Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities

Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid progeny. We show here that maladaptive BM-mediated TII underlies inflammatory comorbidities, as exemplified by the periodontitis-...

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Bibliographic Details
Published in:	Cell Vol. 185; no. 10; p. 1709
Main Authors:	Li, Xiaofei, Wang, Hui, Yu, Xiang, Saha, Gundappa, Kalafati, Lydia, Ioannidis, Charalampos, Mitroulis, Ioannis, Netea, Mihai G, Chavakis, Triantafyllos, Hajishengallis, George
Format:	Journal Article
Language:	English
Published:	United States 12.05.2022
Subjects:	Animals Arthritis Hematopoietic Stem Cells Immunity, Innate Mice Myelopoiesis Periodontitis arthritis comorbidities inflammation myelopoiesis periodontitis hematopoietic stem and progenitor cells epigenetic rewiring trained immunity bone marrow transplantation
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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