SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review

Sodium–glucose cotransporter (SGLT)2 inhibitors have been demonstrated to reduce cardiovascular events, particularly heart failure, in cardiovascular outcome trials. Here, we review the proposed mechanistic underpinnings of this benefit. Specifically, we focus on the role of SGLT2 inhibitors in opti...

Full description

Saved in:

Bibliographic Details
Published in:	Diabetologia Vol. 61; no. 10; pp. 2108 - 2117
Main Authors:	Verma, Subodh, McMurray, John J. V.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2018 Springer Nature B.V
Subjects:	Adipokines - metabolism Animals Benzhydryl Compounds - pharmacology Blood Glucose - metabolism Cardiovascular Diseases - complications Cardiovascular Diseases - drug therapy Diabetes Complications - complications Diabetes Complications - drug therapy Diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diuresis Glucosides - pharmacology Heart - drug effects Heart diseases Heart failure Heart Ventricles - drug effects Heart Ventricles - pathology Human Physiology Humans Hypoglycemic Agents - pharmacology Internal Medicine Kidney - drug effects Medicine Medicine & Public Health Metabolic Diseases Na+/glucose cotransporter Na+/H+-exchanging ATPase Review Sodium Sodium-Glucose Transporter 2 Inhibitors - pharmacology Structure-function relationships Ventricle Heart failure Mechanisms Review Cardiovascular effects SGLT2 inhibitors
ISSN:	0012-186X, 1432-0428, 1432-0428
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Sodium–glucose cotransporter (SGLT)2 inhibitors have been demonstrated to reduce cardiovascular events, particularly heart failure, in cardiovascular outcome trials. Here, we review the proposed mechanistic underpinnings of this benefit. Specifically, we focus on the role of SGLT2 inhibitors in optimising ventricular loading conditions through their effect on diuresis and natriuresis, in addition to reducing afterload and improving vascular structure and function. Further insights into the role of SGLT2 inhibition in myocardial metabolism and substrate utilisation are outlined. Finally, we discuss two emerging themes: how SGLT2 inhibitors may regulate Na + /H + exchange at the level of the heart and kidney and how they may modulate adipokine production. The mechanistic discussion is placed in the context of completed and ongoing trials of SGLT2 inhibitors in the prevention and treatment of heart failure in individuals with and without diabetes.
AbstractList	Sodium-glucose cotransporter (SGLT)2 inhibitors have been demonstrated to reduce cardiovascular events, particularly heart failure, in cardiovascular outcome trials. Here, we review the proposed mechanistic underpinnings of this benefit. Specifically, we focus on the role of SGLT2 inhibitors in optimising ventricular loading conditions through their effect on diuresis and natriuresis, in addition to reducing afterload and improving vascular structure and function. Further insights into the role of SGLT2 inhibition in myocardial metabolism and substrate utilisation are outlined. Finally, we discuss two emerging themes: how SGLT2 inhibitors may regulate Na /H exchange at the level of the heart and kidney and how they may modulate adipokine production. The mechanistic discussion is placed in the context of completed and ongoing trials of SGLT2 inhibitors in the prevention and treatment of heart failure in individuals with and without diabetes. Sodium–glucose cotransporter (SGLT)2 inhibitors have been demonstrated to reduce cardiovascular events, particularly heart failure, in cardiovascular outcome trials. Here, we review the proposed mechanistic underpinnings of this benefit. Specifically, we focus on the role of SGLT2 inhibitors in optimising ventricular loading conditions through their effect on diuresis and natriuresis, in addition to reducing afterload and improving