Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1
The hyaluronan receptor LYVE-1 is expressed abundantly on the surfaces of lymphatic vessels and lymph node sinus endothelial cells from early development, where it has been suggested to function both in cell adhesion/transmigration and as a scavenger for hyaluronan turnover. To investigate the physi...
Uloženo v:
| Vydáno v: | Molecular and cellular biology Ročník 27; číslo 2; s. 595 |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
01.01.2007
|
| Témata: | |
| ISSN: | 0270-7306 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | The hyaluronan receptor LYVE-1 is expressed abundantly on the surfaces of lymphatic vessels and lymph node sinus endothelial cells from early development, where it has been suggested to function both in cell adhesion/transmigration and as a scavenger for hyaluronan turnover. To investigate the physiological role(s) of LYVE-1, we generated mice in which the gene for the receptor was inactivated by replacement with a beta-galactosidase reporter. LYVE-1(-/-) mice displayed an apparently normal phenotype, with no obvious alteration in lymphatic vessel ultrastructure or function and no apparent change in secondary lymphoid tissue structure or cellularity. In addition, the levels of hyaluronan in tissue and blood were unchanged. LYVE-1(-/-) mice also displayed normal trafficking of cutaneous CD11c(+) dendritic cells to draining lymph nodes via afferent lymphatics and normal resolution of oxazolone-induced skin inflammation. Finally, LYVE-1(-/-) mice supported normal growth of transplanted B16F10 melanomas and Lewis lung carcinomas. These results indicate that LYVE-1 is not obligatory for normal lymphatic development and function and suggest either the existence of compensatory receptors or a role more specific than that previously envisaged. |
|---|---|
| AbstractList | The hyaluronan receptor LYVE-1 is expressed abundantly on the surfaces of lymphatic vessels and lymph node sinus endothelial cells from early development, where it has been suggested to function both in cell adhesion/transmigration and as a scavenger for hyaluronan turnover. To investigate the physiological role(s) of LYVE-1, we generated mice in which the gene for the receptor was inactivated by replacement with a beta-galactosidase reporter. LYVE-1(-/-) mice displayed an apparently normal phenotype, with no obvious alteration in lymphatic vessel ultrastructure or function and no apparent change in secondary lymphoid tissue structure or cellularity. In addition, the levels of hyaluronan in tissue and blood were unchanged. LYVE-1(-/-) mice also displayed normal trafficking of cutaneous CD11c(+) dendritic cells to draining lymph nodes via afferent lymphatics and normal resolution of oxazolone-induced skin inflammation. Finally, LYVE-1(-/-) mice supported normal growth of transplanted B16F10 melanomas and Lewis lung carcinomas. These results indicate that LYVE-1 is not obligatory for normal lymphatic development and function and suggest either the existence of compensatory receptors or a role more specific than that previously envisaged. The hyaluronan receptor LYVE-1 is expressed abundantly on the surfaces of lymphatic vessels and lymph node sinus endothelial cells from early development, where it has been suggested to function both in cell adhesion/transmigration