The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis

The Ets family transcription factor PU.1 is crucial for the regulation of hematopoietic development. Pu.1 is activated in hematopoietic stem cells and is expressed in mast cells, B cells, granulocytes, and macrophages but is switched off in T cells. Many of the transcription factors regulating Pu.1...

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Bibliographic Details
Published in:	Molecular and cellular biology Vol. 27; no. 21; p. 7425
Main Authors:	Hoogenkamp, Maarten, Krysinska, Hanna, Ingram, Richard, Huang, Gang, Barlow, Rachael, Clarke, Deborah, Ebralidze, Alexander, Zhang, Pu, Tagoh, Hiromi, Cockerill, Peter N, Tenen, Daniel G, Bonifer, Constanze
Format:	Journal Article
Language:	English
Published:	United States 01.11.2007
Subjects:	Animals B-Lymphocytes - enzymology B-Lymphocytes - metabolism Base Sequence Cell Differentiation Cells, Cultured Chromatin - chemistry Core Binding Factor Alpha 2 Subunit - metabolism Gene Expression Regulation, Developmental Hematopoiesis - genetics Macrophages - enzymology Macrophages - metabolism Mice Molecular Sequence Data Myeloid Cells - cytology Myeloid Cells - metabolism Nucleic Acid Conformation Promoter Regions, Genetic - genetics Protein Binding Proto-Oncogene Proteins - genetics RNA Polymerase II - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Untranslated - genetics T-Lymphocytes - enzymology T-Lymphocytes - metabolism Trans-Activators - genetics Transcription Factors - metabolism Transcription, Genetic
ISSN:	0270-7306
Online Access:	Get more information
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