Microinfarcts, brain atrophy, and cognitive function: The Honolulu Asia Aging Study Autopsy Study

Objective: This study was untaken to investigate the association of micro brain infarcts (MBIs) with antemortem global cognitive function (CF), and whether brain weight (BW) and Alzheimer lesions (neurofibrillary tangles [NFTs] or neuritic plaques [NPs]) mediate the association. Methods: Subjects we...

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Vydané v:	Annals of neurology Ročník 70; číslo 5; s. 774 - 780
Hlavní autori:	Launer, Lenore J., Hughes, Timothy M., White, Lon R.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2011 Wiley-Liss Wiley Subscription Services, Inc
Predmet:	Aged Aged, 80 and over Aging - ethnology Aging - pathology Aging - psychology Alzheimer's disease Asian Atrophy Autopsy Biological and medical sciences Brain Brain - pathology Brain Infarction - ethnology Brain Infarction - pathology Brain Infarction - psychology Cognition Cognitive ability Cohort Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Hawaii Humans Male Medical sciences Neurofibrillary Tangles - pathology Neurology Organ Size Plaque, Amyloid - ethnology Plaque, Amyloid - pathology Hawaii Atrophy Nervous system diseases Senescence Autopsy Central nervous system Encephalon
ISSN:	0364-5134, 1531-8249, 1531-8249
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Popis
Shrnutí:	Objective: This study was untaken to investigate the association of micro brain infarcts (MBIs) with antemortem global cognitive function (CF), and whether brain weight (BW) and Alzheimer lesions (neurofibrillary tangles [NFTs] or neuritic plaques [NPs]) mediate the association. Methods: Subjects were 436 well‐characterized male decedents from the Honolulu Asia Aging Autopsy Study. Brain pathology was ascertained with standardized methods, CF was measured by the Cognitive Abilities Screening Instrument, and data were analyzed using formal mediation analyses, adjusted for age at death, time between last CF measure and death, education, and head size. Based on antemortem diagnoses, demented and nondemented subjects were examined together and separately. Results: In those with no dementia, MBIs were strongly associated with the last antemortem CF score; this was significantly mediated by BW, and not NFTs or NPs. In contrast, among those with an antemortem diagnosis of dementia, NFTs had the strongest associations with BW and with CF, and MBIs were modestly associated with CF. Interpretation: This suggests that microinfarct pathology is a significant and independent factor contributing to brain atrophy and cognitive impairment, particularly before dementia is clinically evident. The role of vascular damage as initiator, stimulator, or additive contributor to neurodegeneration may differ depending on when in the trajectory toward dementia the lesions develop. ANN NEUROL 2011
Bibliografia:	ArticleID:ANA22520 NIH National Institute on Aging (NIA) - No. 1 U01 AG19349; No. 5 R01 AG017155 ark:/67375/WNG-TXFLX7JP-X NIA Intramural Research Program istex:138D7F354E7CFB8D34752964E1AA7C03B5B12EA6 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
ISSN:	0364-5134 1531-8249 1531-8249
DOI:	10.1002/ana.22520