The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses

Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can differentiate into iNKT follicular helper (iNKTfh) cells, and here, we investigate how this, in turn, regulates conventional T follicular helper (Tfh)...

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Vydané v:	Cell reports (Cambridge) Ročník 44; číslo 5; s. 115602
Hlavní autori:	He, Chenfei, Wang, Shan, Moreews, Marion, Pei, Shengduo, Chen, Guangchun, Li, Quan-Zhen, Del Monte Monge, Alberto, Ramiro, Almudena R., Cai, Curtis, Gaya, Mauro, Barral, Patricia, Buggert, Marcus, Batista, Facundo D., Karlsson, Mikael C.I.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 27.05.2025 Elsevier
Predmet:	Animals Antigens, CD1d - immunology Antigens, CD1d - metabolism apoptotic cells Autoantibodies - immunology autoimmune disease Autoimmunity B-Lymphocytes - immunology CD1d Cell Differentiation CP: Immunology germinal center Lupus Erythematosus, Systemic - immunology Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Natural Killer T-Cells - immunology T follicular helper cells T Follicular Helper Cells - immunology T-Lymphocytes, Helper-Inducer - immunology CP: Immunology CD1d germinal center apoptotic cells autoimmune disease T follicular helper cells
ISSN:	2211-1247, 2211-1247
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Abstract	Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can differentiate into iNKT follicular helper (iNKTfh) cells, and here, we investigate how this, in turn, regulates conventional T follicular helper (Tfh) cells. This is done in an autoimmune model where antibodies are produced against self-antigens relevant to the autoimmune disease systemic lupus erythematosus (SLE). We find a balance between iNKTfh and Tfh cells that directs the B cell response and influences Tfh cell generation. This altered balance also affects the specificities and increases the autoantibody response. We also show that CD1d expression by B cells is essential for iNKTfh cell generation. In conclusion, our data shed light on how T cell help for B cells is divided between conventional and unconventional helper cell populations and how this has an impact on autoreactive B cell responses. [Display omitted] •Conventional and unconventional T follicular helper cells influence each other•Autoreactive B cell responses are enhanced by the activation of iNKTfh cells•Activation of iNKTfh cells is connected to interaction with CD1d expressed by B cells In this study, He et al. find that there is a balance between conventional and unconventional T helper cells and that this influences autoreactive B cell responses. They find that when iNKTfh cells are activated, they limit the expansion of Tfh cells, but the resulting autoreactive B cell response is increased.
AbstractList	Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can differentiate into iNKT follicular helper (iNKTfh) cells, and here, we investigate how this, in turn, regulates conventional T follicular helper (Tfh) cells. This is done in an autoimmune model where antibodies are produced against self-antigens relevant to the autoimmune disease systemic lupus erythematosus (SLE). We find a balance between iNKTfh and Tfh cells that directs the B cell response and influences Tfh cell generation. This altered balance also affects the specificities and increases the autoantibody response. We also show that CD1d expression by B cells is essential for iNKTfh cell generation. In conclusion, our data shed light on how T cell help for B cells is divided between conventional and unconventional helper cell populations and how this has an impact on autoreactive B cell responses. Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can differentiate into iNKT follicular helper (iNKTfh) cells, and here, we investigate how this, in turn, regulates conventional T follicular helper (Tfh) cells. This is done in an autoimmune model where antibodies are produced against self-antigens relevant to the autoimmune disease systemic lupus erythematosus (SLE). We find a balance between iNKTfh and Tfh cells that directs the B cell response and influences Tfh cell generation. This altered balance also affects the specificities and increases the autoantibody response. We also show that CD1d expression by B cells is essential for iNKTfh cell generation. In conclusion, our data shed light on how T cell help for B cells is divided between conventional and unconventional helper cell populations and how this has an impact on autoreactive B cell responses.Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can differentiate into iNKT follicular helper (iNKTfh) cells, and here, we investigate how this, in turn, regulates conventional T follicular helper (Tfh) cells. This is done in an autoimmune model where antibodies are produced against self-antigens relevant to the autoimmune disease systemic lupus erythematosus (SLE). We find a balance between iNKTfh and Tfh cells that directs the B cell response and influences Tfh cell generation. This altered balance also affects the specificities and increases the autoantibody response. We also show that CD1d expression by B cells is essential for iNKTfh cell generation. In conclusion, our data shed light on how T cell help for B cells is divided between conventional and unconventional helper cell populations and how this has an impact on autoreactive B cell responses. Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can differentiate into iNKT follicular helper (iNKTfh) cells, and here, we investigate how this, in turn, regulates conventional T follicular helper (Tfh) cells. This is done in an autoimmune model where antibodies are produced against self-antigens relevant to the autoimmune disease systemic lupus erythematosus (SLE). We find a balance between iNKTfh and Tfh cells that directs the B cell response and influences Tfh cell generation. This altered balance also affects the specificities and increases the autoantibody response. We also show that CD1d expression by B cells is essential for iNKTfh cell generation. In conclusion, our data shed light on how T cell help for B cells is divided between conventional and unconventional helper cell populations and how this has an impact on autoreactive B cell responses. Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can differentiate into iNKT follicular helper (iNKTfh) cells, and here, we investigate how this, in turn, regulates conventional T follicular helper (Tfh) cells. This is done in an autoimmune model where antibodies are produced against self-antigens relevant to the autoimmune disease systemic lupus erythematosus (SLE). We find a balance between iNKTfh and Tfh cells that directs the B cell response and influences Tfh cell generation. This altered balance also affects the specificities and increases the autoantibody response. We also show that CD1d expression by B cells is essential for iNKTfh cell generation. In conclusion, our data shed light on how T cell help for B cells is divided between conventional and unconventional helper cell populations and how this has an impact on autoreactive B cell responses. [Display omitted] •Conventional and unconventional T follicular helper cells influence each other•Autoreactive B cell responses are enhanced by the activation of iNKTfh cells•Activation of iNKTfh cells is connected to interaction with CD1d expressed by B cells In this study, He et al. find that there is a balance between conventional and unconventional T helper cells and that this influences autoreactive B cell responses. They find that when iNKTfh cells are activated, they limit the expansion of Tfh cells, but the resulting autoreactive B cell response is increased.
ArticleNumber	115602
Author	Ramiro, Almudena R. Li, Quan-Zhen Barral, Patricia Moreews, Marion Cai, Curtis Gaya, Mauro Batista, Facundo D. Karlsson, Mikael C.I. Chen, Guangchun Del Monte Monge, Alberto Buggert, Marcus Pei, Shengduo He, Chenfei Wang, Shan
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Snippet	Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can...
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SubjectTerms	Animals Antigens, CD1d - immunology Antigens, CD1d - metabolism apoptotic cells Autoantibodies - immunology autoimmune disease Autoimmunity B-Lymphocytes - immunology CD1d Cell Differentiation CP: Immunology germinal center Lupus Erythematosus, Systemic - immunology Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Natural Killer T-Cells - immunology T follicular helper cells T Follicular Helper Cells - immunology T-Lymphocytes, Helper-Inducer - immunology
Title	The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses
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