Chromatin organization drives the search mechanism of nuclear factors

Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization in such search is uncharted. Here we analyzed how multiple factors explore chromatin, combining live-cell single-molecule tracking with multifocal structured illumination of DNA density. We find that fact...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 6433 - 17
Main Authors:	Mazzocca, Matteo, Loffreda, Alessia, Colombo, Emanuele, Fillot, Tom, Gnani, Daniela, Falletta, Paola, Monteleone, Emanuele, Capozi, Serena, Bertrand, Edouard, Legube, Gaelle, Lavagnino, Zeno, Tacchetti, Carlo, Mazza, Davide
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.10.2023 Nature Publishing Group Nature Portfolio
Subjects:	14/32 14/63 631/1647/328 631/337/386 631/57/2265 64 Chromatin Deoxyribonucleic acid DNA Gene mapping Genomes Humanities and Social Sciences Image resolution Life Sciences Low concentrations multidisciplinary Nuclei (cytology) p53 Protein Science Science (multidisciplinary) Searching Tracking
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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