Overexpression of miR-422a inhibits cell proliferation and invasion, and enhances chemosensitivity in osteosarcoma cells

Osteosarcoma (OS) is an aggressive malignant tumor that is mesenchymal in origin with a very low 5-year survival rate, particularly in the patients with locally advanced or metastatic tumors and recurrent disease. MicroRNAs (miRNAs) play a critical role in essential biological processes as cellular...

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Bibliographic Details
Published in:	Oncology reports Vol. 36; no. 6; pp. 3371 - 3378
Main Authors:	Liu, Mingjiang, Xiusheng, He, Xiao, Xiangjun, Wang, Yichun
Format:	Journal Article
Language:	English
Published:	Greece D.A. Spandidos 01.12.2016 Spandidos Publications Spandidos Publications UK Ltd
Subjects:	3' Untranslated Regions Antineoplastic Agents - pharmacology Apoptosis Base Sequence Binding Sites Bone cancer Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - metabolism Cancer therapies Care and treatment Cell growth Cell Line, Tumor Cell Movement Cell Proliferation chemosensitivity Chemotherapy Cisplatin - pharmacology Colorectal cancer Development and progression Gene Expression Gene Expression Regulation, Neoplastic Genetic aspects Growth factors Health aspects Humans Innovations Kinases Medical prognosis Membranes Metastasis MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Molecular targeted therapy Neoplasm Invasiveness Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - genetics Osteosarcoma - metabolism Paclitaxel - pharmacology Pathogenesis Proteins RNA Interference Sarcoma smad Transforming Growth Factor beta2 - genetics Transforming Growth Factor beta2 - metabolism transforming growth factorβ2 United States > US China
ISSN:	1021-335X, 1791-2431, 1791-2431
Online Access:	Get full text
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