Microstructural alterations in the locus coeruleus‐entorhinal cortex pathway in Alzheimer's disease and frontotemporal dementia
INTRODUCTION We investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (LC‐TEC) in patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD). METHODS Diffusion‐weighted MRI scans were collected for 21 AD, 20...
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| Vydáno v: | Alzheimer's & dementia : diagnosis, assessment & disease monitoring Ročník 16; číslo 1; s. e12513 - n/a |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
John Wiley and Sons Inc
01.01.2024
Wiley |
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| ISSN: | 2352-8729, 2352-8729 |
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| Abstract | INTRODUCTION
We investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (LC‐TEC) in patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD).
METHODS
Diffusion‐weighted MRI scans were collected for 21 AD, 20 behavioral variants of FTD (bvFTD), and 20 controls. Fractional anisotropy (FA), mean, axial, and radial diffusivities (MD, AxD, RD) were computed in the LC‐TEC pathway using a normative atlas. Atrophy was assessed using cortical thickness and correlated with microstructural measures.
RESULTS
We found (i) higher RD in AD than controls; (ii) higher MD, RD, and AxD, and lower FA in bvFTD than controls and AD; and (iii) a negative association between LC‐TEC MD, RD, and AxD, and entorhinal cortex (EC) thickness in bvFTD (all p < 0.050).
DISCUSSION
LC‐TEC microstructural alterations are more pronounced in bvFTD than AD, possibly reflecting neurodegeneration secondary to EC atrophy.
Highlights
Microstructural integrity of LC‐TEC pathway is understudied in AD and bvFTD.
LC‐TEC microstructural alterations are present in both AD and bvFTD.
Greater LC‐TEC microstructural alterations in bvFTD than AD.
LC‐TEC microstructural alterations in bvFTD are associated to EC neurodegeneration. |
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| AbstractList | We investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (LC-TEC) in patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD).
Diffusion-weighted MRI scans were collected for 21 AD, 20 behavioral variants of FTD (bvFTD), and 20 controls. Fractional anisotropy (FA), mean, axial, and radial diffusivities (MD, AxD, RD) were computed in the LC-TEC pathway using a normative atlas. Atrophy was assessed using cortical thickness and correlated with microstructural measures.
We found (i) higher RD in AD than controls; (ii) higher MD, RD, and AxD, and lower FA in bvFTD than controls and AD; and (iii) a negative association between LC-TEC MD, RD, and AxD, and entorhinal cortex (EC) thickness in bvFTD (all
< 0.050).
LC-TEC microstructural alterations are more pronounced in bvFTD than AD, possibly reflecting neurodegeneration secondary to EC atrophy.
Microstructural integrity of LC-TEC pathway is understudied in AD and bvFTD.LC-TEC microstructural alterations are present in both AD and bvFTD.Greater LC-TEC microstructural alterations in bvFTD than AD.LC-TEC microstructural alterations in bvFTD are associated to EC neurodegeneration. We investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (LC-TEC) in patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD).INTRODUCTIONWe investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (LC-TEC) in patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD).Diffusion-weighted MRI scans were collected for 21 AD, 20 behavioral variants of FTD (bvFTD), and 20 controls. Fractional anisotropy (FA), mean, axial, and radial diffusivities (MD, AxD, RD) were computed in the LC-TEC pathway using a normative atlas. Atrophy was assessed using cortical thickness and correlated with microstructural measures.METHODSDiffusion-weighted MRI scans were collected for 21 AD, 20 behavioral variants of FTD (bvFTD), and 20 controls. Fractional anisotropy (FA), mean, axial, and radial diffusivities (MD, AxD, RD) were computed in the LC-TEC pathway using a normative atlas. Atrophy was assessed using cortical thickness and correlated with microstructural measures.We found (i) higher RD in AD than controls; (ii) higher MD, RD, and AxD, and lower FA in bvFTD than controls and AD; and (iii) a negative association between LC-TEC MD, RD, and AxD, and entorhinal cortex (EC) thickness in bvFTD (all p < 0.050).RESULTSWe found (i) higher RD in AD than controls; (ii) higher MD, RD, and AxD, and lower FA in bvFTD than controls and AD; and (iii) a negative association between LC-TEC MD, RD, and AxD, and entorhinal cortex (EC) thickness in bvFTD (all p < 0.050).LC-TEC microstructural alterations are more pronounced in bvFTD than AD, possibly reflecting neurodegeneration secondary to EC atrophy.DISCUSSIONLC-TEC microstructural alterations are more pronounced in bvFTD than AD, possibly reflecting neurodegeneration secondary to EC atrophy.Microstructural integrity of LC-TEC pathway is understudied in AD and bvFTD.LC-TEC microstructural alterations are present in both AD and bvFTD.Greater LC-TEC microstructural alterations in bvFTD than AD.LC-TEC microstructural alterations in bvFTD are associated to EC neurodegeneration.HighlightsMicrostructural integrity of LC-TEC pathway is understudied in AD and bvFTD.LC-TEC microstructural alterations are present in both AD and bvFTD.Greater LC-TEC microstructural alterations in bvFTD than AD.LC-TEC microstructural alterations in bvFTD are associated to EC neurodegeneration. Abstract INTRODUCTION We investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (LC‐TEC) in patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD). METHODS Diffusion‐weighted MRI scans were collected for 21 AD, 20 behavioral variants of FTD (bvFTD), and 20 controls. Fractional anisotropy (FA), mean, axial, and radial diffusivities (MD, AxD, RD) were computed in the LC‐TEC pathway using a normative atlas. Atrophy was assessed using cortical thickness and correlated with microstructural measures. RESULTS We found (i) higher RD in AD than controls; (ii) higher MD, RD, and AxD, and lower FA in bvFTD than controls and AD; and (iii) a negative association between LC‐TEC MD, RD, and AxD, and