Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

The process of pyroptosis is mediated by inflammasomes and a downstream effector known as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N-terminal domain of GSDMD forms membrane pores that promote cytolysis. Numerous proteins promote GSDMD cleavage, but none are known t...

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Bibliographic Details
Published in:	Cell Vol. 184; no. 17; p. 4495
Main Authors:	Evavold, Charles L, Hafner-Bratkovič, Iva, Devant, Pascal, D'Andrea, Jasmin M, Ngwa, Elsy M, Boršić, Elvira, Doench, John G, LaFleur, Martin W, Sharpe, Arlene H, Thiagarajah, Jay R, Kagan, Jonathan C
Format:	Journal Article
Language:	English
Published:	United States 19.08.2021
Subjects:	Adaptor Proteins, Signal Transducing - metabolism Amino Acids - metabolism Animals Cell Adhesion Molecules, Neuronal - metabolism Cell Line Genetic Testing Humans Inflammasomes - metabolism Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - metabolism Macrophages - metabolism Mechanistic Target of Rapamycin Complex 1 - metabolism Mechanistic Target of Rapamycin Complex 2 - metabolism Mice, Inbred C57BL Mitochondria - metabolism Monomeric GTP-Binding Proteins - metabolism Nerve Growth Factors - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Phosphate-Binding Proteins - chemistry Phosphate-Binding Proteins - metabolism Protein Domains Protein Multimerization Pyroptosis Reactive Oxygen Species - metabolism RNA, Guide, CRISPR-Cas Systems Signal Transduction TOR Serine-Threonine Kinases - metabolism pyroptosis ragulator macrophages gasdermin D innate immunity inflammasomes inflammation reactive oxygen species mtorc1
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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