and as a scavenger for hyaluronan turnover. To investigate the physiological role(s) of LYVE-1, we generated mice in which the gene for the receptor was inactivated by replacement with a beta-galactosidase reporter. LYVE-1(-/-) mice displayed an apparently normal phenotype, with no obvious alteration in lymphatic vessel ultrastructure or function and no apparent change in secondary lymphoid tissue structure or cellularity. In addition, the levels of hyaluronan in tissue and blood were unchanged. LYVE-1(-/-) mice also displayed normal trafficking of cutaneous CD11c(+) dendritic cells to draining lymph nodes via afferent lymphatics and normal resolution of oxazolone-induced skin inflammation. Finally, LYVE-1(-/-) mice supported normal growth of transplanted B16F10 melanomas and Lewis lung carcinomas. These results indicate that LYVE-1 is not obligatory for normal lymphatic development and function and suggest either the existence of compensatory receptors or a role more specific than that previously envisaged.The hyaluronan receptor LYVE-1 is expressed abundantly on the surfaces of lymphatic vessels and lymph node sinus endothelial cells from early development, where it has been suggested to function both in cell adhesion/transmigration and as a scavenger for hyaluronan turnover. To investigate the physiological role(s) of LYVE-1, we generated mice in which the gene for the receptor was inactivated by replacement with a beta-galactosidase reporter. LYVE-1(-/-) mice displayed an apparently normal phenotype, with no obvious alteration in lymphatic vessel ultrastructure or function and no apparent change in secondary lymphoid tissue structure or cellularity. In addition, the levels of hyaluronan in tissue and blood were unchanged. LYVE-1(-/-) mice also displayed normal trafficking of cutaneous CD11c(+) dendritic cells to draining lymph nodes via afferent lymphatics and normal resolution of oxazolone-induced skin inflammation. Finally, LYVE-1(-/-) mice supported normal growth of transplanted B16F10 melanomas and Lewis lung carcinomas. These results indicate that LYVE-1 is not obligatory for normal lymphatic development and function and suggest either the existence of compensatory receptors or a role more specific than that previously envisaged. |
| Author | Dominguez, Melissa G Espinosa, Jorge Jackson, David G Ferguson, David J Thurston, Gavin Yancopoulos, George D Gale, Nicholas W Prevo, Remko |
| Author_xml | – sequence: 1 givenname: Nicholas W surname: Gale fullname: Gale, Nicholas W organization: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom – sequence: 2 givenname: Remko surname: Prevo fullname: Prevo, Remko – sequence: 3 givenname: Jorge surname: Espinosa fullname: Espinosa, Jorge – sequence: 4 givenname: David J surname: Ferguson fullname: Ferguson, David J – sequence: 5 givenname: Melissa G surname: Dominguez fullname: Dominguez, Melissa G – sequence: 6 givenname: George D surname: Yancopoulos fullname: Yancopoulos, George D – sequence: 7 givenname: Gavin surname: Thurston fullname: Thurston, Gavin – sequence: 8 givenname: David G surname: Jackson fullname: Jackson, David G |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17101772$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkD1PwzAYhD0U0RbYmJEntpTXH4nTEaryIRVYAIkpcuLXilFiBydB6r8niCIx3Un33A23JDMfPBJyzmDFGM-vHjc3K2ApiASyGVkAV5AoAdmcLPv-AwCyNYhjMmeKAVOKL0j9FGKrG9rs267Wg6uowS9sQteiH6j2htrRV4MLnjpPW1fhBFhXuZ_YhkiHGv-V671uxhi89jRihd0wEbv3t23CTsmR1U2PZwc9Ia-325fNfbJ7vnvYXO-SKk35kHAwazBSlKwEpcrMTl5KI3ILUqVKSDAGJTeZ1NIYa6UwBowCBRytVchPyOXvbhfD54j9ULSur7BptMcw9kWWi1yynE3gxQEcyxZN0UXX6rgv_r7h37X-ZlY |
