Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation and cell death. AIM2 and NLRP3 are representative sensor proteins in two major families of inflammasomes. The adaptor protein ASC bridges the sensor proteins and caspase-1 to form ternary inflammasome comp...

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Bibliographic Details
Published in:	Cell Vol. 156; no. 6; p. 1193
Main Authors:	Lu, Alvin, Magupalli, Venkat Giri, Ruan, Jianbin, Yin, Qian, Atianand, Maninjay K, Vos, Matthijn R, Schröder, Gunnar F, Fitzgerald, Katherine A, Wu, Hao, Egelman, Edward H
Format:	Journal Article
Language:	English
Published:	United States 13.03.2014
Subjects:	Amino Acid Sequence CARD Signaling Adaptor Proteins Carrier Proteins - metabolism Cryoelectron Microscopy Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - metabolism DNA-Binding Proteins Humans Inflammasomes - chemistry Inflammasomes - metabolism Inflammasomes - ultrastructure Interleukin-1beta - metabolism Models, Molecular Molecular Sequence Data NLR Family, Pyrin Domain-Containing 3 Protein Nuclear Proteins - metabolism Polymerization Protein Structure, Tertiary
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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