S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood
RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always improve oxygen delivery and is associated with ischemic events. We hypothesized that storage of blood would result in loss of NO bioactivity, impairing RBC vasodilation and thus compromising blood flow, and that...
Saved in:
| Published in: | Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 43; p. 17058 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
23.10.2007
|
| Subjects: | |
| ISSN: | 0027-8424 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always improve oxygen delivery and is associated with ischemic events. We hypothesized that storage of blood would result in loss of NO bioactivity, impairing RBC vasodilation and thus compromising blood flow, and that repleting NO bioactivity would restore RBC function. We report that S-nitrosohemoglobin (SNO-Hb) concentrations declined rapidly after storage of fresh venous blood and that hypoxic vasodilation by banked RBCs correlated strongly with the amounts of SNO-Hb (r(2) = 0.90; P < 0.0005). Renitrosylation of banked blood during storage increased the SNO-Hb content and restored its vasodilatory activity. In addition, canine coronary blood flow was greater during infusion of renitrosylated RBCs than during infusion of S-nitrosothiol-depleted RBCs, and this difference in coronary flow was accentuated by hypoxemia (P < 0.001). Our findings indicate that NO bioactivity is depleted in banked blood, impairing the vasodilatory response to hypoxia, and they suggest that SNO-Hb repletion may improve transfusion efficacy. |
|---|---|
| AbstractList | RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always improve oxygen delivery and is associated with ischemic events. We hypothesized that storage of blood would result in loss of NO bioactivity, impairing RBC vasodilation and thus compromising blood flow, and that repleting NO bioactivity would restore RBC function. We report that S-nitrosohemoglobin (SNO-Hb) concentrations declined rapidly after storage of fresh venous blood and that hypoxic vasodilation by banked RBCs correlated strongly with the amounts of SNO-Hb (r(2) = 0.90; P < 0.0005). Renitrosylation of banked blood during storage increased the SNO-Hb content and restored its vasodilatory activity. In addition, canine coronary blood flow was greater during infusion of renitrosylated RBCs than during infusion of S-nitrosothiol-depleted RBCs, and this difference in coronary flow was accentuated by hypoxemia (P < 0.001). Our findings indicate that NO bioactivity is depleted in banked blood, impairing the vasodilatory response to hypoxia, and they suggest that SNO-Hb repletion may improve transfusion efficacy. RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always improve oxygen delivery and is associated with ischemic events. We hypothesized that storage of blood would result in loss of NO bioactivity, impairing RBC vasodilation and thus compromising blood flow, and that repleting NO bioactivity would restore RBC function. We report that S-nitrosohemoglobin (SNO-Hb) concentrations declined rapidly after storage of fresh venous blood and that hypoxic vasodilation by banked RBCs correlated strongly with the amounts of SNO-Hb (r(2) = 0.90; P < 0.0005). Renitrosylation of