The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis

Non-coding regions comprise most of the human genome and harbor a significant fraction of risk alleles for neuropsychiatric diseases, yet their functions remain poorly defined. We created a high-resolution map of non-coding elements involved in human cortical neurogenesis by contrasting chromatin ac...

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Veröffentlicht in:	Cell Jg. 172; H. 1-2; S. 289
Hauptverfasser:	de la Torre-Ubieta, Luis, Stein, Jason L, Won, Hyejung, Opland, Carli K, Liang, Dan, Lu, Daning, Geschwind, Daniel H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 11.01.2018
Schlagworte:	Cell Line Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - metabolism Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly Enhancer Elements, Genetic Female Gene Expression Regulation, Developmental Humans Male Neurogenesis Neurons - cytology Neurons - metabolism Polymorphism, Genetic Receptor, Fibroblast Growth Factor, Type 2 - genetics Receptor, Fibroblast Growth Factor, Type 2 - metabolism T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism human neocortical development evolution enhancers chromatin transcription factors ATAC-seq
ISSN:	1097-4172, 1097-4172
Online-Zugang:	Weitere Angaben
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