Functional Enhancers Shape Extrachromosomal Oncogene Amplifications

Non-coding regions amplified beyond oncogene borders have largely been ignored. Using a computational approach, we find signatures of significant co-amplification of non-coding DNA beyond the boundaries of amplified oncogenes across five cancer types. In glioblastoma, EGFR is preferentially co-ampli...

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Veröffentlicht in:	Cell Jg. 179; H. 6; S. 1330
Hauptverfasser:	Morton, Andrew R, Dogan-Artun, Nergiz, Faber, Zachary J, MacLeod, Graham, Bartels, Cynthia F, Piazza, Megan S, Allan, Kevin C, Mack, Stephen C, Wang, Xiuxing, Gimple, Ryan C, Wu, Qiulian, Rubin, Brian P, Shetty, Shashirekha, Angers, Stephane, Dirks, Peter B, Sallari, Richard C, Lupien, Mathieu, Rich, Jeremy N, Scacheri, Peter C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 27.11.2019
Schlagworte:	Acetylation Cell Line, Tumor Cell Survival - genetics Chromatin - metabolism Chromosomes, Human - genetics CRISPR-Cas Systems - genetics DNA, Neoplasm - genetics Enhancer Elements, Genetic ErbB Receptors - genetics ErbB Receptors - metabolism Gene Amplification Genes, Neoplasm Genetic Loci Glioblastoma - genetics Glioblastoma - pathology Histones - metabolism Humans Neuroglia - metabolism Oncogenes enhancer MYCN double minute glioblastoma epigenetic MYC oncogene amplification extrachromosomal DNA EGFR
ISSN:	1097-4172, 1097-4172
Online-Zugang:	Weitere Angaben
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