banked blood during storage increased the SNO-Hb content and restored its vasodilatory activity. In addition, canine coronary blood flow was greater during infusion of renitrosylated RBCs than during infusion of S-nitrosothiol-depleted RBCs, and this difference in coronary flow was accentuated by hypoxemia (P < 0.001). Our findings indicate that NO bioactivity is depleted in banked blood, impairing the vasodilatory response to hypoxia, and they suggest that SNO-Hb repletion may improve transfusion efficacy.RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always improve oxygen delivery and is associated with ischemic events. We hypothesized that storage of blood would result in loss of NO bioactivity, impairing RBC vasodilation and thus compromising blood flow, and that repleting NO bioactivity would restore RBC function. We report that S-nitrosohemoglobin (SNO-Hb) concentrations declined rapidly after storage of fresh venous blood and that hypoxic vasodilation by banked RBCs correlated strongly with the amounts of SNO-Hb (r(2) = 0.90; P < 0.0005). Renitrosylation of banked blood during storage increased the SNO-Hb content and restored its vasodilatory activity. In addition, canine coronary blood flow was greater during infusion of renitrosylated RBCs than during infusion of S-nitrosothiol-depleted RBCs, and this difference in coronary flow was accentuated by hypoxemia (P < 0.001). Our findings indicate that NO bioactivity is depleted in banked blood, impairing the vasodilatory response to hypoxia, and they suggest that SNO-Hb repletion may improve transfusion efficacy. |
| Author | Reynolds, James D Angelo, Michael Ahearn, Gregory S Stamler, Jonathan S Zhang, Jian Cobb, Fred |
| Author_xml | – sequence: 1 givenname: James D surname: Reynolds fullname: Reynolds, James D organization: Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA – sequence: 2 givenname: Gregory S surname: Ahearn fullname: Ahearn, Gregory S – sequence: 3 givenname: Michael surname: Angelo fullname: Angelo, Michael – sequence: 4 givenname: Jian surname: Zhang fullname: Zhang, Jian – sequence: 5 givenname: Fred surname: Cobb fullname: Cobb, Fred – sequence: 6 givenname: Jonathan S surname: Stamler fullname: Stamler, Jonathan S |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17940022$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kDtPwzAUhT0U0QfMbMgTW4qT2LHDhioKSJUYgJXIj-vW4NghTpHy74lEmc7wnYd0lmgWYgCErnKyzgkvb7sg05pwwmsmckJnaEFIwTNBCzpHy5Q-CSETIudonvOaTrBYoI_XLLihjykeoI17H5UL2IB12kHQ4x2WuAV9kMGlFtvYYx9TwtHi7jAmF33cOy09lnpwP24Y8ZRWMnyBwcrHaC7QmZU-weVJV-h9-_C2ecp2L4_Pm_tdphmjQ1bmlJnSVlDpmltFVc4rW7PS1GAUqSQwqzjTxChRMyW14NxoKbhiVJiysMUK3fz1dn38PkIamtYlDd7LAPGYmkrQchopJuP1yXhULZim610r-7H5f6T4BZanZRw |
| CitedBy_id | crossref_primary_10_1164_rccm_201107_1332OC crossref_primary_10_1172_JCI62854 crossref_primary_10_1186_s12957_022_02705_z crossref_primary_10_1111_trf_12111 crossref_primary_10_1159_000489321 crossref_primary_10_1177_1358863X10388346 crossref_primary_10_1096_fj_10_159483 crossref_primary_10_1097_MOH_0b013e328311f422 crossref_primary_10_1111_j_1537_2995_2009_02385_x crossref_primary_10_1111_j_1537_2995_2012_03850_x crossref_primary_10_1016_j_jcin_2008_09_011 crossref_primary_10_1097_TA_0b013e3181af6a8c crossref_primary_10_1186_cc12600 crossref_primary_10_1016_j_ccc_2019_12_008 