Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics

[Display omitted] •RAS mutations have been non-uniformly characterized biophysically and biochemically.•We assembled the broadest-to-date resource for KRAS mutation-specific activities.•Genomics tools do not correlate with KRAS experimental data, while 3D calculations do.•Calculations indicate local...

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Bibliographic Details
Published in:	Computational and structural biotechnology journal Vol. 20; pp. 117 - 127
Main Authors:	Tripathi, Swarnendu, Dsouza, Nikita R., Mathison, Angela J., Leverence, Elise, Urrutia, Raul, Zimmermann, Michael T.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.01.2022 Research Network of Computational and Structural Biotechnology Elsevier
Subjects:	bioinformatics biotechnology data collection Data interpretation enzyme activity family Functional genomics genetic variation Genomics hydrolysis Protein science RAS mutation Structural bioinformatics Structural bioinformatics Protein science RAS mutation Genomics Functional genomics Data interpretation
ISSN:	2001-0370, 2001-0370
Online Access:	Get full text
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