entorhinal cortex (EC) thickness in bvFTD (all p < 0.050). DISCUSSION LC‐TEC microstructural alterations are more pronounced in bvFTD than AD, possibly reflecting neurodegeneration secondary to EC atrophy. Highlights Microstructural integrity of LC‐TEC pathway is understudied in AD and bvFTD. LC‐TEC microstructural alterations are present in both AD and bvFTD. Greater LC‐TEC microstructural alterations in bvFTD than AD. LC‐TEC microstructural alterations in bvFTD are associated to EC neurodegeneration. INTRODUCTION We investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (LC‐TEC) in patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD). METHODS Diffusion‐weighted MRI scans were collected for 21 AD, 20 behavioral variants of FTD (bvFTD), and 20 controls. Fractional anisotropy (FA), mean, axial, and radial diffusivities (MD, AxD, RD) were computed in the LC‐TEC pathway using a normative atlas. Atrophy was assessed using cortical thickness and correlated with microstructural measures. RESULTS We found (i) higher RD in AD than controls; (ii) higher MD, RD, and AxD, and lower FA in bvFTD than controls and AD; and (iii) a negative association between LC‐TEC MD, RD, and AxD, and entorhinal cortex (EC) thickness in bvFTD (all p < 0.050). DISCUSSION LC‐TEC microstructural alterations are more pronounced in bvFTD than AD, possibly reflecting neurodegeneration secondary to EC atrophy. Highlights Microstructural integrity of LC‐TEC pathway is understudied in AD and bvFTD. LC‐TEC microstructural alterations are present in both AD and bvFTD. Greater LC‐TEC microstructural alterations in bvFTD than AD. LC‐TEC microstructural alterations in bvFTD are associated to EC neurodegeneration. |
| Author | Pini, Lorenzo Marizzoni, Moira Quattrini, Giulia Manenti, Rosa Frisoni, Giovanni B. Boscolo Galazzo, Ilaria Jelescu, Ileana O. Pievani, Michela Jovicich, Jorge Pizzini, Francesca B. |
| AuthorAffiliation | 1 Laboratory of Alzheimer's Neuroimaging and Epidemiology (LANE) IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy 2 Department of Molecular and Translational Medicine University of Brescia Brescia Italy 5 Department of Radiology Lausanne University Hospital and University of Lausanne Lausanne Switzerland 7 Neuropsychology Unit IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy 9 Laboratory of Biological Psychiatry IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy 8 Memory Center and LANVIE ‐ Laboratory of Neuroimaging of Aging University Hospitals and University of Geneva Geneva Switzerland 3 Padova Neuroscience Center University of Padova Padova Italy 6 Center of Mind/Brain Sciences University of Trento Rovereto Italy 4 Department of Engineering for Innovation Medicine University of Verona Verona Italy |
| AuthorAffiliation_xml | – name: 2 Department of Molecular and Translational Medicine University of Brescia Brescia Italy – name: 8 Memory Center and LANVIE ‐ Laboratory of Neuroimaging of Aging University Hospitals and University of Geneva Geneva Switzerland – name: 3 Padova Neuroscience Center University of Padova Padova Italy – name: 4 Department of Engineering for Innovation Medicine University of Verona Verona Italy – name: 5 Department of Radiology Lausanne University Hospital and University of Lausanne Lausanne Switzerland – name: 9 Laboratory of Biological Psychiatry IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy – name: 6 Center of Mind/Brain Sciences University of Trento Rovereto Italy – name: 1 Laboratory of Alzheimer's Neuroimaging and Epidemiology (LANE) IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy – name: 7 Neuropsychology Unit IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy |
| Author_xml | – sequence: 1 givenname: Giulia orcidid: 0000-0002-3750-710X surname: Quattrini fullname: Quattrini, Giulia organization: University of Brescia – sequence: 2 givenname: Lorenzo surname: Pini fullname: Pini, Lorenzo organization: University of Padova – sequence: 3 givenname: Ilaria surname: Boscolo Galazzo fullname: Boscolo Galazzo, Ilaria organization: University of Verona – sequence: 4 givenname: Ileana O. surname: Jelescu fullname: Jelescu, Ileana O. organization: Lausanne University Hospital and University of Lausanne – sequence: 5 givenname: Jorge surname: Jovicich fullname: Jovicich, Jorge organization: University of Trento – sequence: 6 givenname: Rosa surname: Manenti fullname: Manenti, Rosa organization: IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli – sequence: 7 givenname: Giovanni B. surname: Frisoni fullname: Frisoni, Giovanni B. organization: University Hospitals and University of Geneva – sequence: 8 givenname: Moira surname: Marizzoni fullname: Marizzoni, Moira organization: IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli – sequence: 9 givenname: Francesca B. surname: Pizzini fullname: Pizzini, Francesca B. organization: University of Verona – sequence: 10 givenname: Michela orcidid: 0000-0002-1794-8987 surname: Pievani fullname: Pievani, Michela email: mpievani@fatebenefratelli.eu organization: IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38213948$$D View this record in MEDLINE/PubMed |
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| Keywords | behavioral variant frontotemporal dementia diffusion tensor imaging entorhinal cortex Alzheimer's disease locus coeruleus |
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| Snippet | INTRODUCTION
We investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (LC‐TEC) in... We investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (LC-TEC) in patients with... We investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (LC-TEC) in patients with... Abstract INTRODUCTION We investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex... |
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| SubjectTerms | Alzheimer's disease behavioral variant frontotemporal dementia diffusion tensor imaging entorhinal cortex locus coeruleus |
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| Title | Microstructural alterations in the locus coeruleus‐entorhinal cortex pathway in Alzheimer's disease and frontotemporal dementia |
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