crossref_primary_10_1007_s00109_012_0878_z crossref_primary_10_1016_j_resuscitation_2015_08_015 crossref_primary_10_1111_j_1423_0410_2010_01441_x crossref_primary_10_1007_s00246_011_9901_3 crossref_primary_10_3389_fphys_2018_00041 crossref_primary_10_1111_j_1752_8062_2009_00154_x crossref_primary_10_1111_j_1537_2995_2010_02980_x crossref_primary_10_1016_j_abb_2010_09_027 crossref_primary_10_1213_ane_0b013e3181930a6e crossref_primary_10_1111_j_1537_2995_2009_02265_x crossref_primary_10_1016_j_clp_2012_06_011 crossref_primary_10_1073_pnas_0708940105 crossref_primary_10_1016_j_amjcard_2008_03_027 crossref_primary_10_1186_s40001_025_02857_0 crossref_primary_10_1016_j_mam_2021_101056 crossref_primary_10_1097_ACO_0b013e328323f7c4 crossref_primary_10_1016_j_molmed_2008_05_002 crossref_primary_10_1073_pnas_1307058110 crossref_primary_10_1111_j_1365_3148_2008_00892_x crossref_primary_10_1016_j_jcin_2008_10_008 crossref_primary_10_1111_vec_12252 crossref_primary_10_1016_j_ccc_2012_11_005 crossref_primary_10_1111_j_1600_0609_2008_01172_x crossref_primary_10_1073_pnas_0708871105 crossref_primary_10_1016_j_molmed_2009_06_007 crossref_primary_10_1097_MOP_0000000000000225 crossref_primary_10_1073_pnas_0901043106 crossref_primary_10_1097_SLA_0b013e3182822c52 crossref_primary_10_1111_j_1537_2995_2008_01807_x crossref_primary_10_1160_TH16_05_0373 crossref_primary_10_1016_j_earlhumdev_2014_02_003 crossref_primary_10_1016_j_siny_2025_101615 crossref_primary_10_1038_pr_2013_153 crossref_primary_10_1111_vox_13768 crossref_primary_10_1016_j_jpeds_2010_10_030 crossref_primary_10_1007_s12288_025_02026_7 crossref_primary_10_1038_scibx_2013_673 crossref_primary_10_1371_journal_pone_0122655 crossref_primary_10_1186_s13054_014_0690_y crossref_primary_10_1073_pnas_2220769120 crossref_primary_10_1542_peds_2010_3178 crossref_primary_10_2106_JBJS_23_00146 crossref_primary_10_1016_j_amjcard_2012_12_041 crossref_primary_10_1016_j_freeradbiomed_2015_04_025 crossref_primary_10_1073_pnas_0708160104 crossref_primary_10_1097_SHK_0000000000000089 crossref_primary_10_1016_j_jtcvs_2012_04_014 crossref_primary_10_1073_pnas_1502285112 crossref_primary_10_1016_S0049_3848_16_30105_0 crossref_primary_10_1007_s00246_015_1147_z crossref_primary_10_1111_j_1537_2995_2011_03473_x crossref_primary_10_1007_s00134_009_1526_0 crossref_primary_10_1089_ars_2010_3447 crossref_primary_10_1164_rccm_201110_1915CI crossref_primary_10_1089_ham_2023_0044 crossref_primary_10_1186_cc13730 crossref_primary_10_1177_00031348221136578 crossref_primary_10_1016_j_ahj_2010_02_017 crossref_primary_10_1111_trf_12660 crossref_primary_10_1016_j_ahj_2010_02_018 crossref_primary_10_1016_j_wneu_2020_03_202 crossref_primary_10_1016_j_amjmed_2013_09_017 crossref_primary_10_1055_s_0044_1782182 crossref_primary_10_1111_j_1540_8183_2008_00407_x crossref_primary_10_1097_PCC_0000000000001051 crossref_primary_10_1161_CIRCULATIONAHA_109_878017 crossref_primary_10_1016_j_bpj_2024_12_001 crossref_primary_10_1016_j_jacc_2008_12_073 crossref_primary_10_1073_pnas_1306489110 crossref_primary_10_1097_CCM_0000000000002217 crossref_primary_10_1111_trf_13189 crossref_primary_10_1111_cts_12530 crossref_primary_10_1517_14656566_9_11_1869 crossref_primary_10_1515_hsz_2014_0292 crossref_primary_10_1111_j_1537_2995_2007_01751_x