Daily aciclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial

Most people infected with HIV-1 are dually infected with herpes simplex virus type 2. Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown. We investigated the effect of aciclovir on HIV-1 progression. In a trial with...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 375; no. 9717; pp. 824 - 833
Main Authors:	Lingappa, Jairam R, Baeten, Jared M, Wald, Anna, Hughes, James P, Thomas, Katherine K, Mujugira, Andrew, Mugo, Nelly, Bukusi, Elizabeth A, Cohen, Craig R, Katabira, Elly, Ronald, Allan, Kiarie, James, Farquhar, Carey, Stewart, Grace John, Makhema, Joseph, Essex, Myron, Were, Edwin, Fife, Kenneth H, de Bruyn, Guy, Gray, Glenda E, McIntyre, James A, Manongi, Rachel, Kapiga, Saidi, Coetzee, David, Allen, Susan, Inambao, Mubiana, Kayitenkore, Kayitesi, Karita, Etienne, Kanweka, William, Delany, Sinead, Rees, Helen, Vwalika, Bellington, Magaret, Amalia S, Wang, Richard S, Kidoguchi, Lara, Barnes, Linda, Ridzon, Renee, Corey, Lawrence, Celum, Connie
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 06.03.2010 Elsevier Elsevier Limited
Subjects:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral agents Antiviral agents Biological and medical sciences Disease transmission General aspects Herpes viruses Herpesvirus HIV Human immunodeficiency virus Human subjects Human viral diseases Infectious diseases Internal Medicine Medical sciences Mortality Pharmacology. Drug treatments Plasma Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Africa Acyclic nucleoside Purine nucleoside Prognosis HIV-1 virus Alphaherpesvirinae Daily Aciclovir Human herpesvirus 2 Nucleoside analog Antiviral Clinical trial Evolution DNA polymerase inhibitor Immunopathology Herpesviridae Retroviridae AIDS Immune deficiency Lentivirus Randomized controlled trial Infection Virus Medicine Viral disease Placebo Human immunodeficiency virus
ISSN:	0140-6736, 1474-547X
Online Access:	Get full text
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