Vascular Inward Rectifier K+ Channels as External K+ Sensors in the Control of Cerebral Blood Flow

For decades it has been known that external K+ ions are rapid and potent vasodilators that increase CBF. Recent studies have implicated the local release of K+ from astrocytic endfeet—which encase the entirety of the parenchymal vasculature—in the dynamic regulation of local CBF during NVC. It has b...

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Bibliographic Details
Published in:	Microcirculation (New York, N.Y. 1994) Vol. 22; no. 3; pp. 183 - 196
Main Authors:	Longden, Thomas A., Nelson, Mark T.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01.04.2015 Wiley Subscription Services, Inc
Subjects:	Animals astrocytic endfoot Blood Blood Flow Velocity - physiology capillary cerebral blood flow endothelium Endothelium, Vascular - metabolism functional hyperemia Humans inward rectifier potassium channel Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - metabolism neurovascular coupling Neurovascular Coupling - physiology parenchymal arteriole Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Signal Transduction - physiology smooth muscle Vasodilation - physiology endothelium capillary neurovascular coupling smooth muscle cerebral blood flow functional hyperemia parenchymal arteriole astrocytic endfoot inward rectifier potassium channel
ISSN:	1073-9688, 1549-8719, 1549-8719
Online Access:	Get full text
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