crossref_primary_10_2217_ica_11_39 crossref_primary_10_1016_j_transci_2015_04_005 crossref_primary_10_1182_blood_2011_08_371849 crossref_primary_10_1016_j_jcrc_2016_11_004 crossref_primary_10_1111_j_1445_5994_2011_02455_x crossref_primary_10_1111_j_1537_2995_2011_03094_x crossref_primary_10_1007_s00404_013_2923_8 crossref_primary_10_1097_TA_0000000000002711 crossref_primary_10_1111_j_1537_2995_2008_01657_x crossref_primary_10_1161_CIRCRESAHA_108_176867 crossref_primary_10_1097_ACO_0b013e328312c01b crossref_primary_10_1016_j_athoracsur_2010_01_064 crossref_primary_10_1016_j_jprot_2009_11_001 crossref_primary_10_1016_j_jtcvs_2011_02_012 crossref_primary_10_1097_SHK_0000000000001386 crossref_primary_10_1038_nm1771 crossref_primary_10_1016_j_transci_2018_05_007 crossref_primary_10_1016_j_tmrv_2011_07_003 crossref_primary_10_1016_j_wneu_2017_09_038 crossref_primary_10_1002_lt_23695 crossref_primary_10_1136_heartjnl_2012_303437 crossref_primary_10_1152_japplphysiol_00995_2015 crossref_primary_10_1016_j_mehy_2013_09_020 crossref_primary_10_1097_ACO_0b013e32830f1fd1 crossref_primary_10_3109_14767058_2012_715465 crossref_primary_10_1111_trf_13609 crossref_primary_10_1042_BJ20120675 crossref_primary_10_1016_j_jcin_2009_05_004 crossref_primary_10_1016_j_athoracsur_2013_05_116 crossref_primary_10_1111_trf_15228 crossref_primary_10_3389_fphys_2024_1394650 crossref_primary_10_1182_blood_2008_07_166264 crossref_primary_10_1111_j_1778_428X_2007_00084_x crossref_primary_10_1152_japplphysiol_00657_2020 crossref_primary_10_1016_j_ahj_2009_08_001 crossref_primary_10_1159_000330483 crossref_primary_10_1038_s41598_019_49566_3 crossref_primary_10_1111_micc_12296 crossref_primary_10_1016_S1441_2772_23_01837_9 crossref_primary_10_1113_jphysiol_2012_234906 crossref_primary_10_1097_PCC_0b013e318198b139 crossref_primary_10_1038_micronano_2017_103 crossref_primary_10_1016_j_ccc_2010_01_002 crossref_primary_10_1371_journal_pone_0119991 crossref_primary_10_1016_j_ahj_2011_11_016 crossref_primary_10_1002_nadc_200856425 crossref_primary_10_1016_j_molmed_2009_08_002 crossref_primary_10_1111_j_1537_2995_2009_02173_x crossref_primary_10_3389_fphys_2019_01417 crossref_primary_10_1111_trf_12738 crossref_primary_10_1053_j_semperi_2012_04_005 crossref_primary_10_1016_j_ab_2013_06_010 crossref_primary_10_1111_j_1537_2995_2008_02002_x crossref_primary_10_1111_bjh_12095 crossref_primary_10_1007_s00345_024_05372_9 crossref_primary_10_1016_j_thromres_2011_07_047 crossref_primary_10_1016_j_jcin_2014_09_026 crossref_primary_10_3233_NPM_15814113 crossref_primary_10_1007_s10877_022_00877_3 crossref_primary_10_1111_j_1537_2995_2011_03081_x crossref_primary_10_1213_ANE_0b013e31828843e6 crossref_primary_10_1213_ane_0b013e318184cfe9 crossref_primary_10_1053_j_sempedsurg_2017_11_009 crossref_primary_10_1016_j_jacc_2009_09_076 crossref_primary_10_1016_j_tmrv_2008_09_005 crossref_primary_10_1186_s12887_020_02233_3 crossref_primary_10_1186_cc8953 crossref_primary_10_1007_s00277_012_1427_0 crossref_primary_10_1111_j_1537_2995_2007_01754_x crossref_primary_10_1007_s12519_022_00627_0 crossref_primary_10_3389_fmolb_2022_910795 crossref_primary_10_1515_raon_2015_0046 crossref_primary_10_1097_PCC_0b013e3181fe344b crossref_primary_10_1111_j_1537_2995_2011_03097_x crossref_primary_10_1038_s41390_020_01247_y