Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology

Telomeres are engaged in a host of cellular functions, and their length is regulated by multiple genes. Telomere shortening, in the course of somatic cell replication, ultimately leads to replicative senescence. In humans, rare mutations in genes that regulate telomere length have been identified in...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 107; číslo 20; s. 9293
Hlavní autori:	Levy, Daniel, Neuhausen, Susan L, Hunt, Steven C, Kimura, Masayuki, Hwang, Shih-Jen, Chen, Wei, Bis, Joshua C, Fitzpatrick, Annette L, Smith, Erin, Johnson, Andrew D, Gardner, Jeffrey P, Srinivasan, Sathanur R, Schork, Nicholas, Rotter, Jerome I, Herbig, Utz, Psaty, Bruce M, Sastrasinh, Malinee, Murray, Sarah S, Vasan, Ramachandran S, Province, Michael A, Glazer, Nicole L, Lu, Xiaobin, Cao, Xiaojian, Kronmal, Richard, Mangino, Massimo, Soranzo, Nicole, Spector, Tim D, Berenson, Gerald S, Aviv, Abraham
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 18.05.2010
Predmet:	Cohort Studies Genome-Wide Association Study Genotype Humans Leukocytes - chemistry Leukocytes - physiology Polymorphism, Single Nucleotide - genetics Receptors, CXCR4 - genetics Receptors, CXCR4 - physiology Telomere - genetics Telomere - physiology Telomere-Binding Proteins - genetics Telomere-Binding Proteins - physiology
ISSN:	1091-6490, 1091-6490
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