The consequences of pain in early life: injury-induced plasticity in developing pain pathways

Pain in infancy influences pain reactivity in later life, but how and why this occurs is poorly understood. Here we review the evidence for developmental plasticity of nociceptive pathways in animal models and discuss the peripheral and central mechanisms that underlie this plasticity. Adults who ha...

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Vydáno v:	The European journal of neuroscience Ročník 39; číslo 3; s. 344 - 352
Hlavní autoři:	Schwaller, Fred, Fitzgerald, Maria
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	France Blackwell Publishing Ltd 01.02.2014 BlackWell Publishing Ltd
Témata:	Animal models Animals cannabinoids descending pain control Endocannabinoids - metabolism experience dependent-plasticity Humans hyperalgesia Hyperalgesia - metabolism Hyperalgesia - physiopathology Nervous System - growth & development Nervous System - metabolism Nervous System - physiopathology Neuralgia - metabolism Neuralgia - physiopathology Neuronal Plasticity newborn infant Special Issue: Neurobiology of Pain Trauma, Nervous System - metabolism Trauma, Nervous System - physiopathology experience dependent-plasticity cannabinoids hyperalgesia descending pain control newborn infant
ISSN:	0953-816X, 1460-9568, 1460-9568
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Shrnutí:	Pain in infancy influences pain reactivity in later life, but how and why this occurs is poorly understood. Here we review the evidence for developmental plasticity of nociceptive pathways in animal models and discuss the peripheral and central mechanisms that underlie this plasticity. Adults who have experienced neonatal injury display increased pain and injury‐induced hyperalgesia in the affected region but mild injury can also induce widespread baseline hyposensitivity across the rest of the body surface, suggesting the involvement of several underlying mechanisms, depending upon the type of early life experience. Peripheral nerve sprouting and dorsal horn central sensitization, disinhibition and neuroimmune priming are discussed in relation to the increased pain and hyperalgesia, while altered descending pain control systems driven, in part, by changes in the stress/HPA axis are discussed in relation to the widespread hypoalgesia. Finally, it is proposed that the endocannabinoid system deserves further attention in the search for mechanisms underlying injury‐induced changes in pain processing in infants and children. Pain in infancy influences pain reactivity in later life, but how and why this occurs is poorly understood. Here we review the evidence for developmental plasticity of nociceptive pathways in animal models and discuss the peripheral and central mechanisms that underlie this plasticity.
Bibliografie:	istex:941DC0F6B03464C902DF9986780C71F64385D5B4 ark:/67375/WNG-R507GML6-1 ArticleID:EJN12414 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0953-816X 1460-9568 1460-9568
DOI:	10.1111/ejn.12414