Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial

ABSTRACT Background Epidemiological studies have shown that increased circulating branched-chain amino acids (BCAAs) are associated with insulin resistance and type 2 diabetes (T2D). This may result from altered energy metabolism or dietary habits. Objective We hypothesized that a lower intake of BC...

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Bibliographic Details
Published in:	The American journal of clinical nutrition Vol. 110; no. 5; pp. 1098 - 1107
Main Authors:	Karusheva, Yanislava, Koessler, Theresa, Strassburger, Klaus, Markgraf, Daniel, Mastrototaro, Lucia, Jelenik, Tomas, Simon, Marie-Christine, Pesta, Dominik, Zaharia, Oana-Patricia, Bódis, Kálmán, Bärenz, Felix, Schmoll, Dieter, Wolkersdorfer, Martin, Tura, Andrea, Pacini, Giovanni, Burkart, Volker, Müssig, Karsten, Szendroedi, Julia, Roden, Michael
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 01.11.2019
Subjects:	Adipose Tissue, White - metabolism Amino Acids, Branched-Chain - administration & dosage Cross-Over Studies Diabetes Mellitus, Type 2 - microbiology Double-Blind Method Female Gastrointestinal Microbiome Humans Insulin Secretion Male Meals Middle Aged Mitochondria - physiology Muscle, Skeletal - metabolism insulin sensitivity mitochondrial function gut microbiome patients with type 2 diabetes diet insulin secretion branched-chain amino acids
ISSN:	0002-9165, 1938-3207, 1938-3207
Online Access:	Get full text
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