Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function

Metabolic synergy or metabolic coupling between glycolytic stromal cells (Warburg effect) and oxidative cancer cells occurs in human breast cancers and promotes tumor growth. The Warburg effect or aerobic glycolysis is the catabolism of glucose to lactate to obtain adenosine triphosphate (ATP). This...

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Bibliographic Details
Published in:	Seminars in oncology Vol. 41; no. 2; p. 195
Main Authors:	Martinez-Outschoorn, Ubaldo, Sotgia, Federica, Lisanti, Michael P
Format:	Journal Article
Language:	English
Published:	United States 01.04.2014
Subjects:	Animals Autophagy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cachexia - physiopathology Carcinoma - metabolism Caveolin 1 - metabolism Cell Line, Tumor Cell Transformation, Neoplastic Female Fibroblasts - metabolism Glycolysis Humans Lactic Acid - metabolism Mitochondria - metabolism Oxidative Stress Phenotype Reactive Oxygen Species - metabolism Signal Transduction Stromal Cells - cytology Tumor Microenvironment
ISSN:	1532-8708, 1532-8708
Online Access:	Get more information
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