| CitedBy_id | crossref_primary_10_1038_s41569_020_00489_x crossref_primary_10_1016_j_addr_2019_08_006 crossref_primary_10_1242_dev_132431 crossref_primary_10_1016_j_aanat_2008_03_013 crossref_primary_10_1172_JCI79693 crossref_primary_10_1196_annals_1413_019 crossref_primary_10_1089_lrb_2012_0019 crossref_primary_10_1196_annals_1413_011 crossref_primary_10_1182_blood_2012_08_450502 crossref_primary_10_1146_annurev_cellbio_111315_124944 crossref_primary_10_1074_jbc_M702889200 crossref_primary_10_1002_jcp_26159 crossref_primary_10_1016_j_matbio_2010_08_001 crossref_primary_10_1586_1744666X_4_5_599 crossref_primary_10_1038_s41598_019_47367_2 crossref_primary_10_1182_blood_2009_04_216069 crossref_primary_10_1196_annals_1413_006 crossref_primary_10_1007_s10719_015_9586_6 crossref_primary_10_1196_annals_1413_005 crossref_primary_10_3389_fphys_2019_01402 crossref_primary_10_1016_j_bbagen_2014_02_001 crossref_primary_10_1196_annals_1413_001 crossref_primary_10_1196_annals_1413_004 crossref_primary_10_1089_ten_teb_2016_0034 crossref_primary_10_1371_journal_pgen_1000073 crossref_primary_10_1016_j_mvr_2014_07_016 crossref_primary_10_1002_dvdy_21200 crossref_primary_10_1016_j_ajpath_2016_03_009 crossref_primary_10_3390_diagnostics12010004 crossref_primary_10_1007_s00418_008_0525_5 crossref_primary_10_1515_afmnai_2017_0003 crossref_primary_10_1161_01_RES_0000259564_92792_93 crossref_primary_10_1167_iovs_18_25920 crossref_primary_10_3390_pharmaceutics14040838 crossref_primary_10_1002_dvdy_21605 crossref_primary_10_1084_jem_20102392 crossref_primary_10_1002_art_38278 crossref_primary_10_1111_j_1440_1797_2009_01167_x crossref_primary_10_1172_JCI84549 crossref_primary_10_1038_s41581_021_00438_y crossref_primary_10_1007_s11906_020_01040_6 crossref_primary_10_1016_j_mvr_2014_07_001 crossref_primary_10_1292_jvms_21_0257 crossref_primary_10_1371_journal_ppat_1005137 crossref_primary_10_1038_ni_3750 crossref_primary_10_1038_emm_2014_72 crossref_primary_10_1016_j_survophthal_2021_03_007 crossref_primary_10_1111_j_1600_065X_2009_00803_x crossref_primary_10_1093_cvr_cvw175 crossref_primary_10_1016_j_coi_2018_04_027 crossref_primary_10_1089_lrb_2018_0023 crossref_primary_10_1007_s10456_013_9406_1 crossref_primary_10_1146_annurev_immunol_041015_055354 crossref_primary_10_1182_blood_2013_01_478941 crossref_primary_10_1016_j_actbio_2015_08_027 crossref_primary_10_1074_jbc_M115_683201 crossref_primary_10_3389_fimmu_2019_02700 crossref_primary_10_1002_ar_21043 crossref_primary_10_1089_lrb_2009_0003 crossref_primary_10_1089_lrb_2017_0052 crossref_primary_10_1002_wdev_246 crossref_primary_10_1371_journal_pone_0117352 crossref_primary_10_4049_jimmunol_1201371 crossref_primary_10_3390_jcm8040495 crossref_primary_10_1146_annurev_pathmechdis_3_121806_151515 crossref_primary_10_1186_s12935_022_02800_x crossref_primary_10_1089_lrb_2008_1008 crossref_primary_10_1016_j_aanat_2018_05_003 crossref_primary_10_1016_j_ijporl_2015_11_006 crossref_primary_10_1152_physrev_00052_2009 crossref_primary_10_2353_ajpath_2008_070360 crossref_primary_10_1016_j_actbio_2013_12_019 crossref_primary_10_1146_annurev_physiol_022516_034008 