vascular structure and function. Further insights into the role of SGLT2 inhibition in myocardial metabolism and substrate utilisation are outlined. Finally, we discuss two emerging themes: how SGLT2 inhibitors may regulate Na+/H+ exchange at the level of the heart and kidney and how they may modulate adipokine production. The mechanistic discussion is placed in the context of completed and ongoing trials of SGLT2 inhibitors in the prevention and treatment of heart failure in individuals with and without diabetes. Sodium-glucose cotransporter (SGLT)2 inhibitors have been demonstrated to reduce cardiovascular events, particularly heart failure, in cardiovascular outcome trials. Here, we review the proposed mechanistic underpinnings of this benefit. Specifically, we focus on the role of SGLT2 inhibitors in optimising ventricular loading conditions through their effect on diuresis and natriuresis, in addition to reducing afterload and improving vascular structure and function. Further insights into the role of SGLT2 inhibition in myocardial metabolism and substrate utilisation are outlined. Finally, we discuss two emerging themes: how SGLT2 inhibitors may regulate Na+/H+ exchange at the level of the heart and kidney and how they may modulate adipokine production. The mechanistic discussion is placed in the context of completed and ongoing trials of SGLT2 inhibitors in the prevention and treatment of heart failure in individuals with and without diabetes.Sodium-glucose cotransporter (SGLT)2 inhibitors have been demonstrated to reduce cardiovascular events, particularly heart failure, in cardiovascular outcome trials. Here, we review the proposed mechanistic underpinnings of this benefit. Specifically, we focus on the role of SGLT2 inhibitors in optimising ventricular loading conditions through their effect on diuresis and natriuresis, in addition to reducing afterload and improving vascular structure and function. Further insights into the role of SGLT2 inhibition in myocardial metabolism and substrate utilisation are outlined. Finally, we discuss two emerging themes: how SGLT2 inhibitors may regulate Na+/H+ exchange at the level of the heart and kidney and how they may modulate adipokine production. The mechanistic discussion is placed in the context of completed and ongoing trials of SGLT2 inhibitors in the prevention and treatment of heart failure in individuals with and without diabetes. Sodium–glucose cotransporter (SGLT)2 inhibitors have been demonstrated to reduce cardiovascular events, particularly heart failure, in cardiovascular outcome trials. Here, we review the proposed mechanistic underpinnings of this benefit. Specifically, we focus on the role of SGLT2 inhibitors in optimising ventricular loading conditions through their effect on diuresis and natriuresis, in addition to reducing afterload and improving vascular structure and function. Further insights into the role of SGLT2 inhibition in myocardial metabolism and substrate utilisation are outlined. Finally, we discuss two emerging themes: how SGLT2 inhibitors may regulate Na + /H + exchange at the level of the heart and kidney and how they may modulate adipokine production. The mechanistic discussion is placed in the context of completed and ongoing trials of SGLT2 inhibitors in the prevention and treatment of heart failure in individuals with and without diabetes.
Author	Verma, Subodh McMurray, John J. V.
Author_xml	– sequence: 1 givenname: Subodh surname: Verma fullname: Verma, Subodh email: vermasu@smh.ca organization: Division of Cardiac Surgery, Li Ka Shing Knowledge Institute of St Michael’s Hospital, University of Toronto – sequence: 2 givenname: John J. V. surname: McMurray fullname: McMurray, John J. V. organization: British Heart Foundation, Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30132036$$D View this record in MEDLINE/PubMed
