Long noncoding RNAs in cell-fate programming and reprogramming

In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of regulators of gene expression. lncRNAs exhibit several distinctive features that confer unique regulatory functions, including exquisite cell- and tissue-specific expression and the capacity to transduce higher-orde...

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Bibliographic Details
Published in:Cell stem cell Vol. 14; no. 6; p. 752
Main Authors: Flynn, Ryan A, Chang, Howard Y
Format: Journal Article
Language:English
Published: United States 05.06.2014
Subjects:
Animals
Cell Differentiation - genetics
Cellular Reprogramming - genetics
Humans
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Stem Cells - cytology
Stem Cells - metabolism
ISSN:1875-9777, 1875-9777
Online Access:Get more information
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Summary:In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of regulators of gene expression. lncRNAs exhibit several distinctive features that confer unique regulatory functions, including exquisite cell- and tissue-specific expression and the capacity to transduce higher-order spatial information. Here we review evidence showing that lncRNAs exert critical functions in adult tissue stem cells, including skin, brain, and muscle, as well as in developmental patterning and pluripotency. We highlight new approaches for ascribing lncRNA functions and discuss mammalian dosage compensation as a classic example of an lncRNA network coupled to stem cell differentiation.
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ISSN:1875-9777
1875-9777
DOI:10.1016/j.stem.2014.05.014