SARS‐CoV‐2 targets neurons of 3D human brain organoids

COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency. COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS‐CoV‐2 on the central nervous system (CN...

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Published in:	The EMBO journal Vol. 39; no. 20; pp. e106230 - n/a
Main Authors:	Ramani, Anand, Müller, Lisa, Ostermann, Philipp N, Gabriel, Elke, Abida‐Islam, Pranty, Müller‐Schiffmann, Andreas, Mariappan, Aruljothi, Goureau, Olivier, Gruell, Henning, Walker, Andreas, Andrée, Marcel, Hauka, Sandra, Houwaart, Torsten, Dilthey, Alexander, Wohlgemuth, Kai, Omran, Heymut, Klein, Florian, Wieczorek, Dagmar, Adams, Ortwin, Timm, Jörg, Korth, Carsten, Schaal, Heiner, Gopalakrishnan, Jay
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.10.2020 Springer Nature B.V EMBO Press John Wiley and Sons Inc
Subjects:	Abnormalities Animals Axons Betacoronavirus - physiology Brain Brain - virology brain organoids Cell Death Central nervous system Chlorocebus aethiops Coronaviruses COVID-19 EMBO23 EMBO24 EMBO27 Exposure Humans Life Sciences Nervous system Nervous System Diseases - virology Neuroimaging Neurons Neurons - virology Neurotoxicity Organoids Pandemics Phosphorylation Public health SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Tau pathology Tau protein tau Proteins - metabolism Tropism Vero Cells Viral diseases Tau pathology brain organoids cell death SARS‐CoV-2 neurons SARS-CoV-2
ISSN:	0261-4189, 1460-2075, 1460-2075
Online Access:	Get full text
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Abstract	COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency. COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS‐CoV‐2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS‐CoV‐2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS‐CoV‐2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS‐CoV‐2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS‐CoV‐2 and emphasize that brain organoids could model CNS pathologies of COVID‐19. Synopsis Modelling coronavirus exposure of the central nervous system is critical to assess the cellular tropism and potential neurological consequences of infection. Here, a Düsseldorf isolate of SARS‐CoV‐2 is shown to enter human cerebral organoids and preferably target neuronal cells. Clinical SARS‐CoV-2 strain targets neurons of 3D human brain organoids. SARS‐CoV-2 does not appear to actively proliferate in neurons. SARS‐CoV-2 is associated with Tau abnormalities in neurons. SARS‐CoV-2 induces neuronal cell death. Graphical Abstract In vitro exposure of cerebral organoids to coronavirus results in preferential infection and cell death of neuronal cells.
AbstractList	COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency. COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS‐CoV‐2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS‐CoV‐2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS‐CoV‐2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS‐CoV‐2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS‐CoV‐2 and emphasize that brain organoids could model CNS pathologies of COVID‐19. Synopsis Modelling coronavirus exposure of the central nervous system is critical to assess the cellular tropism and potential neurological consequences of infection. Here, a Düsseldorf isolate of SARS‐CoV‐2 is shown to enter human cerebral organoids and preferably target neuronal cells. Clinical SARS‐CoV-2 strain targets neurons of 3D human brain organoids. SARS‐CoV-2 does not appear to actively proliferate in neurons. SARS‐CoV-2 is associated with Tau abnormalities in neurons. SARS‐CoV-2 induces neuronal cell death. Graphical Abstract In vitro exposure of cerebral organoids to coronavirus results in preferential infection and cell death of neuronal cells. COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency. COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS‐CoV‐2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS‐CoV‐2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS‐CoV‐2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS‐CoV‐2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS‐CoV‐2 and emphasize that brain organoids could model CNS pathologies of COVID‐19. Synopsis Modelling coronavirus exposure of the central nervous system is critical to assess the cellular tropism and potential neurological consequences of infection. Here, a Düsseldorf isolate of SARS‐CoV‐2 is shown to enter human cerebral organoids and preferably target neuronal cells. Clinical SARS‐CoV-2 strain targets neurons of 3D human brain organoids. SARS‐CoV-2 does not appear to actively proliferate in neurons. SARS‐CoV-2 is associated with Tau abnormalities in neurons. SARS‐CoV-2 induces neuronal cell death. In vitro exposure of cerebral organoids to coronavirus results in preferential infection and cell death of neuronal cells. COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS-CoV-2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS-CoV-2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS-CoV-2 and emphasize that brain organoids could model CNS pathologies of COVID-19. COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS-CoV-2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS-CoV-2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS-CoV-2 and emphasize that brain organoids could model CNS pathologies of COVID-19.COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS-CoV-2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS-CoV-2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS-CoV-2 and emphasize that brain organoids could model CNS pathologies of COVID-19. COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency. COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS‐CoV‐2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS‐CoV‐2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS‐CoV‐2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS‐CoV‐2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS‐CoV‐2 and emphasize that brain organoids could model CNS pathologies of COVID‐19. In vitro exposure of cerebral organoids to coronavirus results in preferential infection and cell death of neuronal cells. COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS-CoV-2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS-CoV-2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS-CoV-2 and emphasize that brain organoids could model CNS pathologies of COVID-19.