crossref_primary_10_1038_s44161_025_00711_4 crossref_primary_10_1146_annurev_cellbio_23_090506_123337 crossref_primary_10_1016_j_mam_2011_04_002 crossref_primary_10_1089_lrb_2007_5203 crossref_primary_10_1002_bdrc_20155 crossref_primary_10_1007_s00441_008_0644_2 crossref_primary_10_1242_dev_194563 crossref_primary_10_1089_scd_2009_0527 crossref_primary_10_1089_ten_teb_2015_0231 crossref_primary_10_1016_j_bbrc_2016_07_059 crossref_primary_10_1089_cbr_2014_1670 crossref_primary_10_1016_j_cell_2010_01_045 crossref_primary_10_1111_j_1582_4934_2009_00834_x crossref_primary_10_1007_BF03256244 crossref_primary_10_1093_molehr_gaq035 crossref_primary_10_3390_diagnostics12071624 crossref_primary_10_1016_j_theriogenology_2013_10_017 crossref_primary_10_1089_ten_teb_2017_0127 crossref_primary_10_3389_fimmu_2015_00236 crossref_primary_10_1007_s10456_021_09784_8 crossref_primary_10_1016_j_imbio_2008_07_025 crossref_primary_10_1089_scd_2014_0390 crossref_primary_10_1161_CIRCRESAHA_116_308504 crossref_primary_10_1016_j_pathophys_2009_09_003 crossref_primary_10_1182_blood_2011_12_396895 crossref_primary_10_1073_pnas_2317760121 crossref_primary_10_1182_blood_2007_10_120337 crossref_primary_10_1002_stem_2494 crossref_primary_10_1007_s00441_010_1098_x crossref_primary_10_1016_j_ajpath_2012_02_019 crossref_primary_10_1016_j_aanat_2018_02_011 crossref_primary_10_1073_pnas_1117560109 crossref_primary_10_1002_j_2040_4603_2023_tb00276_x crossref_primary_10_1002_jcp_21686 crossref_primary_10_1186_1471_2180_12_218 crossref_primary_10_1038_s44161_025_00707_0 crossref_primary_10_3109_10520295_2012_729864 crossref_primary_10_1016_j_immuni_2008_12_018 crossref_primary_10_1038_ncomms10824 crossref_primary_10_1016_j_immuni_2018_06_008 crossref_primary_10_1002_jcsm_70043 crossref_primary_10_3389_fimmu_2017_00104 crossref_primary_10_1002_ijc_27427 crossref_primary_10_1161_ATVBAHA_111_228999 crossref_primary_10_3389_fcell_2025_1537050 crossref_primary_10_1016_j_semcdb_2014_11_012 crossref_primary_10_1172_JCI97192 crossref_primary_10_1016_j_survophthal_2015_03_001 crossref_primary_10_1016_j_matbio_2018_02_001 crossref_primary_10_1111_cas_13755 crossref_primary_10_1111_gtc_12438 crossref_primary_10_3389_fphys_2020_00873 crossref_primary_10_1369_jhc_2010_956672 crossref_primary_10_1007_s00535_009_0152_5 crossref_primary_10_3390_jcdd8020021 crossref_primary_10_3892_mco_2017_1356 crossref_primary_10_1002_wsbm_1201 crossref_primary_10_1111_j_1349_7006_2008_00885_x crossref_primary_10_3389_fphys_2020_00509 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1128/MCB.01503-06 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Chemistry Biology |
| ExternalDocumentID | 17101772 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Medical Research Council grantid: MC_U137884182 |
| GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 18M 29M 2WC 39C 3O- 4.4 53G 5RE 5VS 9M8 AAGFI ABJNI ABRLO ACGFO ACKIV ACNCT ADBBV ADIYS ADXHL AENEX AEOZL AFFNX AGHSJ AGVNZ ALMA_UNASSIGNED_HOLDINGS AMPGV AOIJS BAWUL BTFSW C1A CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD EMOBN F5P GX1 H13 HH5 HYE HZ~ IH2 KQ8 L7B M4Z MVM N9A NPM O9- OK1 P2P RHI RNS RPM TDBHL TFL TFW TR2 UDS W8F WH7 WHG WOQ X7M Y6R YYP ZCA ZGI ZXP ZY4 7X8 TASJS |
