Uric Acid Level and New-Onset Atrial Fibrillation in the Japanese General Population　- Longitudinal Study

The independent role of uric acid (UA) as a risk factor for atrial fibrillation (AF) has not been fully elucidated. We studied 111,566 subjects (53,416 men; 58,150 women) who underwent annual health check-ups. We divided them by sex into tertile of baseline UA. To investigate the predictive power of...

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Published in:Circulation journal : official journal of the Japanese Circulation Society Vol. 83; no. 1; p. 156
Main Authors: Kawasoe, Shin, Kubozono, Takuro, Yoshifuku, Shiro, Ojima, Satoko, Miyata, Masaaki, Miyahara, Hironori, Maenohara, Shigeho, Ohishi, Mitsuru
Format: Journal Article
Language:English
Published: Japan 25.12.2018
Subjects:
Adult
Age Factors
Aged
Asian People
Atrial Fibrillation - blood
Atrial Fibrillation - epidemiology
Atrial Fibrillation - physiopathology
Female
Humans
Japan - epidemiology
Longitudinal Studies
Male
Middle Aged
Risk Factors
Sex Factors
Uric Acid - blood
Japan
Body mass index
Blood pressure
Uric acid
Sex difference
Atrial fibrillation
ISSN:1347-4820, 1347-4820
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Summary:The independent role of uric acid (UA) as a risk factor for atrial fibrillation (AF) has not been fully elucidated. We studied 111,566 subjects (53,416 men; 58,150 women) who underwent annual health check-ups. We divided them by sex into tertile of baseline UA. To investigate the predictive power of UA for new-onset AF, we performed Cox proportional hazard analysis including UA tertiles, body mass index, creatinine, smoking and drinking status, and presence of hypertension, diabetes, and dyslipidemia. During 4.1 years, 467 men (0.87%) and 180 women (0.31%) had AF (P<0.001). Cut-off points for tertiles of UA were as follows: women, ≤3.9, 4.0-4.8, and ≥4.9 mg/dL; men, ≤5.4, 5.5-6.4, and ≥6.5 mg/dL. Hazard ratio (HR) for third to first tertile was 1.74 (95% CI: 1.15-2.70; P=0.008), whereas there were no differences between tertiles in men. Rate of new-onset AF was significantly higher in the group with initially increased UA (ΔUA ≥0.3 mg/dL) than that with unchanged UA (ΔUA, -0.2 or +0.2 mg/dL) in the third tertile of baseline UA in both sexes. Higher baseline UA was significantly associated with higher AF incidence in women. Initial increase in UA was significantly associated with AF incidence when baseline UA was ≥6.5 mg/dL in men, and ≥4.9 mg/dL in women.
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ISSN:1347-4820
1347-4820
DOI:10.1253/circj.CJ-18-0508