Author	Omran, Heymut Ostermann, Philipp N Korth, Carsten Gruell, Henning Gopalakrishnan, Jay Timm, Jörg Schaal, Heiner Dilthey, Alexander Mariappan, Aruljothi Müller‐Schiffmann, Andreas Wieczorek, Dagmar Andrée, Marcel Ramani, Anand Walker, Andreas Abida‐Islam, Pranty Hauka, Sandra Wohlgemuth, Kai Gabriel, Elke Houwaart, Torsten Müller, Lisa Adams, Ortwin Klein, Florian Goureau, Olivier
AuthorAffiliation	2 Institute of Virology Medical Faculty University Hospital Düsseldorf Heinrich‐Heine‐Universität Düsseldorf Germany 6 Institute of Medical Microbiology and Hygiene University Hospital Heinrich‐Heine‐University Düsseldorf Düsseldorf Germany 7 Department of General Pediatrics University Children's Hospital Muenster Muenster Germany 9 Center for Molecular Medicine Cologne (CMMC) University of Cologne Cologne Germany 4 Institut de la Vision Sorbonne Université INSERM CNRS Paris France 8 German Center for Infection Research (DZIF) partner site Bonn‐Cologne Cologne Germany 5 Institute of Virology Faculty of Medicine University Hospital Cologne University of Cologne Cologne Germany 1 Institute of Human Genetics University Hospital Düsseldorf Heinrich‐Heine‐Universität Düsseldorf Germany 3 Institute of Neuropathology University Hospital Düsseldorf Heinrich‐Heine‐Universität Düsseldorf Germany
AuthorAffiliation_xml	– name: 4 Institut de la Vision Sorbonne Université INSERM CNRS Paris France – name: 6 Institute of Medical Microbiology and Hygiene University Hospital Heinrich‐Heine‐University Düsseldorf Düsseldorf Germany – name: 9 Center for Molecular Medicine Cologne (CMMC) University of Cologne Cologne Germany – name: 3 Institute of Neuropathology University Hospital Düsseldorf Heinrich‐Heine‐Universität Düsseldorf Germany – name: 2 Institute of Virology Medical Faculty University Hospital Düsseldorf Heinrich‐Heine‐Universität Düsseldorf Germany – name: 8 German Center for Infection Research (DZIF) partner site Bonn‐Cologne Cologne Germany – name: 5 Institute of Virology Faculty of Medicine University Hospital Cologne University of Cologne Cologne Germany – name: 7 Department of General Pediatrics University Children's Hospital Muenster Muenster Germany – name: 1 Institute of Human Genetics University Hospital Düsseldorf Heinrich‐Heine‐Universität Düsseldorf Germany
Author_xml	– sequence: 1 givenname: Anand orcidid: 0000-0002-2380-8649 surname: Ramani fullname: Ramani, Anand organization: Institute of Human Genetics, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 2 givenname: Lisa orcidid: 0000-0002-0728-0012 surname: Müller fullname: Müller, Lisa organization: Institute of Virology, Medical Faculty, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 3 givenname: Philipp N surname: Ostermann fullname: Ostermann, Philipp N organization: Institute of Virology, Medical Faculty, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 4 givenname: Elke surname: Gabriel fullname: Gabriel, Elke organization: Institute of Human Genetics, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 5 givenname: Pranty surname: Abida‐Islam fullname: Abida‐Islam, Pranty organization: Institute of Human Genetics, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 6 givenname: Andreas surname: Müller‐Schiffmann fullname: Müller‐Schiffmann, Andreas organization: Institute of Neuropathology, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 7 givenname: Aruljothi orcidid: 0000-0001-5286-9806 surname: Mariappan fullname: Mariappan, Aruljothi organization: Institute of Human Genetics, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 8 givenname: Olivier surname: Goureau fullname: Goureau, Olivier organization: Institut de la Vision, Sorbonne Université, INSERM, CNRS – sequence: 9 givenname: Henning orcidid: 0000-0002-0725-7138 surname: Gruell fullname: Gruell, Henning organization: Institute of Virology, Faculty of Medicine, University Hospital Cologne, University of Cologne – sequence: 10 givenname: Andreas surname: Walker fullname: Walker, Andreas organization: Institute of Virology, Medical Faculty, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 11 givenname: Marcel surname: Andrée fullname: Andrée, Marcel organization: Institute of Virology, Medical Faculty, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 12 givenname: Sandra surname: Hauka fullname: Hauka, Sandra organization: Institute of Virology, Medical Faculty, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 13 givenname: Torsten surname: Houwaart fullname: Houwaart, Torsten organization: Institute of Medical Microbiology and Hygiene, University Hospital, Heinrich‐Heine‐University Düsseldorf – sequence: 14 givenname: Alexander surname: Dilthey fullname: Dilthey, Alexander organization: Institute of Medical Microbiology and Hygiene, University Hospital, Heinrich‐Heine‐University Düsseldorf – sequence: 15 givenname: Kai orcidid: 0000-0003-4092-0664 surname: Wohlgemuth fullname: Wohlgemuth, Kai organization: Department of General Pediatrics, University Children's Hospital Muenster – sequence: 16 givenname: Heymut orcidid: 0000-0003-0282-6765 surname: Omran fullname: Omran, Heymut organization: Department of General Pediatrics, University Children's Hospital Muenster – sequence: 17 givenname: Florian surname: Klein fullname: Klein, Florian organization: Institute of Virology, Faculty of Medicine, University Hospital Cologne, University of Cologne, German Center for Infection Research (DZIF), partner site Bonn‐Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne – sequence: 18 givenname: Dagmar surname: Wieczorek fullname: Wieczorek, Dagmar organization: Institute of Human Genetics, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 19 givenname: Ortwin surname: Adams fullname: Adams, Ortwin organization: Institute of Virology, Medical Faculty, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 20 givenname: Jörg surname: Timm fullname: Timm, Jörg organization: Institute of Virology, Medical Faculty, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 21 givenname: Carsten surname: Korth fullname: Korth, Carsten organization: Institute of Neuropathology, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 22 givenname: Heiner orcidid: 0000-0002-1636-4365 surname: Schaal fullname: Schaal, Heiner email: schaal@uni-duesseldorf.de organization: Institute of Virology, Medical Faculty, University Hospital Düsseldorf, Heinrich‐Heine‐Universität – sequence: 23 givenname: Jay orcidid: 0000-0002-0639-8705 surname: Gopalakrishnan fullname: Gopalakrishnan, Jay email: jay.gopalakrishnan@hhu.de organization: Institute of Human Genetics, University Hospital Düsseldorf, Heinrich‐Heine‐Universität
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32876341$$D View this record in MEDLINE/PubMed https://hal.science/hal-02969415$$DView record in HAL
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Cites_doi	10.1212/WNL.0000000000010116 10.1007/s12250-020-00230-5 10.1101/2020.06.25.169946 10.1101/2020.05.30.125856 10.1016/j.stem.2017.07.007 10.1038/nature22330 10.1016/j.tcb.2014.07.005 10.1038/nature02145 10.1007/s004010100423 10.1074/jbc.M110.110957 10.1128/JVI.02012-06 10.5501/wjv.v5.i2.85 10.1126/science.abc1669 10.1111/j.1471-4159.2004.02155.x 10.1016/j.stemcr.2018.07.005 10.1148/radiol.2020201187 10.1038/nrn.2015.1 10.1016/j.jns.2020.116824 10.1007/s00018-014-1815-9 10.1038/nature12517 10.1038/ncomms1255 10.1016/j.ymeth.2007.11.008 10.1016/j.celrep.2020.107738 10.1016/j.tins.2020.04.004 10.1038/35017617 10.1002/bies.201900011 10.1038/nature14658 10.1016/S2213-2600(20)30079-5 10.1093/jnen/61.6.557 10.1016/j.ceb.2017.01.001 10.1056/NEJMc2008597 10.1038/s41591-020-0912-6 10.3233/JAD-180721 10.1186/1472-6750-12-95 10.1038/21650 10.1016/j.cell.2012.02.016 10.1128/9781555819521 10.1016/j.cell.2016.04.032 10.1016/j.idcr.2020.e00771 10.3233/JAD-2007-12410 10.1016/j.cell.2020.04.004 10.1038/s41593-019-0350-2 10.1016/j.stem.2020.06.015 10.1136/bmj.m1091 10.1006/abbi.1998.0813 10.1038/nature18296 10.1056/NEJMc2011400 10.1016/j.stem.2016.12.005 10.15252/embj.201593679 10.2807/1560-7917.ES.2020.25.3.2000045 10.1126/science.1247125 10.1016/j.tins.2014.08.004 10.1021/acschemneuro.0c00122 10.1126/sciadv.aay8828 10.1016/j.cell.2020.02.052 10.1016/j.jocn.2020.04.062
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References	Hoffmann, Kleine‐Weber, Schroeder, Kruger, Herrler, Erichsen, Schiergens, Herrler, Wu, Nitsche (CR28) 2020; 181 Yang, Han, Nilsson‐Payant, Gupta, Wang, Duan, Tang, Zhu, Zhao, Jaffre (CR55) 2020; 27 Gabriel, Wason, Ramani, Gooi, Keller, Pozniakovsky, Poser, Noack, Telugu, Calegari (CR19) 2016; 35 Wang, Mandelkow (CR52) 2016; 17 Gagliardi, Ben M'Barek, Chaffiol, Slembrouck‐Brec, Conart, Nanteau, Rabesandratana, Sahel, Duebel, Orieux (CR22) 2018; 11 Corman, Landt, Kaiser, Molenkamp, Meijer, Chu, Bleicker, Brunink, Schneider, Schmidt (CR13) 2020; 25 Sengupta, Kabat, Novak, Wu, Grundke‐Iqbal, Iqbal (CR48) 1998; 357 Cairns, Rouleau, Parker, Walsh, Gehrke, Kaplan (CR6) 2020; 6 Augustinack, Sanders, Tsai, Hyman (CR2) 2002; 61 Giandomenico, Mierau, Gibbons, Wenger, Masullo, Sit, Sutcliffe, Boulanger, Tripodi, Derivery (CR24) 2019; 22 Flint, Racaniello, Rall, Skalka, Enquist (CR17) 2015 Lancaster, Renner, Martin, Wenzel, Bicknell, Hurles, Homfray, Penninger, Jackson, Knoblich (CR32) 2013; 501 Gopalakrishnan (CR25) 2019; 41 Kondo, Shahpasand, Mannix, Qiu, Moncaster, Chen, Yao, Lin, Driver, Sun (CR30) 2015; 523 De Felice, Tovar‐Moll, Moll, Munoz, Ferreira (CR16) 2020; 43 Streit, Berliner, Papanayotou, Sirulnik, Stern (CR50) 2000; 406 Cugola, Fernandes, Russo, Freitas, Dias, Guimaraes, Benazzato, Almeida, Pignatari, Romero (CR14) 2016; 534 Lamers, Beumer, van, Knoops, Puschhof, Breugem, Ravelli, Paul, Mykytyn, Duimel (CR31) 2020; 369 Lancaster, Knoblich (CR33) 2014; 345 Song, Zhang, Israelow, Lu, Weizman, Liu, Dai, Szigeti‐Buck, Yasumoto, Wang (CR49) 2020 Birey, Andersen, Makinson, Islam, Wei, Huber, Fan, Metzler, Panagiotakos, Thom (CR5) 2017; 545 Frost, Gotz, Feany (CR18) 2015; 25 Ramakrishnan (CR45) 2016; 5 Luna‐Munoz, Chavez‐Macias, Garcia‐Sierra, Mena (CR37) 2007; 12 Chen, Wu, Chen, Yan, Yang, Chen, Ma, Xu, Yu, Wang (CR8) 2020; 368 Lu, Wulf, Zhou, Davies, Lu (CR36) 1999; 399 Helms, Kremer, Merdji, Clere‐Jehl, Schenck, Kummerlen, Collange, Boulay, Fafi‐Kremer, Ohana (CR27) 2020; 382 Lei, Yang, Hu, Sun (CR34) 2020 Schlager, Straessle, Hafen (CR46) 2012; 12 Goranci‐Buzhala, Mariappan, Gabriel, Ramani, Ricci‐Vitiani, Buccarelli, D'Alessandris, Pallini, Gopalakrishnan (CR26) 2020; 31 Janesick, Wu, Blumberg (CR29) 2015; 72 Puelles, Lutgehetmann, Lindenmeyer, Sperhake, Wong, Allweiss, Chilla, Heinemann, Wanner, Liu (CR43) 2020; 383 Qian, Nguyen, Song, Hadiono, Ogden, Hammack, Yao, Hamersky, Jacob, Zhong (CR44) 2016; 165 Cohen, Guo, Hurtado, Kwong, Mills, Trojanowski, Lee (CR10) 2011; 2 Xiang, Tanaka, Patterson, Kang, Govindaiah, Roselaar, Cakir, Kim, Lombroso, Hwang (CR54) 2017; 21 CR53 Virani, Rabold, Hanson, Haag, Elrufay, Cheema, Balaan, Bhanot (CR51) 2020; 20 Cho, Johnson (CR9) 2004; 88 Conde Cardona, Quintana Pajaro, Quintero Marzola, Ramos Villegas, Moscote Salazar (CR11) 2020; 412 Monteil, Kwon, Prado, Hagelkruys, Wimmer, Stahl, Leopoldi, Garreta, Hurtado Del Pozo, Prosper (CR40) 2020; 181 Augustinack, Schneider, Mandelkow, Hyman (CR3) 2002; 103 Darzynkiewicz, Galkowski, Zhao (CR15) 2008; 44 Mesci, Macia, Saleh, Martin‐Sancho, Yin, Snethlage, Avansini, Chanda, Muotri (CR39) 2020 Zhou, Li, Liu, Chiu, Zhao, Wang, Wei, Lee, Zhang, Chu (CR58) 2020; 26 Baig, Khaleeq, Ali, Syeda (CR4) 2020; 11 Gabriel, Gopalakrishnan (CR20) 2017; 122 Sedaghat, Karimi (CR47) 2020; 76 Giandomenico, Lancaster (CR23) 2017; 44 Poyiadji, Shahin, Noujaim, Stone, Patel, Griffith (CR42) 2020; 296 Alonso, Di Clerico, Li, Corbo, Alaniz, Grundke‐Iqbal, Iqbal (CR1) 2010; 285 Li, Moore, Vasilieva, Sui, Wong, Berne, Somasundaran, Sullivan, Luzuriaga, Greenough (CR35) 2003; 426 Castellani, Perry (CR7) 2019; 67 Coolen, Lolli, Sadeghi, Rovai, Trotta, Taccone, Creteur, Henrard, Goffard, De Witte (CR12) 2020 McCray, Pewe, Wohlford‐Lenane, Hickey, Manzel, Shi, Netland, Jia, Halabi, Sigmund (CR38) 2007; 81 Yang, Yu, Xu, Shu, Xia, Liu, Wu, Zhang, Yu, Fang (CR56) 2020; 8 Nakamura, Greenwood, Binder, Bigio, Denial, Nicholson, Zhou, Lu (CR41) 2012; 149 Gabriel, Ramani, Karow, Gottardo, Natarajan, Gooi, Goranci‐Buzhala, Krut, Peters, Nikolic (CR21) 2017; 20 Zempel, Mandelkow (CR57) 2014; 37 2020; 20 2015; 72 2017; 44 2020; 369 2020; 368 1998; 357 2020; 11 2012; 12 2016; 35 2020; 6 2020b; 8 2019; 22 2020; 296 2019; 67 2000; 406 2020; 412 2020; 43 2017; 122 2004; 88 2017; 20 2011; 2 2020a; 27 2015; 523 2020; 383 2020; 382 2002b; 103 2013; 501 2020; 181 2017; 21 2010; 285 2016; 165 2020; 76 2016; 17 2012; 149 2007; 12 2016; 5 2015; 25 2002a; 61 2003; 426 2020; 31 2019; 41 2020 2014; 37 2020; 26 2020; 25 2007; 81 1999; 399 2016; 534 2008; 44 2015 2018; 11 2014; 345 2017; 545 e_1_2_9_31_1 e_1_2_9_52_1 e_1_2_9_10_1 e_1_2_9_56_1 e_1_2_9_12_1 e_1_2_9_33_1 Song E (e_1_2_9_50_1) 2020 e_1_2_9_54_1 Mesci P (e_1_2_9_40_1) 2020 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_58_1 e_1_2_9_18_1 e_1_2_9_41_1 e_1_2_9_20_1 e_1_2_9_22_1 e_1_2_9_45_1 e_1_2_9_24_1 e_1_2_9_43_1 e_1_2_9_8_1 e_1_2_9_6_1 e_1_2_9_4_1 Lei C (e_1_2_9_35_1) 2020 e_1_2_9_2_1 Gabriel E (e_1_2_9_21_1) 2017; 122 e_1_2_9_26_1 e_1_2_9_49_1 e_1_2_9_28_1 e_1_2_9_47_1 e_1_2_9_30_1 e_1_2_9_53_1 e_1_2_9_51_1 e_1_2_9_11_1 e_1_2_9_34_1 e_1_2_9_57_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_55_1 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_17_1 e_1_2_9_36_1 e_1_2_9_59_1 e_1_2_9_19_1 e_1_2_9_42_1 e_1_2_9_46_1 e_1_2_9_23_1 e_1_2_9_44_1 e_1_2_9_7_1 e_1_2_9_5_1 e_1_2_9_3_1 e_1_2_9_9_1 e_1_2_9_25_1 e_1_2_9_27_1 e_1_2_9_48_1 e_1_2_9_29_1
References_xml	– volume: 35 start-page: 803 year: 2016 end-page: 819 ident: CR19 article-title: CPAP promotes timely cilium disassembly to maintain neural progenitor pool publication-title: EMBO J – volume: 21 start-page: 383 year: 2017 end-page: 398 ident: CR54 article-title: Fusion of regionally specified hPSC‐derived organoids models human brain development and interneuron migration publication-title: Cell Stem Cell – volume: 8 start-page: 475 year: 2020 end-page: 481 ident: CR56 article-title: Clinical course and outcomes of critically ill patients with SARS‐CoV‐2 pneumonia in Wuhan, China: a single‐centered, retrospective, observational study publication-title: Lancet Respir Med – volume: 5 start-page: 85 year: 2016 end-page: 86 ident: CR45 article-title: Determination of 50% endpoint titer using a simple formula publication-title: World J Virol – volume: 61 start-page: 557 year: 2002 end-page: 564 ident: CR2 article-title: Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre‐neurofibrillary tangles and neurofibrillary tangles publication-title: J Neuropathol Exp Neurol – volume: 43 start-page: 355 year: 2020 end-page: 357 ident: CR16 article-title: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and the central nervous system publication-title: Trends Neurosci – volume: 76 start-page: 233 year: 2020 end-page: 235 ident: CR47 article-title: Guillain Barre syndrome associated with COVID‐19 infection: a case report publication-title: J Clin Neurosci – volume: 26 start-page: 1077 year: 2020 end-page: 1083 ident: CR58 article-title: Infection of bat and human intestinal organoids by SARS‐CoV‐2 publication-title: Nat Med – year: 2020 ident: CR12 article-title: Early postmortem brain MRI findings in COVID‐19 non‐survivors publication-title: Neurology doi: 10.1212/WNL.0000000000010116 – volume: 383 start-page: 590 year: 2020 end-page: 592 ident: CR43 article-title: Multiorgan and renal tropism of SARS‐CoV‐2 publication-title: N Engl J Med – volume: 103 start-page: 26 year: 2002 end-page: 35 ident: CR3 article-title: Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease publication-title: Acta Neuropathol – volume: 181 start-page: 905 year: 2020 end-page: 913.e7 ident: CR40 article-title: Inhibition of SARS‐CoV‐2 infections in engineered human tissues using clinical‐grade soluble human ACE2 publication-title: Cell – volume: 44 start-page: 36 year: 2017 end-page: 43 ident: CR23 article-title: Probing human brain evolution and development in organoids publication-title: Curr Opin Cell Biol – volume: 426 start-page: 450 year: 2003 end-page: 454 ident: CR35 article-title: Angiotensin‐converting enzyme 2 is a functional receptor for the SARS coronavirus publication-title: