The effect of enalapril on cardiac mechanics in the pediatric heart network infant single-ventricle trial: Insights using noninvasive pressure-volume loop analysis
Patients with single-ventricle physiology who received enalapril in the Pediatric Heart Network Infant Single-ventricle Trial displayed no differences in heart failure outcomes compared to those who received a placebo. The objective of this study was to use noninvasive pressure-volume loop analysis...
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| Vydané v: | Annals of pediatric cardiology Ročník 18; číslo 2; s. 142 - 144 |
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| Hlavní autori: | , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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India
Wolters Kluwer - Medknow
01.03.2025
Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Wolters Kluwer Medknow Publications |
| Vydanie: | 2 |
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| ISSN: | 0974-2069, 0974-5149 |
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| Abstract | Patients with single-ventricle physiology who received enalapril in the Pediatric Heart Network Infant Single-ventricle Trial displayed no differences in heart failure outcomes compared to those who received a placebo. The objective of this study was to use noninvasive pressure-volume loop analysis to assess for differences in cardiac mechanics between the enalapril and placebo groups. Core-lab echocardiogram measures prior to superior cavopulmonary connection (SCPC) and post-SCPC at 14 months of age were obtained. End-systolic elastance (Ees), a measure of contractility, and arterial elastance (Ea), a measure of afterload, were calculated. Ventriculo-arterial coupling was expressed as Ea/Ees. Data from 150 patients were analyzed. There was no difference in Ees, Ea, or Ea/Ees between study groups at either time point. The failure of enalapril to improve heart failure outcomes in this cohort may have some association with its failure to improve cardiac mechanics in single-ventricle physiology. |
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| AbstractList | Patients with single-ventricle physiology who received enalapril in the Pediatric Heart Network Infant Single-ventricle Trial displayed no differences in heart failure outcomes compared to those who received a placebo. The objective of this study was to use noninvasive pressure-volume loop analysis to assess for differences in cardiac mechanics between the enalapril and placebo groups. Core-lab echocardiogram measures prior to superior cavopulmonary connection (SCPC) and post-SCPC at 14 months of age were obtained. End-systolic elastance (Ees), a measure of contractility, and arterial elastance (Ea), a measure of afterload, were calculated. Ventriculo-arterial coupling was expressed as Ea/Ees. Data from 150 patients were analyzed. There was no difference in Ees, Ea, or Ea/Ees between study groups at either time point. The failure of enalapril to improve heart failure outcomes in this cohort may have some association with its failure to improve cardiac mechanics in single-ventricle physiology. Patients with single-ventricle physiology who received enalapril in the Pediatric Heart Network Infant Single-ventricle Trial displayed no differences in heart failure outcomes compared to those who received a placebo. The objective of this study was to use noninvasive pressure-volume loop analysis to assess for differences in cardiac mechanics between the enalapril and placebo groups. Core-lab echocardiogram measures prior to superior cavopulmonary connection (SCPC) and post-SCPC at 14 months of age were obtained. End-systolic elastance (Ees), a measure of contractility, and arterial elastance (Ea), a measure of afterload, were calculated. Ventriculo-arterial coupling was expressed as Ea/Ees. Data from 150 patients were analyzed. There was no difference in Ees, Ea, or Ea/Ees between study groups at either time point. The failure of enalapril to improve heart failure outcomes in this cohort may have some association with its failure to improve cardiac mechanics in single-ventricle physiology.Patients with single-ventricle physiology who received enalapril in the Pediatric Heart Network Infant Single-ventricle Trial displayed no differences in heart failure outcomes compared to those who received a placebo. The objective of this study was to use noninvasive pressure-volume loop analysis to assess for differences in cardiac mechanics between the enalapril and placebo groups. Core-lab echocardiogram measures prior to superior