Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4

Obesity promotes systemic insulin resistance through inflammatory changes that lead to the release of cytokines from activated macrophages. Although the mechanism is unclear, the second messenger cAMP has been found to attenuate macrophage activity in response to a variety of hormonal signals. We sh...

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Bibliographic Details
Published in:	Cell metabolism Vol. 19; no. 6; p. 1058
Main Authors:	Luan, Bing, Goodarzi, Mark O, Phillips, Naomi G, Guo, Xiuqing, Chen, Yii-Der I, Yao, Jie, Allison, Matthew, Rotter, Jerome I, Shaw, Reuben, Montminy, Marc
Format:	Journal Article
Language:	English
Published:	United States 03.06.2014
Subjects:	Adipose Tissue - immunology AMP-Activated Protein Kinases Animals Catecholamines - metabolism Cholera Toxin - immunology Cyclic AMP - metabolism Energy Metabolism Histone Deacetylases - biosynthesis Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Inflammation Insulin Resistance - immunology Leptin - metabolism Lipopolysaccharides - immunology Macrophages - immunology Mice Mice, Inbred C57BL Mice, Knockout Mice, Obese Obesity - immunology Obesity - metabolism Panniculitis - immunology Pertussis Toxin - immunology Phosphorylation Polymorphism, Single Nucleotide Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - genetics Signal Transduction Transcription Factor RelA - antagonists & inhibitors Transcription Factor RelA - biosynthesis Transcription Factor RelA - metabolism Viper Venoms - immunology
ISSN:	1932-7420, 1932-7420
Online Access:	Get more information
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