crossref_primary_10_1097_ACO_0b013e3283103e84 crossref_primary_10_1016_j_ab_2012_04_014 crossref_primary_10_1097_CCM_0b013e31817e2ec5 crossref_primary_10_1097_MOH_0b013e32833157f4 crossref_primary_10_1186_s12887_022_03276_4 crossref_primary_10_1016_j_bpa_2013_02_001 crossref_primary_10_1097_TA_0b013e31827e1d40 crossref_primary_10_1111_j_1778_428X_2008_00119_x crossref_primary_10_1093_bja_aet405 crossref_primary_10_1016_j_bbrc_2016_04_019 crossref_primary_10_1111_j_1537_2995_2012_03656_x crossref_primary_10_1016_S1959_0318_10_70003_8 crossref_primary_10_1111_j_1525_1594_2011_01357_x crossref_primary_10_1097_CCM_0b013e318225754f crossref_primary_10_1111_trf_14435 crossref_primary_10_1016_j_jacc_2015_03_567 crossref_primary_10_1097_BCR_0b013e318295755d crossref_primary_10_3389_fped_2025_1639423 crossref_primary_10_3390_antiox11040747 crossref_primary_10_1111_j_1537_2995_2011_03098_x crossref_primary_10_1007_s00134_010_2017_z crossref_primary_10_1016_j_annfar_2013_02_025 crossref_primary_10_1016_j_clp_2011_12_005 crossref_primary_10_1016_j_jpedsurg_2016_10_049 crossref_primary_10_1161_CIRCRESAHA_119_315626 crossref_primary_10_1111_j_1751_2824_2008_00138_x crossref_primary_10_1111_trf_12244 crossref_primary_10_1002_iub_106 crossref_primary_10_1089_ars_2020_8153 crossref_primary_10_1371_journal_pone_0086420 crossref_primary_10_1097_CCM_0000000000003383 crossref_primary_10_1016_j_bbapap_2008_09_001 crossref_primary_10_1542_peds_2010_3252 crossref_primary_10_1111_trf_12919 crossref_primary_10_1016_j_jvs_2020_01_065 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1073/pnas.0707958104 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Sciences (General) |
| ExternalDocumentID | 17940022 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: P01 HL042444 – fundername: NIGMS NIH HHS grantid: T32 GM007171 – fundername: NHLBI NIH HHS grantid: 5P01 HL 042444 – fundername: NIGMS NIH HHS grantid: 5T32 GM 07171 |
| GroupedDBID | --- -DZ -~X .55 0R~ 123 29P 2AX 2FS 2WC 4.4 53G 5RE 5VS 85S AACGO AAFWJ AANCE AAYJJ ABBHK ABOCM ABPLY ABPPZ ABTLG ABXSQ ABZEH ACGOD ACHIC ACIWK ACNCT ACPRK ADQXQ ADULT ADXHL AENEX AEUPB AEXZC AFFNX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS AQVQM AS~ BKOMP CGR CS3 CUY CVF D0L DCCCD DIK DU5 E3Z EBS ECM EIF EJD F5P FRP GX1 H13 HH5 HQ3 HTVGU HYE IPSME JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JST KQ8 L7B LU7 MVM N9A NPM N~3 O9- OK1 P-O PNE PQQKQ R.V RHI RNA RNS RPM RXW SA0 SJN TAE TN5 UKR W8F WH7 WHG WOQ WOW X7M XSW Y6R YBH YKV YSK ZCA ~02 ~KM 7X8 |
| ID | FETCH-LOGICAL-c554t-3145d3f6e6c97fb4b176f953d9edb06ae5fb75c0db895bac877dca87b548d32f2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 242 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000250487600060&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0027-8424 |
| IngestDate | Thu Sep 04 16:28:17 EDT 2025 Mon Jul 21 06:03:24 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 43 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c554t-3145d3f6e6c97fb4b176f953d9edb06ae5fb75c0db895bac877dca87b548d32f2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://doi.org/10.1073/pnas.0707958104 |
| PMID | 17940022 |
| PQID | 68433142 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_68433142 pubmed_primary_17940022 |
| PublicationCentury | 2000 |
| PublicationDate | 2007-10-23 |