Nature – volume: 368 start-page: m1091 year: 2020 ident: CR8 article-title: Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study publication-title: BMJ – volume: 357 start-page: 299 year: 1998 end-page: 309 ident: CR48 article-title: Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules publication-title: Arch Biochem Biophys – volume: 22 start-page: 669 year: 2019 end-page: 679 ident: CR24 article-title: Cerebral organoids at the air‐liquid interface generate diverse nerve tracts with functional output publication-title: Nat Neurosci – volume: 12 start-page: 365 year: 2007 end-page: 375 ident: CR37 article-title: Earliest stages of tau conformational changes are related to the appearance of a sequence of specific phospho‐dependent tau epitopes in Alzheimer's disease publication-title: J Alzheimers Dis – volume: 44 start-page: 250 year: 2008 end-page: 254 ident: CR15 article-title: Analysis of apoptosis by cytometry using TUNEL assay publication-title: Methods – volume: 88 start-page: 349 year: 2004 end-page: 358 ident: CR9 article-title: Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules publication-title: J Neurochem – volume: 406 start-page: 74 year: 2000 end-page: 78 ident: CR50 article-title: Initiation of neural induction by FGF signalling before gastrulation publication-title: Nature – volume: 545 start-page: 54 year: 2017 end-page: 59 ident: CR5 article-title: Assembly of functionally integrated human forebrain spheroids publication-title: Nature – volume: 25 start-page: 2000045 year: 2020 ident: CR13 article-title: Detection of 2019 novel coronavirus (2019‐nCoV) by real‐time RT‐PCR publication-title: Euro Surveill – volume: 31 start-page: 107738 year: 2020 ident: CR26 article-title: Rapid and efficient invasion assay of glioblastoma in human brain organoids publication-title: Cell Rep – volume: 501 start-page: 373 year: 2013 end-page: 379 ident: CR32 article-title: Cerebral organoids model human brain development and microcephaly publication-title: Nature – volume: 72 start-page: 1559 year: 2015 end-page: 1576 ident: CR29 article-title: Retinoic acid signaling and neuronal differentiation publication-title: Cell Mol Life Sci – volume: 20 start-page: 397 year: 2017 end-page: 406 ident: CR21 article-title: Recent zika virus isolates induce premature differentiation of neural progenitors in human brain organoids publication-title: Cell Stem Cell – volume: 12 start-page: 95 year: 2012 ident: CR46 article-title: Use of anionic denaturing detergents to purify insoluble proteins after overexpression publication-title: BMC Biotechnol – volume: 41 start-page: e1900011 year: 2019 ident: CR25 article-title: The emergence of stem cell‐based brain organoids: trends and challenges phosphorylates publication-title: BioEssays – volume: 382 start-page: 2268 year: 2020 end-page: 2270 ident: CR27 article-title: Neurologic features in severe SARS‐CoV‐2 infection publication-title: N Engl J Med – volume: 296 start-page: E119 year: 2020 end-page: E120 ident: CR42 article-title: COVID‐19‐associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features publication-title: Radiology – volume: 81 start-page: 813 year: 2007 end-page: 821 ident: CR38 article-title: Lethal infection of K18‐hACE2 mice infected with severe acute respiratory syndrome coronavirus publication-title: J Virol – volume: 122 start-page: 55372 year: 2017 ident: CR20 article-title: Generation of iPSC‐derived human brain organoids to model early neurodevelopmental disorders publication-title: J Vis Exp – ident: CR53 – volume: 181 start-page: 271 year: 2020 end-page: 280 ident: CR28 article-title: SARS‐CoV‐2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor publication-title: Cell – volume: 17 start-page: 5 year: 2016 end-page: 21 ident: CR52 article-title: Tau in physiology and pathology publication-title: Nat Rev Neurosci – volume: 412 start-page: 116824 year: 2020 ident: CR11 article-title: Neurotropism of SARS‐CoV 2: mechanisms and manifestations publication-title: J Neurol Sci – volume: 369 start-page: 50 year: 2020 end-page: 54 ident: CR31 article-title: SARS‐CoV‐2 productively infects human gut enterocytes publication-title: Science – year: 2015 ident: CR17 publication-title: Principles of virology – volume: 345 start-page: 1247125 year: 2014 ident: CR33 article-title: Organogenesis in a dish: modeling development and disease using organoid technologies publication-title: Science – volume: 11 start-page: 665 year: 2018 end-page: 680 ident: CR22 article-title: Characterization and transplantation of CD73‐positive photoreceptors isolated from human iPSC‐derived retinal organoids publication-title: Stem Cell Reports – volume: 27 start-page: 125 year: 2020 end-page: 136 ident: CR55 article-title: A human pluripotent stem cell‐based platform to study SARS‐CoV‐2 tropism and model virus infection in human cells and organoids publication-title: Cell Stem Cell – volume: 25 start-page: 46 year: 2015 end-page: 53 ident: CR18 article-title: Connecting the dots between tau dysfunction and neurodegeneration publication-title: Trends Cell Biol – volume: 523 start-page: 431 year: 2015 end-page: 436 ident: CR30 article-title: Antibody against early driver of neurodegeneration cis P‐tau blocks brain injury and tauopathy publication-title: Nature – volume: 285 start-page: 30851 year: 2010 end-page: 30860 ident: CR1 article-title: Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration publication-title: J Biol Chem – volume: 165 