BookMark	eNp9kUFrFTEQx4NU7Gv1A3iRgBcv0Umy2ezzJqXWwgMPPsFbyGYnvpTdpCbZFr-9u7yqUNDTHOb3mxnmf0ZOYopIyEsObzmAflcAuFAMeMeaVgPTT8iGN1IwaER3QjZrm_Gu_XZKzkq5AQCpmvYZOZXApQDZbsj-y9VuL2iIh9CHmnKhNg50QnewMZSp0OSps3kI6c4WN4820x4j-lDfU0tLtRVZ8qwekNlcaca7gPfPyVNvx4IvHuo5-frxcn_xie0-X11ffNgxpxSvzDf91nqtOChuW6G0VHzopfNOteg9oNReboX3g9CuE0r0Vqihw5aj44Po5Dl5c5x7m9OPGUs1UygOx9FGTHMxAra8ExykXNDXj9CbNOe4XLdSsBVSdyv16oGa-wkHc5vDZPNP8_tfC8CPgMuplIz-D8LBrJmYYyZmycSsmRi9OPqR48Lyt5BizTaM_zXF0SzLlvgd89-j_y39Avt6nio
CitedBy_id	crossref_primary_10_3389_fphar_2023_1175606 crossref_primary_10_1177_2047487319880040 crossref_primary_10_3390_jcm11040977 crossref_primary_10_1016_j_jacc_2020_10_005 crossref_primary_10_1177_2047487319901063 crossref_primary_10_1210_clinem_dgab834 crossref_primary_10_1016_j_amjmed_2019_08_007 crossref_primary_10_3390_jpm12020271 crossref_primary_10_1016_j_ccl_2024_12_010 crossref_primary_10_1016_j_amjmed_2020_04_006 crossref_primary_10_1186_s12933_020_01042_3 crossref_primary_10_1016_j_rccar_2019_12_003 crossref_primary_10_1016_j_rccar_2019_12_004 crossref_primary_10_1001_jamanetworkopen_2022_7705 crossref_primary_10_3390_jcm13237093 crossref_primary_10_1016_j_jdiacomp_2020_107811 crossref_primary_10_1016_j_diabet_2019_01_008 crossref_primary_10_1007_s10741_020_10024_2 crossref_primary_10_1016_j_bcp_2020_114009 crossref_primary_10_3389_fphar_2021_751214 crossref_primary_10_3389_fcvm_2022_1064196 crossref_primary_10_1016_j_hrthm_2021_03_028 crossref_primary_10_2337_db24_0406 crossref_primary_10_1016_j_ijcard_2021_12_050 crossref_primary_10_1161_HYPERTENSIONAHA_120_16466 crossref_primary_10_1186_s12872_024_04454_1 crossref_primary_10_1186_s40001_025_02834_7 crossref_primary_10_1016_j_ahj_2022_12_005 crossref_primary_10_1016_j_jdiacomp_2025_109021 crossref_primary_10_1093_eurheartj_ehad389 crossref_primary_10_1186_s12933_025_02745_1 crossref_primary_10_1001_jamanetworkopen_2019_16447 crossref_primary_10_2147_JEP_S522053 crossref_primary_10_36660_ijcs_20200339 crossref_primary_10_3389_fcvm_2022_1011429 crossref_primary_10_3390_ijms26104780 crossref_primary_10_1186_s12872_021_02250_9 crossref_primary_10_1146_annurev_physiol_031620_095920 crossref_primary_10_3390_ph18081202 crossref_primary_10_1007_s00392_022_02049_4 crossref_primary_10_1016_j_tcm_2022_05_005 crossref_primary_10_1007_s13300_022_01219_x crossref_primary_10_1016_j_drudis_2025_104451 crossref_primary_10_1016_j_jacc_2020_11_029 crossref_primary_10_23876_j_krcp_23_156 crossref_primary_10_1186_s13098_024_01553_z crossref_primary_10_1056_NEJMe1912180 crossref_primary_10_1016_j_hfc_2022_03_004 crossref_primary_10_1007_s11897_021_00529_8 crossref_primary_10_3390_jcm11113192 crossref_primary_10_1016_j_hfc_2022_03_009 crossref_primary_10_1111_dom_15183 crossref_primary_10_1016_j_ijcard_2020_08_017 crossref_primary_10_3390_ijms20246345 crossref_primary_10_2337_dbi21_0025 crossref_primary_10_3389_fphar_2022_827033 crossref_primary_10_1002_phar_2839 crossref_primary_10_1080_17512433_2022_2051480 crossref_primary_10_1093_ajhp_zxaa243 crossref_primary_10_1161_CIRCULATIONAHA_119_042375 crossref_primary_10_1186_s13098_023_01196_6 crossref_primary_10_3390_life12060803 crossref_primary_10_1007_s00059_020_04946_8 crossref_primary_10_1038_s41392_022_01080_1 crossref_primary_10_1080_14656566_2021_1939679 crossref_primary_10_1097_MED_0000000000000896 crossref_primary_10_1186_s12933_024_02466_x crossref_primary_10_1001_jama_2020_1905 crossref_primary_10_1002_pdi_2329 crossref_primary_10_1016_j_bcp_2021_114674 crossref_primary_10_17925_HI_2023_17_2_2 crossref_primary_10_1001_jama_2020_1906 crossref_primary_10_1016_j_ijcard_2022_06_059 crossref_primary_10_1016_j_jacc_2021_12_012 crossref_primary_10_3389_fendo_2020_599355 crossref_primary_10_1016_j_cardfail_2021_04_023 crossref_primary_10_1177_2633559X211034488 crossref_primary_10_1177_00033197211047329 crossref_primary_10_3389_fendo_2021_622901 crossref_primary_10_1016_j_hipert_2019_03_005 