Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome

The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces type I IFN responses to control viral replication. The cellular dsRNA binding protein PACT can also activate RIG-I. To counteract innate antiviral responses, some viruses, including Ebola virus (EBOV), encode pr...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Cell host & microbe Ročník 14; číslo 1; s. 74
Hlavní autoři:	Luthra, Priya, Ramanan, Parameshwaran, Mire, Chad E, Weisend, Carla, Tsuda, Yoshimi, Yen, Benjamin, Liu, Gai, Leung, Daisy W, Geisbert, Thomas W, Ebihara, Hideki, Amarasinghe, Gaya K, Basler, Christopher F
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 17.07.2013
Témata:	Amino Acid Motifs Cell Line DEAD Box Protein 58 DEAD-box RNA Helicases - antagonists & inhibitors DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Ebolavirus - chemistry Ebolavirus - genetics Ebolavirus - metabolism Hemorrhagic Fever, Ebola - enzymology Hemorrhagic Fever, Ebola - genetics Hemorrhagic Fever, Ebola - metabolism Hemorrhagic Fever, Ebola - virology Humans Protein Binding Receptors, Immunologic RNA, Viral - genetics RNA, Viral - metabolism RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Viral Regulatory and Accessory Proteins - antagonists & inhibitors Viral Regulatory and Accessory Proteins - chemistry Viral Regulatory and Accessory Proteins - genetics Viral Regulatory and Accessory Proteins - metabolism
ISSN:	1934-6069, 1934-6069
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!