start-page: 1238 year: 2016 end-page: 1254 ident: CR44 article-title: Brain‐region‐specific organoids using mini‐bioreactors for modeling ZIKV exposure publication-title: Cell – volume: 11 start-page: 995 year: 2020 end-page: 998 ident: CR4 article-title: Evidence of the COVID‐19 virus targeting the CNS: tissue distribution, host‐virus interaction, and proposed neurotropic mechanisms publication-title: ACS Chem Neurosci – volume: 37 start-page: 721 year: 2014 end-page: 32 ident: CR57 article-title: Lost after translation: missorting of Tau protein and consequences for Alzheimer disease publication-title: Trends Neurosci – volume: 2 start-page: 252 year: 2011 ident: CR10 article-title: The acetylation of tau inhibits its function and promotes pathological tau aggregation publication-title: Nat Commun – year: 2020 ident: CR34 article-title: On the calculation of TCID50 for quantitation of virus infectivity publication-title: Virol Sin doi: 10.1007/s12250-020-00230-5 – year: 2020 ident: CR49 article-title: Neuroinvasive potential of SARS‐CoV‐2 revealed in a human brain organoid model publication-title: BioRxiv doi: 10.1101/2020.06.25.169946 – volume: 6 start-page: eaay8828 year: 2020 ident: CR6 article-title: A 3D human brain‐like tissue model of herpes‐induced Alzheimer's disease publication-title: Sci Adv – volume: 67 start-page: 447 year: 2019 end-page: 467 ident: CR7 article-title: Tau biology, tauopathy, traumatic brain injury, and diagnostic challenges publication-title: J Alzheimers Dis – year: 2020 ident: CR39 article-title: Sofosbuvir protects human brain organoids against SARS‐CoV‐2 publication-title: BioRxiv doi: 10.1101/2020.05.30.125856 – volume: 20 start-page: e00771 year: 2020 ident: CR51 article-title: Guillain‐Barre Syndrome associated with SARS‐CoV‐2 infection publication-title: IDCases – volume: 399 start-page: 784 year: 1999 end-page: 788 ident: CR36 article-title: The prolyl isomerase Pin1 restores the function of Alzheimer‐associated phosphorylated tau protein publication-title: Nature – volume: 149 start-page: 232 year: 2012 end-page: 244 ident: CR41 article-title: Proline isomer‐specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease publication-title: Cell – volume: 534 start-page: 267 year: 2016 end-page: 271 ident: CR14 article-title: The Brazilian Zika virus strain causes birth defects in experimental models publication-title: Nature – volume: 27 start-page: 125 year: 2020a end-page: 136 article-title: A human pluripotent stem cell‐based platform to study SARS‐CoV‐2 tropism and model virus infection in human cells and organoids publication-title: Cell Stem Cell – year: 2020 article-title: Early postmortem brain MRI findings in COVID‐19 non‐survivors publication-title: Neurology – volume: 545 start-page: 54 year: 2017 end-page: 59 article-title: Assembly of functionally integrated human forebrain spheroids publication-title: Nature – volume: 5 start-page: 85 year: 2016 end-page: 86 article-title: Determination of 50% endpoint titer using a simple formula publication-title: World J Virol – volume: 534 start-page: 267 year: 2016 end-page: 271 article-title: The Brazilian Zika virus strain causes birth defects in experimental models publication-title: Nature – volume: 11 start-page: 995 year: 2020 end-page: 998 article-title: Evidence of the COVID‐19 virus targeting the CNS: tissue distribution, host‐virus interaction, and proposed neurotropic mechanisms publication-title: ACS Chem Neurosci – volume: 296 start-page: E119 year: 2020 end-page: E120 article-title: COVID‐19‐associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features publication-title: Radiology – volume: 357 start-page: 299 year: 1998 end-page: 309 article-title: Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules publication-title: Arch Biochem Biophys – volume: 12 start-page: 365 year: 2007 end-page: 375 article-title: Earliest stages of tau conformational changes are related to the appearance of a sequence of specific phospho‐dependent tau epitopes in Alzheimer's disease publication-title: J Alzheimers Dis – volume: 6 start-page: eaay8828 year: 2020 article-title: A 3D human brain‐like tissue model of herpes‐induced Alzheimer's disease publication-title: Sci Adv – volume: 345 start-page: 1247125 year: 2014 article-title: Organogenesis in a dish: modeling development and disease using organoid technologies publication-title: Science – volume: 149 start-page: 232 year: 2012 end-page: 244 article-title: Proline isomer‐specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease publication-title: Cell – volume: 76 start-page: 233 year: 2020 end-page: 235 article-title: Guillain Barre syndrome associated with COVID‐19 infection: a case report publication-title: J Clin Neurosci – volume: 61 start-page: 557 year: 2002a end-page: 564 article-title: Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre‐neurofibrillary tangles and neurofibrillary tangles publication-title: J Neuropathol Exp Neurol – volume: 81 start-page: 813 year: 2007 end-page: 821 article-title: Lethal infection of K18‐hACE2 mice infected with severe acute respiratory syndrome coronavirus publication-title: J Virol – volume: 35 start-page: 803 year: 2016 end-page: 819 article-title: CPAP promotes timely cilium disassembly to maintain neural progenitor pool publication-title: EMBO J – year: 2020 article-title: Sofosbuvir protects human brain organoids against SARS‐CoV‐2 publication-title: BioRxiv – year: 2020 article-title: Neuroinvasive potential of SARS‐CoV‐2 revealed in a human brain organoid model publication-title: BioRxiv – volume: 31 start-page: 107738 year: 2020 article-title: Rapid and efficient invasion assay of glioblastoma in human brain organoids publication-title: Cell Rep – volume: 399 start-page: 784 year: 1999 end-page: 788 article-title: The prolyl isomerase Pin1 restores the function of Alzheimer‐associated phosphorylated tau protein publication-title: Nature – volume: 285 start-page: 30851 year: 2010 end-page: 30860 article-title: Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration publication-title: J Biol Chem – volume: 426 start-page: 450 year: 2003 end-page: 454 article-title: Angiotensin‐converting enzyme 2 is a functional receptor for the SARS coronavirus publication-title: Nature – year: 2020 article-title: On the calculation of TCID50 for quantitation of virus infectivity publication-title: Virol Sin – volume: 165 start-page: 1238 year: 2016 end-page: 1254 article-title: Brain‐region‐specific organoids using mini‐bioreactors for modeling ZIKV exposure publication-title: Cell – volume: 383 start-page: 590 year: 2020 end-page: 592 article-title: Multiorgan and renal tropism of SARS‐CoV‐2 publication-title: N Engl J Med – volume: 22 start-page: 669 year: 2019 end-page: 679 article-title: Cerebral organoids at the air‐liquid interface generate diverse nerve tracts with functional output publication-title: Nat Neurosci – volume: 2 start-page: 252 year: 2011 article-title: The acetylation of tau inhibits its function and promotes pathological tau aggregation publication-title: Nat Commun – volume: 11 start-page: 665 year: 2018 end-page: 680 article-title: Characterization and transplantation of CD73‐positive photoreceptors isolated from human iPSC‐derived retinal organoids publication-title: Stem Cell Reports – year: 2015 – volume: 122 start-page: 55372 year: 2017 article-title: Generation of iPSC‐derived human brain organoids to model early neurodevelopmental disorders publication-title: J Vis Exp – volume: 88 start-page: 349 year: 2004 end-page: 358 article-title: Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules publication-title: J Neurochem – volume: 43 start-page: 355 year: 2020 end-page: 357 article-title: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and the central nervous system publication-title: Trends Neurosci – volume: 25 start-page: 46 year: 2015 end-page: 53 article-title: Connecting the dots between tau dysfunction and neurodegeneration publication-title: Trends Cell Biol – volume: 20 start-page: 397 year: 2017 end-page: 406 article-title: Recent zika virus isolates induce premature differentiation of neural progenitors in human brain organoids publication-title: Cell Stem Cell – volume: 25 start-page: 2000045 year: 2020 article-title: Detection of 2019 novel coronavirus (2019‐nCoV) by real‐time RT‐PCR publication-title: Euro Surveill – volume: 20 start-page: e00771 year: 2020 article-title: Guillain‐Barre Syndrome associated with SARS‐CoV‐2 infection publication-title: IDCases – volume: 44 start-page: 36 year: 2017 end-page: 43 article-title: Probing human brain evolution and development in organoids publication-title: Curr Opin Cell Biol – volume: 103 start-page: 26 year: 2002b end-page: 35 article-title: Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease publication-title: Acta Neuropathol – volume: 12 start-page: 95 year: 2012 article-title: Use of anionic denaturing detergents to purify insoluble proteins after overexpression publication-title: BMC Biotechnol – volume: 382 start-page: 2268 year: 2020 end-page: 2270 article-title: Neurologic features in severe SARS‐CoV‐2 infection publication-title: N Engl J Med – volume: 406 start-page: 74 year: 2000 end-page: 78 article-title: Initiation of neural induction by FGF signalling before gastrulation publication-title: Nature – volume: 44 start-page: 250 year: 2008 end-page: 254 article-title: Analysis of apoptosis by cytometry using TUNEL assay publication-title: Methods – volume: 369 start-page: 50 year: 2020 end-page: 54 article-title: SARS‐CoV‐2 productively infects human gut enterocytes publication-title: Science – volume: 26 start-page: 1077 year: 2020 end-page: 1083 article-title: Infection of bat and human intestinal organoids by SARS‐CoV‐2 publication-title: Nat Med – volume: 368 start-page: m1091 year: 2020 article-title: Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study publication-title: BMJ – volume: 181 start-page: 271 year: 2020 end-page: 280 article-title: SARS‐CoV‐2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor publication-title: Cell – volume: 17 start-page: 5 year: 2016 end-page: 21 article-title: Tau in physiology and pathology publication-title: Nat Rev Neurosci – year: 2020 – volume: 67 start-page: 447 year: 2019 end-page: 467 article-title: Tau biology, tauopathy, traumatic brain injury, and diagnostic challenges publication-title: J Alzheimers Dis – volume: 181 start-page: 905 year: 2020 end-page: 913.e7 article-title: Inhibition of SARS‐CoV‐2 infections in engineered human tissues using clinical‐grade soluble human ACE2 publication-title: Cell – volume: 501 start-page: 373 year: 2013 end-page: 379 article-title: Cerebral organoids model human brain development and microcephaly publication-title: Nature – volume: 41 start-page: e1900011 year: 2019 article-title: The emergence of stem cell‐based brain organoids: trends and challenges phosphorylates publication-title: