Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans

The sterol regulatory element binding proteins (SREBPs) are transcription factors that govern cholesterol and fatty acid metabolism. We recently identified SPRING as a post-transcriptional regulator of SREBP activation. Constitutive or inducible global ablation of Spring in mice is not tolerated, an...

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Veröffentlicht in:	Nature communications Jg. 14; H. 1; S. 5181 - 15
Hauptverfasser:	Hendrix, Sebastian, Kingma, Jenina, Ottenhoff, Roelof, Valiloo, Masoud, Svecla, Monika, Zijlstra, Lobke F., Sachdev, Vinay, Kovac, Kristina, Levels, Johannes H. M., Jongejan, Aldo, de Boer, Jan F., Kuipers, Folkert, Rimbert, Antoine, Norata, Giuseppe D., Loregger, Anke, Zelcer, Noam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 25.08.2023 Nature Publishing Group Nature Portfolio
Schlagworte:	13/1 13/106 14/63 38/39 38/43 38/77 38/90 38/91 45/41 631/208/457/649 631/443/319/1642 631/45/287/1183 631/45/287/1191 631/45/287/1197 64/60 82/58 82/80 96 Ablation Animals Biosynthesis Cholesterol Diet Fatty acids Female Genetic diversity Hepatocytes High density High density lipoprotein Humanities and Social Sciences Humans Life Sciences Lipid Metabolism Lipids Lipoproteins Lipoproteins, HDL Liver Male Metabolism Mice multidisciplinary Post-transcription Proteomics Regulatory sequences Science Science (multidisciplinary) Steatosis Sterol Regulatory Element Binding Protein 1 Sterol regulatory element-binding protein Transcription factors Transcriptomics Triglycerides
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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