The immunopathology of sepsis and potential therapeutic targets

Key Points Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. The sepsis-associated host response is characterized by concurrent excessive inflammatory, catabolic, metabolic and immune-suppressive features, and a failure to return to homeostas...

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Bibliographic Details
Published in:	Nature reviews. Immunology Vol. 17; no. 7; pp. 407 - 420
Main Authors:	van der Poll, Tom, van de Veerdonk, Frank L., Scicluna, Brendon P., Netea, Mihai G.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.07.2017 Nature Publishing Group
Subjects:	631/250/256/1980 631/250/256/2516 Animals Bacterial Infections - immunology Bacterial Infections - metabolism Bacterial Infections - microbiology Bacterial Infections - pathology Biological markers Biomedicine Care and treatment Epigenomics Health aspects Homeostasis Humans Immune response Immunology Inflammation Microbiota Pathogens review-article Sepsis Sepsis - immunology Sepsis - metabolism Sepsis - microbiology Sepsis - pathology Transcription, Genetic
ISSN:	1474-1733, 1474-1741, 1474-1741
Online Access:	Get full text
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