Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium

Immune cells and epithelium form sophisticated barrier systems in symbiotic relationships with microbiota. Evidence suggests that immune cells can sense microbes through intact barriers, but regulation of microbial commensalism remain largely unexplored. Here, we uncovered spatial compartmentalizati...

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Veröffentlicht in:Cell Jg. 176; H. 5; S. 982
Hauptverfasser: Kobayashi, Tetsuro, Voisin, Benjamin, Kim, Do Young, Kennedy, Elizabeth A, Jo, Jay-Hyun, Shih, Han-Yu, Truong, Amanda, Doebel, Thomas, Sakamoto, Keiko, Cui, Chang-Yi, Schlessinger, David, Moro, Kazuyo, Nakae, Susumu, Horiuchi, Keisuke, Zhu, Jinfang, Leonard, Warren J, Kong, Heidi H, Nagao, Keisuke
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 21.02.2019
Schlagworte:
Animals
Bacteria - metabolism
Cytokines - metabolism
Epithelium - immunology
Hair Follicle - metabolism
Hair Follicle - microbiology
Immunity, Innate
Interleukin-7 - metabolism
Lymphocytes - immunology
Lymphocytes - metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Microbiota - immunology
Receptors, CCR6 - metabolism
Receptors, Notch - metabolism
Receptors, Tumor Necrosis Factor - metabolism
Sebaceous Glands - immunology
Sebaceous Glands - metabolism
Sebaceous Glands - microbiology
Skin - metabolism
Skin Physiological Phenomena
Symbiosis
Thymic Stromal Lymphopoietin
ISSN:1097-4172, 1097-4172
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Zusammenfassung:Immune cells and epithelium form sophisticated barrier systems in symbiotic relationships with microbiota. Evidence suggests that immune cells can sense microbes through intact barriers, but regulation of microbial commensalism remain largely unexplored. Here, we uncovered spatial compartmentalization of skin-resident innate lymphoid cells (ILCs) and modulation of sebaceous glands by a subset of RORγt ILCs residing within hair follicles in close proximity to sebaceous glands. Their persistence in skin required IL-7 and thymic stromal lymphopoietin, and localization was dependent on the chemokine receptor CCR6. ILC subsets expressed TNF receptor ligands, which limited sebocyte growth by repressing Notch signaling pathway. Consequently, loss of ILCs resulted in sebaceous hyperplasia with increased production of antimicrobial lipids and restricted commensalism of Gram-positive bacterial communities. Thus, epithelia-derived signals maintain skin-resident ILCs that regulate microbial commensalism through sebaceous gland-mediated tuning of the barrier surface, highlighting an immune-epithelia circuitry that facilitates host-microbe symbiosis.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2018.12.031