Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage

The Sgs1-Rmi1-Top3 "dissolvasome" is required for the maintenance of genome stability and has been implicated in the processing of various types of DNA structures arising during DNA replication. Previous investigations have revealed that unprocessed (X-shaped) homologous recombination repa...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 108; H. 12; S. 4944
Hauptverfasser:	Mankouri, Hocine W, Ashton, Thomas M, Hickson, Ian D
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 22.03.2011
Schlagworte:	DNA Damage - drug effects DNA Damage - physiology DNA, Cruciform - genetics DNA, Cruciform - metabolism DNA, Fungal - genetics DNA, Fungal - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Holliday Junction Resolvases - genetics Holliday Junction Resolvases - metabolism Humans Methyl Methanesulfonate - pharmacology Mutagens - pharmacology RecQ Helicases - genetics RecQ Helicases - metabolism S Phase - drug effects S Phase - physiology Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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