A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function

Heart diseases are the most common causes of morbidity and death in humans. Using cardiac-specific RNAi-silencing in Drosophila, we knocked down 7061 evolutionarily conserved genes under conditions of stress. We present a first global roadmap of pathways potentially playing conserved roles in the ca...

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Vydané v:	Cell Ročník 141; číslo 1; s. 142
Hlavní autori:	Neely, G Gregory, Kuba, Keiji, Cammarato, Anthony, Isobe, Kazuya, Amann, Sabine, Zhang, Liyong, Murata, Mitsushige, Elmén, Lisa, Gupta, Vaijayanti, Arora, Suchir, Sarangi, Rinku, Dan, Debasis, Fujisawa, Susumu, Usami, Takako, Xia, Cui-ping, Keene, Alex C, Alayari, Nakissa N, Yamakawa, Hiroyuki, Elling, Ulrich, Berger, Christian, Novatchkova, Maria, Koglgruber, Rubina, Fukuda, Keiichi, Nishina, Hiroshi, Isobe, Mitsuaki, Pospisilik, J Andrew, Imai, Yumiko, Pfeufer, Arne, Hicks, Andrew A, Pramstaller, Peter P, Subramaniam, Sai, Kimura, Akinori, Ocorr, Karen, Bodmer, Rolf, Penninger, Josef M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 02.04.2010
Predmet:	Animals Cardiomyopathies - genetics Cardiomyopathies - physiopathology Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - physiology Female Genome-Wide Association Study Heart - embryology Heart - physiology Humans Male Mice Mice, Knockout Models, Animal Promoter Regions, Genetic RNA Interference
ISSN:	1097-4172, 1097-4172
On-line prístup:	Zistit podrobnosti o prístupe
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