, Andy J
Format:	Journal Article
Language:	English
Published:	United States 01.12.2016
Subjects:	Animals B7-H1 Antigen - metabolism Cell Line, Tumor CTLA-4 Antigen - antagonists & inhibitors Drug Resistance, Neoplasm Heterografts Humans Interferons - immunology Melanoma - drug therapy Melanoma - immunology Melanoma - radiotherapy Melanoma - therapy Mice Neoplasm Transplantation Radioimmunotherapy STAT1 Transcription Factor T-Lymphocytes - immunology
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!