The effect of enalapril on cardiac mechanics in the pediatric heart network infant single-ventricle trial: Insights using noninvasive pressure-volume loop analysis

Patients with single-ventricle physiology who received enalapril in the Pediatric Heart Network Infant Single-ventricle Trial displayed no differences in heart failure outcomes compared to those who received a placebo. The objective of this study was to use noninvasive pressure-volume loop analysis...

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Veröffentlicht in:Annals of pediatric cardiology Jg. 18; H. 2; S. 142 - 144
Hauptverfasser: Strelow, Jacob R., Graham, Eric M., Taylor, Carolyn L., Atz, Andrew M., Chowdhury, Shahryar M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: India Wolters Kluwer - Medknow 01.03.2025
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Ausgabe:2
Schlagworte:
BRIEF COMMUNICATION
enalapril
Heart
heart failure
Pediatric cardiology
Physiological aspects
pressure-volume loop analysis
single ventricle
heart failure
Enalapril
single ventricle
pressure-volume loop analysis
ISSN:0974-2069, 0974-5149
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Zusammenfassung:Patients with single-ventricle physiology who received enalapril in the Pediatric Heart Network Infant Single-ventricle Trial displayed no differences in heart failure outcomes compared to those who received a placebo. The objective of this study was to use noninvasive pressure-volume loop analysis to assess for differences in cardiac mechanics between the enalapril and placebo groups. Core-lab echocardiogram measures prior to superior cavopulmonary connection (SCPC) and post-SCPC at 14 months of age were obtained. End-systolic elastance (Ees), a measure of contractility, and arterial elastance (Ea), a measure of afterload, were calculated. Ventriculo-arterial coupling was expressed as Ea/Ees. Data from 150 patients were analyzed. There was no difference in Ees, Ea, or Ea/Ees between study groups at either time point. The failure of enalapril to improve heart failure outcomes in this cohort may have some association with its failure to improve cardiac mechanics in single-ventricle physiology.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0974-2069
0974-5149
DOI:10.4103/apc.apc_67_25