Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

Although mutations in DNA are the best-studied source of neoantigens that determine response to immune checkpoint blockade, alterations in RNA splicing within cancer cells could similarly result in neoepitope production. However, the endogenous antigenicity and clinical potential of such splicing-de...

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Bibliographic Details
Published in:	Cell Vol. 184; no. 15; p. 4032
Main Authors:	Lu, Sydney X, De Neef, Emma, Thomas, James D, Sabio, Erich, Rousseau, Benoit, Gigoux, Mathieu, Knorr, David A, Greenbaum, Benjamin, Elhanati, Yuval, Hogg, Simon J, Chow, Andrew, Ghosh, Arnab, Xie, Abigail, Zamarin, Dmitriy, Cui, Daniel, Erickson, Caroline, Singer, Michael, Cho, Hana, Wang, Eric, Lu, Bin, Durham, Benjamin H, Shah, Harshal, Chowell, Diego, Gabel, Austin M, Shen, Yudao, Liu, Jing, Jin, Jian, Rhodes, Matthew C, Taylor, Richard E, Molina, Henrik, Wolchok, Jedd D, Merghoub, Taha, Diaz, Jr, Luis A, Abdel-Wahab, Omar, Bradley, Robert K
Format:	Journal Article
Language:	English
Published:	United States 22.07.2021
Subjects:	Animals Antigen Presentation - drug effects Antigen Presentation - immunology Antigens, Neoplasm - metabolism Cell Line, Tumor Cell Proliferation - drug effects Epitopes - immunology Ethylenediamines - pharmacology Gene Expression Regulation, Neoplastic - drug effects Hematopoiesis - drug effects Hematopoiesis - genetics Histocompatibility Antigens Class I - metabolism Humans Immune Checkpoint Inhibitors - pharmacology Immunotherapy Inflammation - pathology Mice Mice, Inbred C57BL Neoplasms - genetics Neoplasms - immunology Peptides - metabolism Protein Isoforms - metabolism Pyrroles - pharmacology RNA Splicing - drug effects RNA Splicing - genetics Sulfonamides - pharmacology T-Lymphocytes - drug effects T-Lymphocytes - immunology RBM39 neoepitopes PRMTs immunotherapy immunopeptidome neoantigens splicing PD1 RNA splicing immune checkpoint blockade
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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