Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood

Severe obesity is a rapidly growing global health threat. Although often attributed to unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and highly polygenic; the majority of inherited susceptibility is related to the cumulative effect of many common DNA variants...

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Vydáno v:	Cell Ročník 177; číslo 3; s. 587
Hlavní autoři:	Khera, Amit V, Chaffin, Mark, Wade, Kaitlin H, Zahid, Sohail, Brancale, Joseph, Xia, Rui, Distefano, Marina, Senol-Cosar, Ozlem, Haas, Mary E, Bick, Alexander, Aragam, Krishna G, Lander, Eric S, Smith, George Davey, Mason-Suares, Heather, Fornage, Myriam, Lebo, Matthew, Timpson, Nicholas J, Kaplan, Lee M, Kathiresan, Sekar
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 18.04.2019
Témata:	Adolescent Body Mass Index Body Weight Child Databases, Factual Female Genome-Wide Association Study Humans Infant, Newborn Longitudinal Studies Male Middle Aged Multifactorial Inheritance - genetics Obesity - genetics Obesity - pathology Risk Factors Severity of Illness Index melanocortin 4 receptor genomic medicine human genetics body mass index weight severe obesity UK Biobank genetic risk prediction polygenic score
ISSN:	1097-4172, 1097-4172
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