Half a century of amyloids: past, present and future

Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued development of new therapeutics. In basic science a...

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Veröffentlicht in:	Chemical Society reviews Jg. 49; H. 15; S. 5473
Hauptverfasser:	Ke, Pu Chun, Zhou, Ruhong, Serpell, Louise C, Riek, Roland, Knowles, Tuomas P J, Lashuel, Hilal A, Gazit, Ehud, Hamley, Ian W, Davis, Thomas P, Fändrich, Marcus, Otzen, Daniel Erik, Chapman, Matthew R, Dobson, Christopher M, Eisenberg, David S, Mezzenga, Raffaele
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 07.08.2020
Schlagworte:	Alzheimer Disease - metabolism Amyloid - chemistry Amyloid - metabolism Amyloidosis Cations, Divalent - chemistry Cross-Linking Reagents - chemistry Humans Models, Molecular Molecular Conformation Printing, Three-Dimensional Protein Folding Protein Processing, Post-Translational
ISSN:	1460-4744, 1460-4744
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Abstract	Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued development of new therapeutics. In basic science and engineering, the cross-β architecture has been a constant thread underlying the structural characteristics of pathological and functional amyloids, and realizing that amyloid structures can be both pathological and functional in nature has fuelled innovations in artificial amyloids, whose use today ranges from water purification to 3D printing. At the conclusion of a half century since Eanes and Glenner's seminal study of amyloids in humans, this review commemorates the occasion by documenting the major milestones in amyloid research to date, from the perspectives of structural biology, biophysics, medicine, microbiology, engineering and nanotechnology. We also discuss new challenges and opportunities to drive this interdisciplinary field moving forward.
AbstractList	Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued development of new therapeutics. In basic science and engineering, the cross-β architecture has been a constant thread underlying the structural characteristics of pathological and functional amyloids, and realizing that amyloid structures can be both pathological and functional in nature has fuelled innovations in artificial amyloids, whose use today ranges from water purification to 3D printing. At the conclusion of a half century since Eanes and Glenner's seminal study of amyloids in humans, this review commemorates the occasion by documenting the major milestones in amyloid research to date, from the perspectives of structural biology, biophysics, medicine, microbiology, engineering and nanotechnology. We also discuss new challenges and opportunities to drive this interdisciplinary field moving forward.Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued development of new therapeutics. In basic science and engineering, the cross-β architecture has been a constant thread underlying the structural characteristics of pathological and functional amyloids, and realizing that amyloid structures can be both pathological and functional in nature has fuelled innovations in artificial amyloids, whose use today ranges from water purification to 3D printing. At the conclusion of a half century since Eanes and Glenner's seminal study of amyloids in humans, this review commemorates the occasion by documenting the major milestones in amyloid research to date, from the perspectives of structural biology, biophysics, medicine, microbiology, engineering and nanotechnology. We also discuss new challenges and opportunities to drive this interdisciplinary field moving forward. Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued development of new therapeutics. In basic science and engineering, the cross-β architecture has been a constant thread underlying the structural characteristics of pathological and functional amyloids, and realizing that amyloid structures can be both pathological and functional in nature has fuelled innovations in artificial amyloids, whose use today ranges from water purification to 3D printing. At the conclusion of a half century since Eanes and Glenner's seminal study of amyloids in humans, this review commemorates the occasion by documenting the major milestones in amyloid research to date, from the perspectives of structural biology, biophysics, medicine, microbiology, engineering and nanotechnology. We also discuss new challenges and opportunities to drive this interdisciplinary field moving forward.
Author	Knowles, Tuomas P J Riek, Roland Eisenberg, David S Otzen, Daniel Erik Zhou, Ruhong Serpell, Louise C Chapman, Matthew R Ke, Pu Chun Gazit, Ehud Davis, Thomas P Dobson, Christopher M Fändrich, Marcus Mezzenga, Raffaele Lashuel, Hilal A Hamley, Ian W
Author_xml	– sequence: 1 givenname: Pu Chun surname: Ke fullname: Ke, Pu Chun organization: Zhongshan Hospital, Fudan University, 111 Yixueyuan Rd, Xuhui District, Shanghai, China – sequence: 2 givenname: Ruhong surname: Zhou fullname: Zhou, Ruhong – sequence: 3 givenname: Louise C surname: Serpell fullname: Serpell, Louise C – sequence: 4 givenname: Roland surname: Riek fullname: Riek, Roland – sequence: 5 givenname: Tuomas P J surname: Knowles fullname: Knowles, Tuomas P J – sequence: 6 givenname: Hilal A surname: Lashuel fullname: Lashuel, Hilal A – sequence: 7 givenname: Ehud surname: Gazit fullname: Gazit, Ehud – sequence: 8 givenname: Ian W surname: Hamley fullname: Hamley, Ian W – sequence: 9 givenname: Thomas P surname: Davis fullname: Davis, Thomas P – sequence: 10 givenname: Marcus surname: Fändrich fullname: Fändrich, Marcus – sequence: 11 givenname: Daniel Erik surname: Otzen fullname: Otzen, Daniel Erik – sequence: 12 givenname: Matthew R surname: Chapman fullname: Chapman, Matthew R – sequence: 13 givenname: Christopher M surname: Dobson fullname: Dobson, Christopher M – sequence: 14 givenname: David S surname: Eisenberg fullname: Eisenberg, David S – sequence: 15 givenname: Raffaele surname: Mezzenga fullname: Mezzenga, Raffaele
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32632432$$D View this record in MEDLINE/PubMed
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Snippet	Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for...
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SubjectTerms	Alzheimer Disease - metabolism Amyloid - chemistry Amyloid - metabolism Amyloidosis Cations, Divalent - chemistry Cross-Linking Reagents - chemistry Humans Models, Molecular Molecular Conformation Printing, Three-Dimensional Protein Folding Protein Processing, Post-Translational
Title	Half a century of amyloids: past, present and future
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