Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype

Endothelial dysfunction is a characteristic feature of diabetes and obesity in animal models and humans. Deficits in nitric oxide production by endothelial nitric oxide synthase (eNOS) are associated with insulin resistance, which is exacerbated by high-fat diet. Nevertheless, the metabolic effects...

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Vydané v:	Circulation research Ročník 111; číslo 9; s. 1176
Hlavní autori:	Sansbury, Brian E, Cummins, Timothy D, Tang, Yunan, Hellmann, Jason, Holden, Candice R, Harbeson, Matthew A, Chen, Yang, Patel, Rakesh P, Spite, Matthew, Bhatnagar, Aruni, Hill, Bradford G
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 12.10.2012
Predmet:	Adipocytes - pathology Amino Acids - metabolism Animals Diet, High-Fat - adverse effects Disease Models, Animal Hypertrophy Insulin Resistance - physiology Lipid Metabolism - physiology Mice Mice, Inbred C57BL Mice, Transgenic Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Obesity - etiology Obesity - physiopathology Obesity - prevention & control Phenotype PPAR alpha - metabolism PPAR gamma - metabolism
ISSN:	1524-4571, 1524-4571
On-line prístup:	Zistit podrobnosti o prístupe
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