Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology

Telomeres are engaged in a host of cellular functions, and their length is regulated by multiple genes. Telomere shortening, in the course of somatic cell replication, ultimately leads to replicative senescence. In humans, rare mutations in genes that regulate telomere length have been identified in...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 20; p. 9293
Main Authors:	Levy, Daniel, Neuhausen, Susan L, Hunt, Steven C, Kimura, Masayuki, Hwang, Shih-Jen, Chen, Wei, Bis, Joshua C, Fitzpatrick, Annette L, Smith, Erin, Johnson, Andrew D, Gardner, Jeffrey P, Srinivasan, Sathanur R, Schork, Nicholas, Rotter, Jerome I, Herbig, Utz, Psaty, Bruce M, Sastrasinh, Malinee, Murray, Sarah S, Vasan, Ramachandran S, Province, Michael A, Glazer, Nicole L, Lu, Xiaobin, Cao, Xiaojian, Kronmal, Richard, Mangino, Massimo, Soranzo, Nicole, Spector, Tim D, Berenson, Gerald S, Aviv, Abraham
Format:	Journal Article
Language:	English
Published:	United States 18.05.2010
Subjects:	Cohort Studies Genome-Wide Association Study Genotype Humans Leukocytes - chemistry Leukocytes - physiology Polymorphism, Single Nucleotide - genetics Receptors, CXCR4 - genetics Receptors, CXCR4 - physiology Telomere - genetics Telomere - physiology Telomere-Binding Proteins - genetics Telomere-Binding Proteins - physiology
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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