| ID | FETCH-LOGICAL-c552t-20d90d43b1b077b6fd4344d38f04757340dde42d64a4ddff43dd0d70702eff7e2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 160 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000243353500015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0270-7306 |
| IngestDate | Thu Oct 02 03:49:20 EDT 2025 Fri May 30 11:00:56 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c552t-20d90d43b1b077b6fd4344d38f04757340dde42d64a4ddff43dd0d70702eff7e2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://doi.org/10.1128/MCB.01503-06 |
| PMID | 17101772 |
| PQID | 68384181 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_68384181 pubmed_primary_17101772 |
| PublicationCentury | 2000 |
| PublicationDate | 2007-01-01 |
| PublicationDateYYYYMMDD | 2007-01-01 |
| PublicationDate_xml | – month: 01 year: 2007 text: 2007-01-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Molecular and cellular biology |
| PublicationTitleAlternate | Mol Cell Biol |
| PublicationYear | 2007 |
| SSID | ssj0006903 |
| Score | 2.3033552 |
| Snippet | The hyaluronan receptor LYVE-1 is expressed abundantly on the surfaces of lymphatic vessels and lymph node sinus endothelial cells from early development,... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 595 |
| SubjectTerms | Animals beta-Galactosidase - genetics Carcinoma, Lewis Lung - pathology CD11c Antigen - metabolism Cell Movement Dendritic Cells - physiology Dermatitis, Contact - etiology Dermatitis, Contact - immunology Glycoproteins - genetics Glycoproteins - physiology Hyaluronic Acid - blood Hyaluronic Acid - metabolism Inflammation - chemically induced Inflammation - immunology Lymph Nodes - cytology Lymph Nodes - metabolism Lymph Nodes - physiology Lymphatic Vessels - cytology Lymphatic Vessels - metabolism Lymphatic Vessels - physiology Melanoma - pathology Membrane Transport Proteins Mice Mice, Knockout Neoplasm Transplantation Oxazolone |
| Title | Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1 |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/17101772 https://www.proquest.com/docview/68384181 |
| Volume | 27 |
| WOSCitedRecordID | wos000243353500015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEB6qVfTio77qcw9eY9Nkkk1AEC0tHmzpQaWeSpLdpYWS1j6E_ntnkoZ6EQ9eQiDZkOzMfvvN7GY-gFst0Qtj6VmJbzhbhWiFCRKRQ5N40q7Hvs7FJmSnE_R6YbcE98W_MLytssDEDKjVOOEcec0P3ABpOnqYfFqsGcVrqysBjQ0ou0Rk2Kdlb10rnOK-bH3ZkbZFfuwX296doNZuPN1xqM_CBr9Ty2yKae3_7-UOYG9FLcVj7guHUNJpBbZzscllBXYahbbbEQw6TFVHYrQkY3LNVqHWm4dElCrB8x3bTAxTwYr1dAPXmuDLRHMF0cYfjQfLaLSYEqdPBQGonlAcL14-3ptW_RjeWs3XxrO10lywEs9z5jRoVGgrdON6bEsZ-4bOEZUbGBulJ120CQ_RUT5GqJQx6CplK0nA4WhjpHZOYDMdp_oMBMY0vslBAh2HKF0VoY7pIZoIQhg5oazCTdGZffp8XqiIUj1ezPpFd1bhNLdHf5KX3ujXJUOIdM7_bHsBu3kalrMll1A2NJr1FWwlX_PhbHqduQodO932Ny_CyTU |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Normal+lymphatic+development+and+function+in+mice+deficient+for+the+lymphatic+hyaluronan+receptor+LYVE-1&rft.jtitle=Molecular+and+cellular+biology&rft.au=Gale%2C+Nicholas+W&rft.au=Prevo%2C+Remko&rft.au=Espinosa%2C+Jorge&rft.au=Ferguson%2C+David+J&rft.date=2007-01-01&rft.issn=0270-7306&rft.volume=27&rft.issue=2&rft.spage=595&rft_id=info:doi/10.1128%2FMCB.01503-06&rft_id=info%3Apmid%2F17101772&rft_id=info%3Apmid%2F17101772&rft.externalDocID=17101772 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-7306&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-7306&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-7306&client=summon |