BioEssays – volume: 523 start-page: 431 year: 2015 end-page: 436 article-title: Antibody against early driver of neurodegeneration cis P‐tau blocks brain injury and tauopathy publication-title: Nature – volume: 21 start-page: 383 year: 2017 end-page: 398 article-title: Fusion of regionally specified hPSC‐derived organoids models human brain development and interneuron migration publication-title: Cell Stem Cell – volume: 8 start-page: 475 year: 2020b end-page: 481 article-title: Clinical course and outcomes of critically ill patients with SARS‐CoV‐2 pneumonia in Wuhan, China: a single‐centered, retrospective, observational study publication-title: Lancet Respir Med – volume: 37 start-page: 721 year: 2014 end-page: 32 article-title: Lost after translation: missorting of Tau protein and consequences for Alzheimer disease publication-title: Trends Neurosci – volume: 412 start-page: 116824 year: 2020 article-title: Neurotropism of SARS‐CoV 2: mechanisms and manifestations publication-title: J Neurol Sci – volume: 72 start-page: 1559 year: 2015 end-page: 1576 article-title: Retinoic acid signaling and neuronal differentiation publication-title: Cell Mol Life Sci – ident: e_1_2_9_55_1 doi: 10.1016/j.stem.2017.07.007 – ident: e_1_2_9_6_1 doi: 10.1038/nature22330 – ident: e_1_2_9_19_1 doi: 10.1016/j.tcb.2014.07.005 – ident: e_1_2_9_36_1 doi: 10.1038/nature02145 – ident: e_1_2_9_4_1 doi: 10.1007/s004010100423 – ident: e_1_2_9_2_1 doi: 10.1074/jbc.M110.110957 – volume: 122 start-page: 55372 year: 2017 ident: e_1_2_9_21_1 article-title: Generation of iPSC‐derived human brain organoids to model early neurodevelopmental disorders publication-title: J Vis Exp – ident: e_1_2_9_39_1 doi: 10.1128/JVI.02012-06 – ident: e_1_2_9_46_1 doi: 10.5501/wjv.v5.i2.85 – ident: e_1_2_9_32_1 doi: 10.1126/science.abc1669 – ident: e_1_2_9_10_1 doi: 10.1111/j.1471-4159.2004.02155.x – ident: e_1_2_9_23_1 doi: 10.1016/j.stemcr.2018.07.005 – ident: e_1_2_9_43_1 doi: 10.1148/radiol.2020201187 – ident: e_1_2_9_53_1 doi: 10.1038/nrn.2015.1 – ident: e_1_2_9_12_1 doi: 10.1016/j.jns.2020.116824 – ident: e_1_2_9_30_1 doi: 10.1007/s00018-014-1815-9 – ident: e_1_2_9_33_1 doi: 10.1038/nature12517 – ident: e_1_2_9_11_1 doi: 10.1038/ncomms1255 – ident: e_1_2_9_16_1 doi: 10.1016/j.ymeth.2007.11.008 – ident: e_1_2_9_27_1 doi: 10.1016/j.celrep.2020.107738 – ident: e_1_2_9_17_1 doi: 10.1016/j.tins.2020.04.004 – ident: e_1_2_9_51_1 doi: 10.1038/35017617 – ident: e_1_2_9_26_1 doi: 10.1002/bies.201900011 – ident: e_1_2_9_31_1 doi: 10.1038/nature14658 – year: 2020 ident: e_1_2_9_35_1 article-title: On the calculation of TCID50 for quantitation of virus infectivity publication-title: Virol Sin – ident: e_1_2_9_57_1 doi: 10.1016/S2213-2600(20)30079-5 – ident: e_1_2_9_3_1 doi: 10.1093/jnen/61.6.557 – ident: e_1_2_9_13_1 doi: 10.1212/WNL.0000000000010116 – ident: e_1_2_9_24_1 doi: 10.1016/j.ceb.2017.01.001 – ident: e_1_2_9_28_1 doi: 10.1056/NEJMc2008597 – ident: e_1_2_9_59_1 doi: 10.1038/s41591-020-0912-6 – ident: e_1_2_9_8_1 doi: 10.3233/JAD-180721 – ident: e_1_2_9_47_1 doi: 10.1186/1472-6750-12-95 – ident: e_1_2_9_37_1 doi: 10.1038/21650 – year: 2020 ident: e_1_2_9_40_1 article-title: Sofosbuvir protects human brain organoids against SARS‐CoV‐2 publication-title: BioRxiv – ident: e_1_2_9_54_1 – ident: e_1_2_9_42_1 doi: 10.1016/j.cell.2012.02.016 – ident: e_1_2_9_18_1 doi: 10.1128/9781555819521 – ident: e_1_2_9_45_1 doi: 10.1016/j.cell.2016.04.032 – ident: e_1_2_9_52_1 doi: 10.1016/j.idcr.2020.e00771 – year: 2020 ident: e_1_2_9_50_1 article-title: Neuroinvasive potential of SARS‐CoV‐2 revealed in a human brain organoid model publication-title: BioRxiv – ident: e_1_2_9_38_1 doi: 10.3233/JAD-2007-12410 – ident: e_1_2_9_41_1 doi: 10.1016/j.cell.2020.04.004 – ident: e_1_2_9_25_1 doi: 10.1038/s41593-019-0350-2 – ident: e_1_2_9_56_1 doi: 10.1016/j.stem.2020.06.015 – ident: e_1_2_9_9_1 doi: 10.1136/bmj.m1091 – ident: e_1_2_9_49_1 doi: 10.1006/abbi.1998.0813 – ident: e_1_2_9_15_1 doi: 10.1038/nature18296 – ident: e_1_2_9_44_1 doi: 10.1056/NEJMc2011400 – ident: e_1_2_9_22_1 doi: 10.1016/j.stem.2016.12.005 – ident: e_1_2_9_20_1 doi: 10.15252/embj.201593679 – ident: e_1_2_9_14_1 doi: 10.2807/1560-7917.ES.2020.25.3.2000045 – ident: e_1_2_9_34_1 doi: 10.1126/science.1247125 – ident: e_1_2_9_58_1 doi: 10.1016/j.tins.2014.08.004 – ident: e_1_2_9_5_1 doi: 10.1021/acschemneuro.0c00122 – ident: e_1_2_9_7_1 doi: 10.1126/sciadv.aay8828 – ident: e_1_2_9_29_1 doi: 10.1016/j.cell.2020.02.052 – ident: e_1_2_9_48_1 doi: 10.1016/j.jocn.2020.04.062
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Snippet	COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency. COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical... COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical...
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SubjectTerms	Abnormalities Animals Axons Betacoronavirus - physiology Brain Brain - virology brain organoids Cell Death Central nervous system Chlorocebus aethiops Coronaviruses COVID-19 EMBO23 EMBO24 EMBO27 Exposure Humans Life Sciences Nervous system Nervous System Diseases - virology Neuroimaging Neurons Neurons - virology Neurotoxicity Organoids Pandemics Phosphorylation Public health SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Tau pathology Tau protein tau Proteins - metabolism Tropism Vero Cells Viral diseases
Title	SARS‐CoV‐2 targets neurons of 3D human brain organoids
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