Black sheep get the blues: A psychobiological model of social rejection and depression

Major life events involving social rejection are strongly associated with onset of depression. To account for this relation, we propose a psychobiological model in which rejection-related stressors elicit a distinct and integrated set of cognitive, emotional, and biological changes that may evoke de...

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Vydané v:	Neuroscience and biobehavioral reviews Ročník 35; číslo 1; s. 39 - 45
Hlavní autori:	Slavich, George M., O’Donovan, Aoife, Epel, Elissa S., Kemeny, Margaret E.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Kidlington Elsevier Ltd 01.09.2010 Elsevier
Predmet:	5- HTTLPR Adult and adolescent clinical studies Aging Animals Behavioral psychophysiology Biological and medical sciences Cortisol Depression Depression - genetics Depression - physiopathology Depression - psychology Dorsal anterior cingulate cortex Fundamental and applied biological sciences. Psychology Glucocorticoid resistance Humans Immune cell aging Inflammation Life stress Medical sciences Mood disorders Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Rejection, Psychology Social rejection Stress sensitization Stress, Psychological - physiopathology Stress, Psychological - psychology Glucocorticoid resistance Life stress Stress sensitization 5- HTTLPR Social rejection Dorsal anterior cingulate cortex Depression Cortisol Inflammation Immune cell aging Senescence Central nervous system Review Hydrocortisone Glucocorticoid Encephalon Cingulate cortex Sensitization Ungulata Mood disorder Corticosteroid 5-HTTLPR Steroid hormone Antiinflammatory agent Stress Vertebrata Mammalia Serotonin transporter Animal Adrenal hormone Sheep Models Artiodactyla
ISSN:	0149-7634, 1873-7528, 1873-7528
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