cavopulmonary connection (SCPC) and post-SCPC at 14 months of age were obtained. End-systolic elastance (Ees), a measure of contractility, and arterial elastance (Ea), a measure of afterload, were calculated. Ventriculo-arterial coupling was expressed as Ea/Ees. Data from 150 patients were analyzed. There was no difference in Ees, Ea, or Ea/Ees between study groups at either time point. The failure of enalapril to improve heart failure outcomes in this cohort may have some association with its failure to improve cardiac mechanics in single-ventricle physiology. Patients with single-ventricle physiology who received enalapril in the Pediatric Heart Network Infant Single-ventricle Trial displayed no differences in heart failure outcomes compared to those who received a placebo. The objective of this study was to use noninvasive pressure-volume loop analysis to assess for differences in cardiac mechanics between the enalapril and placebo groups. Core-lab echocardiogram measures prior to superior cavopulmonary connection (SCPC) and post-SCPC at 14 months of age were obtained. End-systolic elastance (Ees), a measure of contractility, and arterial elastance (Ea), a measure of afterload, were calculated. Ventriculo-arterial coupling was expressed as Ea/Ees. Data from 150 patients were analyzed. There was no difference in Ees, Ea, or Ea/Ees between study groups at either time point. The failure of enalapril to improve heart failure outcomes in this cohort may have some association with its failure to improve cardiac mechanics in single-ventricle physiology. Keywords: Enalapril, heart failure, pressure-volume loop analysis, single ventricle |
| Audience | Academic |
| Author | Graham, Eric M. Chowdhury, Shahryar M. Atz, Andrew M. Taylor, Carolyn L. Strelow, Jacob R. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40969967$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1152/ajpheart.00138.2005 10.1016/j.amjcard.2009.03.058 10.1161/CIRCULATIONAHA.109.927988 10.1016/j.echo.2016.02.016 10.1007/BF02696651 10.1152/ajpheart.00518.2019 10.1161/CIRCIMAGING.113.000722 |
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| References | Chowdhury (R5-20250901) 2016; 29 Yotti (R6-20250901) 2014; 7 Garcia (R7-20250901) 2020; 318 Burkhoff (R3-20250901) 2005; 289 Hsu (R1-20250901) 2010; 122 Margossian (R2-20250901) 2009; 104 Fox (R4-20250901) 2005; 2 |
| References_xml | – volume: 289 start-page: H501 year: 2005 ident: R3-20250901 article-title: Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: A guide for clinical, translational, and basic researchers publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00138.2005 – volume: 104 start-page: 419 year: 2009 ident: R2-20250901 article-title: Comparison of echocardiographic and cardiac magnetic resonance imaging measurements of functional single ventricular volumes, mass, and ejection fraction (from the Pediatric Heart Network Fontan Cross-Sectional Study) publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2009.03.058 – volume: 122 start-page: 333 year: 2010 ident: R1-20250901 article-title: Enalapril in infants with single ventricle: Results of a multicenter randomized trial publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.109.927988 – volume: 29 start-page: 640 year: 2016 ident: R5-20250901 article-title: Validation of noninvasive measures of left ventricular mechanics in children: A simultaneous echocardiographic and conductance catheterization study publication-title: J Am Soc Echocardiogr doi: 10.1016/j.echo.2016.02.016 – volume: 2 start-page: 204 year: 2005 ident: R4-20250901 article-title: Ventriculovascular coupling in systolic and diastolic heart failure publication-title: Curr Heart Fail Rep doi: 10.1007/BF02696651 – volume: 318 start-page: H947 year: 2020 ident: R7-20250901 article-title: Heart failure in single right ventricle congenital heart disease: Physiological and molecular considerations publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00518.2019 – volume: 7 start-page: 164 year: 2014 ident: R6-20250901 article-title: Validation of noninvasive indices of global systolic function in patients with normal and abnormal loading conditions: A simultaneous echocardiography pressure-volume catheterization study publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.113.000722 |
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| Title | The effect of enalapril on cardiac mechanics in the pediatric heart network infant single-ventricle trial: Insights using noninvasive pressure-volume loop analysis |
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