Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes
Nuclear pore complexes have recently been shown to play roles in gene activation; however their potential involvement in metazoan transcription remains unclear. Here we show that the nucleoporins Sec13, Nup98, and Nup88, as well as a group of FG-repeat nucleoporins, bind to the Drosophila genome at...
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| Vydané v: | Cell Ročník 140; číslo 3; s. 372 |
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| Hlavní autori: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
05.02.2010
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| ISSN: | 1097-4172, 1097-4172 |
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| Abstract | Nuclear pore complexes have recently been shown to play roles in gene activation; however their potential involvement in metazoan transcription remains unclear. Here we show that the nucleoporins Sec13, Nup98, and Nup88, as well as a group of FG-repeat nucleoporins, bind to the Drosophila genome at functionally distinct loci that often do not represent nuclear envelope contact sites. Whereas Nup88 localizes to silent loci, Sec13, Nup98, and a subset of FG-repeat nucleoporins bind to developmentally regulated genes undergoing transcription induction. Strikingly, RNAi-mediated knockdown of intranuclear Sec13 and Nup98 specifically inhibits transcription of their target genes and prevents efficient reactivation of transcription after heat shock, suggesting an essential role of NPC components in regulating complex gene expression programs of multicellular organisms. |
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| AbstractList | Nuclear pore complexes have recently been shown to play roles in gene activation; however their potential involvement in metazoan transcription remains unclear. Here we show that the nucleoporins Sec13, Nup98, and Nup88, as well as a group of FG-repeat nucleoporins, bind to the Drosophila genome at functionally distinct loci that often do not represent nuclear envelope contact sites. Whereas Nup88 localizes to silent loci, Sec13, Nup98, and a subset of FG-repeat nucleoporins bind to developmentally regulated genes undergoing transcription induction. Strikingly, RNAi-mediated knockdown of intranuclear Sec13 and Nup98 specifically inhibits transcription of their target genes and prevents efficient reactivation of transcription after heat shock, suggesting an essential role of NPC components in regulating complex gene expression programs of multicellular organisms. Nuclear pore complexes have recently been shown to play roles in gene activation; however their potential involvement in metazoan transcription remains unclear. Here we show that the nucleoporins Sec13, Nup98, and Nup88, as well as a group of FG-repeat nucleoporins, bind to the Drosophila genome at functionally distinct loci that often do not represent nuclear envelope contact sites. Whereas Nup88 localizes to silent loci, Sec13, Nup98, and a subset of FG-repeat nucleoporins bind to developmentally regulated genes undergoing transcription induction. Strikingly, RNAi-mediated knockdown of intranuclear Sec13 and Nup98 specifically inhibits transcription of their target genes and prevents efficient reactivation of transcription after heat shock, suggesting an essential role of NPC components in regulating complex gene expression programs of multicellular organisms.Nuclear pore complexes have recently been shown to play roles in gene activation; however their potential involvement in metazoan transcription remains unclear. Here we show that the nucleoporins Sec13, Nup98, and Nup88, as well as a group of FG-repeat nucleoporins, bind to the Drosophila genome at functionally distinct loci that often do not represent nuclear envelope contact sites. Whereas Nup88 localizes to silent loci, Sec13, Nup98, and a subset of FG-repeat nucleoporins bind to developmentally regulated genes undergoing transcription induction. Strikingly, RNAi-mediated knockdown of intranuclear Sec13 and Nup98 specifically inhibits transcription of their target genes and prevents efficient reactivation of transcription after heat shock, suggesting an essential role of NPC components in regulating complex gene expression programs of multicellular organisms. |
| Author | Mair, William Hetzer, Martin W Schulte, Roberta Wagner, Ulrich Capelson, Maya Liang, Yun |
| Author_xml | – sequence: 1 givenname: Maya surname: Capelson fullname: Capelson, Maya organization: Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA – sequence: 2 givenname: Yun surname: Liang fullname: Liang, Yun – sequence: 3 givenname: Roberta surname: Schulte fullname: Schulte, Roberta – sequence: 4 givenname: William surname: Mair fullname: Mair, William – sequence: 5 givenname: Ulrich surname: Wagner fullname: Wagner, Ulrich – sequence: 6 givenname: Martin W surname: Hetzer fullname: Hetzer, Martin W |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20144761$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Chromatin - metabolism Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Gene Expression Regulation Heat-Shock Response Nuclear Pore Complex Proteins - metabolism RNA Polymerase II - metabolism Transcription, Genetic |
| Title | Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/20144761 https://www.proquest.com/docview/734289391 |
| Volume | 140 |
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