Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in cancer through the viral defense pathway. In ovarian cancer (OC), DNMTis trigger cytosolic sensing of double-stranded RNA (dsRNA) causing a type I interferon response and apoptosis. Knocking down dsRNA sensors TLR3...

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Bibliographic Details
Published in:	Cell Vol. 162; no. 5; p. 974
Main Authors:	Chiappinelli, Katherine B, Strissel, Pamela L, Desrichard, Alexis, Li, Huili, Henke, Christine, Akman, Benjamin, Hein, Alexander, Rote, Neal S, Cope, Leslie M, Snyder, Alexandra, Makarov, Vladimir, Budhu, Sadna, Buhu, Sadna, Slamon, Dennis J, Wolchok, Jedd D, Pardoll, Drew M, Beckmann, Matthias W, Zahnow, Cynthia A, Merghoub, Taha, Mergoub, Taha, Chan, Timothy A, Baylin, Stephen B, Strick, Reiner
Format:	Journal Article
Language:	English
Published:	United States 27.08.2015
Subjects:	Animals Azacitidine - pharmacology Cell Line, Tumor DNA Methylation - drug effects DNA Modification Methylases - antagonists & inhibitors Endogenous Retroviruses - genetics Female Humans Immunotherapy Interferon Type I - immunology Lung Neoplasms - drug therapy Lung Neoplasms - immunology Melanoma - immunology Melanoma - therapy Mice Mice, Inbred C57BL Ovarian Neoplasms - immunology Ovarian Neoplasms - therapy RNA, Double-Stranded - metabolism
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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