| PublicationDateYYYYMMDD | 2007-10-23 |
| PublicationDate_xml | – month: 10 year: 2007 text: 2007-10-23 day: 23 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Proceedings of the National Academy of Sciences - PNAS |
| PublicationTitleAlternate | Proc Natl Acad Sci U S A |
| PublicationYear | 2007 |
| References | 5779258 - J Lab Clin Med. 1969 May;73(5):722-33 11214321 - Nature. 2001 Feb 1;409(6820):622-6 8637569 - Nature. 1996 Mar 21;380(6571):221-6 18048331 - Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19165-6 15660821 - Transfusion. 2005 Feb;45(2):141-8 17307993 - Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3072-8 15879309 - Circ Res. 2005 May 27;96(10):1119-26 9197264 - Science. 1997 Jun 27;276(5321):2034-7 12243637 - JAMA. 2002 Sep 25;288(12):1499-507 7120526 - J Trauma. 1982 Sep;22(9):741-6 16101690 - Vox Sang. 2005 Aug;89(2):92-6 10738039 - Transfusion. 2000 Mar;40(3):353-60 16751292 - Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1507-12 15585000 - Transfusion. 2004 Dec;44(12 Suppl):4S-14S 14963010 - Circ Res. 2004 Apr 16;94(7):976-83 5458535 - Surg Gynecol Obstet. 1970 Oct;131(4):733-41 15699345 - Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2531-6 1346070 - Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):444-8 12524454 - Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):461-6 17420301 - Physiology (Bethesda). 2007 Apr;22:97-112 17076859 - Transfusion. 2006 Nov;46(11):2014-27 17442910 - N Engl J Med. 2007 Apr 19;356(16):1667-9 17940021 - Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17063-8 10777705 - Biochem Biophys Res Commun. 2000 Apr 29;271(1):217-21 8501845 - JAMA. 1993 Jun 16;269(23):3024-9 16717191 - Proc Natl Acad Sci U S A. 2006 May 30;103(22):8366-71 16439430 - J Physiol. 2006 Apr 1;572(Pt 1):295-305 15824313 - Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5709-14 6821653 - Br J Haematol. 1983 Feb;53(2):237-40 13118742 - Lancet. 1954 Jan 16;266(6803):119-24 11208980 - J Physiol. 2001 Jan 15;530(Pt 2):331-41 5764013 - J Clin Invest. 1969 Feb;48(2):311-21 12042776 - Nat Med. 2002 Jul;8(7):711-7 14980227 - Cell. 2004 Feb 20;116(4):617-28 9919558 - Methods Enzymol. 1999;301:99-114 15150083 - Blood. 2004 Sep 1;104(5):1375-82 14665591 - Br J Sports Med. 2003 Dec;37(6):516-20 4898470 - Transfusion. 1969 Sep-Oct;9(5):229-37 10747928 - J Biol Chem. 2000 Jun 2;275(22):16738-45 16203976 - Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14801-6 15467064 - JAMA. 2004 Oct 6;292(13):1610-2 12697165 - Bioorg Chem. 2003 Feb;31(1):3-10 15709954 - Annu Rev Physiol. 2005;67:99-145 16565424 - Proc Am Thorac Soc. 2006 Apr;3(2):153-60 15467057 - JAMA. 2004 Oct 6;292(13):1555-62 9950843 - Am J Physiol. 1999 Feb;276(2 Pt 2):H438-45 11457254 - J Am Chem Soc. 2001 May 16;123(19):4615-6 14724467 - Crit Care Med. 2003 Dec;31(12 Suppl):S687-97 14707765 - Med Sci Sports Exerc. 2004 Jan;36(1):35-41 14562762 - Adv Exp Med Biol. 2003;530:645-52 3090783 - Vox Sang. 1986;51(1):27-34 17287342 - Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2157-62 10749727 - Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1294-8 3104153 - Haematologica. 1986 Nov-Dec;71(6):459-62 15504169 - Transfusion. 2004 Nov;44(11):1626-34 15811508 - J Inorg Biochem. 2005 Apr;99(4):912-21 12559009 - Transfusion. 2003 Feb;43(2):151-6 12777902 - J Trauma. 2003 May;54(5):898-905; discussion 905-7 9367862 - Biochem Biophys Res Commun. 1997 Oct 29;239(3):875-7 16545588 - Nitric Oxide. 2006 Aug;15(1):20-9 727273 - Am J Physiol. 1978 Nov;235(5):H505-15 17012349 - Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H963-70 15797251 - Arch Biochem Biophys. 2005 Apr 15;436(2):386-96 16368881 - Blood. 2006 Apr 1;107(7):2943-51 3560265 - J Trauma. 1987 Mar;27(3):243-9 |
| References_xml | – reference: 3104153 - Haematologica. 1986 Nov-Dec;71(6):459-62 – reference: 17420301 - Physiology (Bethesda). 2007 Apr;22:97-112 – reference: 8501845 - JAMA. 1993 Jun 16;269(23):3024-9 – reference: 13118742 - Lancet. 1954 Jan 16;266(6803):119-24 – reference: 14562762 - Adv Exp Med Biol. 2003;530:645-52 – reference: 9197264 - Science. 1997 Jun 27;276(5321):2034-7 – reference: 6821653 - Br J Haematol. 1983 Feb;53(2):237-40 – reference: 16751292 - Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1507-12 – reference: 7120526 - J Trauma. 1982 Sep;22(9):741-6 – reference: 11208980 - J Physiol. 2001 Jan 15;530(Pt 2):331-41 – reference: 5779258 - J Lab Clin Med. 1969 May;73(5):722-33 – reference: 727273 - Am J Physiol. 1978 Nov;235(5):H505-15 – reference: 17012349 - Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H963-70 – reference: 16368881 - Blood. 2006 Apr 1;107(7):2943-51 – reference: 10777705 - Biochem Biophys Res Commun. 2000 Apr 29;271(1):217-21 – reference: 17287342 - Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2157-62 – reference: 15879309 - Circ Res. 2005 May 27;96(10):1119-26 – reference: 15467064 - JAMA. 2004 Oct 6;292(13):1610-2 – reference: 17307993 - Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3072-8 – reference: 15797251 - Arch Biochem Biophys. 2005 Apr 15;436(2):386-96 – reference: 15585000 - Transfusion. 2004 Dec;44(12 Suppl):4S-14S – reference: 15699345 - Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2531-6 – reference: 3090783 - Vox Sang. 1986;51(1):27-34 – reference: 1346070 - Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):444-8 – reference: 14980227 - Cell. 2004 Feb 20;116(4):617-28 – reference: 17442910 - N Engl J Med. 2007 Apr 19;356(16):1667-9 – reference: 14963010 - Circ Res. 2004 Apr 16;94(7):976-83 – reference: 10749727 - Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1294-8 – reference: 12042776 - Nat Med. 2002 Jul;8(7):711-7 – reference: 18048331 - Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19165-6 – reference: 15504169 - Transfusion. 2004 Nov;44(11):1626-34 – reference: 15824313 - Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5709-14 – reference: 16717191 - Proc Natl Acad Sci U S A. 2006 May 30;103(22):8366-71 – reference: 16101690 - Vox Sang. 2005 Aug;89(2):92-6 – reference: 9950843 - Am J Physiol. 1999 Feb;276(2 Pt 2):H438-45 – reference: 12559009 - Transfusion. 2003 Feb;43(2):151-6 – reference: 15660821 - Transfusion. 2005 Feb;45(2):141-8 – reference: 9367862 - Biochem Biophys Res Commun. 1997 Oct 29;239(3):875-7 – reference: 15150083 - Blood. 2004 Sep 1;104(5):1375-82 – reference: 16203976 - Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14801-6 – reference: 11214321 - Nature. 2001 Feb 1;409(6820):622-6 – reference: 5458535 - Surg Gynecol Obstet. 1970 Oct;131(4):733-41 – reference: 17076859 - Transfusion. 2006 Nov;46(11):2014-27 – reference: 17940021 - Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17063-8 – reference: 11457254 - J Am Chem Soc. 2001 May 16;123(19):4615-6 – reference: 4898470 - Transfusion. 1969 Sep-Oct;9(5):229-37 – reference: 15811508 - J Inorg Biochem. 2005 Apr;99(4):912-21 – reference: 12524454 - Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):461-6 – reference: 14665591 - Br J Sports Med. 2003 Dec;37(6):516-20 – reference: 8637569 - Nature. 1996 Mar 21;380(6571):221-6 – reference: 10738039 - Transfusion. 2000 Mar;40(3):353-60 – reference: 9919558 - Methods Enzymol. 1999;301:99-114 – reference: 16565424 - Proc Am Thorac Soc. 2006 Apr;3(2):153-60 – reference: 16439430 - J Physiol. 2006 Apr 1;572(Pt 1):295-305 – reference: 14724467 - Crit Care Med. 2003 Dec;31(12 Suppl):S687-97 – reference: 12697165 - Bioorg Chem. 2003 Feb;31(1):3-10 – reference: 5764013 - J Clin Invest. 1969 Feb;48(2):311-21 – reference: 12243637 - JAMA. 2002 Sep 25;288(12):1499-507 – reference: 12777902 - J Trauma. 2003 May;54(5):898-905; discussion 905-7 – reference: 3560265 - J Trauma. 1987 Mar;27(3):243-9 – reference: 14707765 - Med Sci Sports Exerc. 2004 Jan;36(1):35-41 – reference: 15709954 - Annu Rev Physiol. 2005;67:99-145 – reference: 16545588 - Nitric Oxide. 2006 Aug;15(1):20-9 – reference: 15467057 - JAMA. 2004 Oct 6;292(13):1555-62 – reference: 10747928 - J Biol Chem. 2000 Jun 2;275(22):16738-45 |
| SSID | ssj0009580 |
| Score | 2.3964922 |
| Snippet | RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always improve oxygen delivery and is associated with ischemic events. We... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 17058 |
| SubjectTerms | Blood Blood Banks Cell Hypoxia Erythrocytes - cytology Erythrocytes - metabolism Hemoglobins - deficiency Humans Nitric Oxide - metabolism Nitrosation S-Nitrosothiols - metabolism Time Factors Vasodilation |
| Title | S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/17940022 https://www.proquest.com/docview/68433142 |
| Volume | 104 |
| WOSCitedRecordID | wos000250487600060&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07SwNBEF7io7BR4zM-t7DQ4jTZ94kgIoqNQVAhlWGfGDR30VN_vzubO7ARC5vrFo69mW--m935PoQOOKfCUqYyqnU3Y4GTzHggcoz5CH6BMGeT2YTs99VgkN-10FkzCwPXKhtMTEDtSgs98hOhYLaHkfPJWwaeUXC2WhtozKA5GokMxLQcqB-Su2o6gEIiDjPCGmEfSU8mha6OkzgcV73k0fYLu0xV5nrpf--3jBZrdokvpuHQRi1frKB2nb8VPqxFpo9W0dN9FpM5lsjy2Y9LkAUZFdh50JOAYcxTrPHYw1TwqBrjSGzxa6ymuAw4tUIaxMQwFgHuEziuNrp48Q6nq_Br6PH66uHyJqu9FjIbCcVHhGLGHQ3CC5vLYJjpSRFyTl3unekK7XkwktuuMyrnRlslpbNaSRP_eBwlgayj2aIs_CbC0ltuHO0ZAUIyJlfCGkeM0EF0Lc1FB-03OziMsQwHFLrw5Wc1bPawgzamH2E4mUpuDAE2gG5s_bl2Gy2k9mssL4TuoLkQs9jvonn79TGq3vdSiMRn_-72G1Q-x_E |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=S-nitrosohemoglobin+deficiency%3A+a+mechanism+for+loss+of+physiological+activity+in+banked+blood&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Reynolds%2C+James+D&rft.au=Ahearn%2C+Gregory+S&rft.au=Angelo%2C+Michael&rft.au=Zhang%2C+Jian&rft.date=2007-10-23&rft.issn=0027-8424&rft.volume=104&rft.issue=43&rft.spage=17058&rft_id=info:doi/10.1073%2Fpnas.0707958104&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0027-8424&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0027-8424&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0027-8424&client=summon |