crossref_primary_10_1186_s12933_019_0910_5 crossref_primary_10_1016_j_diabres_2022_110141 crossref_primary_10_14797_mdcvj_1120 crossref_primary_10_1097_HCO_0000000000000673 crossref_primary_10_1111_jcpt_13107 crossref_primary_10_1002_ejhf_2286 crossref_primary_10_3390_jpm14020141 crossref_primary_10_1007_s15006_019_0511_y crossref_primary_10_1016_j_diabres_2025_112050 crossref_primary_10_1016_j_ejphar_2022_175194 crossref_primary_10_3390_pharmacy11020058 crossref_primary_10_7759_cureus_63796 crossref_primary_10_1002_edm2_183 crossref_primary_10_1016_j_hrthm_2025_09_023 crossref_primary_10_4330_wjc_v17_i1_101491 crossref_primary_10_1186_s12933_021_01213_w crossref_primary_10_1080_14728222_2023_2218616 crossref_primary_10_3390_biom12101349 crossref_primary_10_1210_endocr_bqab157 crossref_primary_10_1097_HJH_0000000000004007 crossref_primary_10_1016_j_ihj_2021_07_005 crossref_primary_10_3390_jcm14155246 crossref_primary_10_3390_healthcare10071153 crossref_primary_10_1155_2022_6103086 crossref_primary_10_1186_s12933_020_01011_w crossref_primary_10_1186_s13098_023_01129_3 crossref_primary_10_1186_s40959_023_00199_6 crossref_primary_10_7759_cureus_31777 crossref_primary_10_7759_cureus_31898 crossref_primary_10_3390_ijms24097789 crossref_primary_10_1016_j_jjcc_2024_09_005 crossref_primary_10_1136_dtb_2024_000050 crossref_primary_10_1007_s40200_021_00874_4 crossref_primary_10_1093_ajh_hpz157 crossref_primary_10_1161_CIRCULATIONAHA_120_052503 crossref_primary_10_1097_HCO_0000000000000774 crossref_primary_10_1161_CIRCULATIONAHA_120_050686 crossref_primary_10_15829_1560_4071_2021_4807 crossref_primary_10_1177_1358863X221101653 crossref_primary_10_3389_fcvm_2021_716083 crossref_primary_10_1007_s11096_025_01908_0 crossref_primary_10_2337_db20_0921 crossref_primary_10_36740_EmeMS202003109 crossref_primary_10_1007_s00795_022_00334_9 crossref_primary_10_1007_s10741_022_10256_4 crossref_primary_10_1093_ejendo_lvad078 crossref_primary_10_1038_s41598_020_70708_5 crossref_primary_10_1161_CIRCULATIONAHA_119_044235 crossref_primary_10_3390_molecules27217174 crossref_primary_10_1007_s11906_022_01166_9 crossref_primary_10_1097_HCO_0000000000000647 crossref_primary_10_1016_j_ejphar_2021_174715 crossref_primary_10_3390_ijms25147711 crossref_primary_10_1016_j_hjc_2023_12_002 crossref_primary_10_1007_s13300_019_00686_z crossref_primary_10_1016_j_bcp_2024_116232 crossref_primary_10_1016_j_tips_2025_02_005 crossref_primary_10_1038_s41569_023_00877_z crossref_primary_10_3390_metabo11020087 crossref_primary_10_3389_fendo_2023_1147752 crossref_primary_10_1007_s40119_020_00208_0 crossref_primary_10_2147_DMSO_S330606 crossref_primary_10_1053_j_ajkd_2020_08_003 crossref_primary_10_1111_jce_16369 crossref_primary_10_1161_CIRCULATIONAHA_118_039177 crossref_primary_10_1007_s11883_022_01038_2 crossref_primary_10_1161_CIRCHEARTFAILURE_119_006277 crossref_primary_10_1161_CIRCULATIONAHA_120_052446 crossref_primary_10_1111_dom_13629 crossref_primary_10_1007_s11255_022_03211_7 crossref_primary_10_1007_s00125_020_05359_2 crossref_primary_10_1007_s40261_021_01095_6 crossref_primary_10_1007_s40265_019_01148_3 crossref_primary_10_1002_ehf2_14335 crossref_primary_10_7759_cureus_25476 crossref_primary_10_1017_S0266462321001689 crossref_primary_10_3390_nu16234204 crossref_primary_10_1002_jcph_1987 crossref_primary_10_1016_j_jjcc_2025_05_004 crossref_primary_10_3803_EnM_2024_2223 crossref_primary_10_15829_1560_4071_2021_4534 crossref_primary_10_1002_edm2_129 crossref_primary_10_3389_fphar_2021_798381 crossref_primary_10_1097_FJC_0000000000001011 crossref_primary_10_3390_ijms24044144 crossref_primary_10_1007_s40265_021_01565_3 crossref_primary_10_1186_s12933_020_01105_5 crossref_primary_10_1007_s40256_020_00441_x crossref_primary_10_1210_clinem_dgac197 crossref_primary_10_1016_S0140_6736_21_00519_5 crossref_primary_10_1002_ehf2_14224 crossref_primary_10_1016_j_ccl_2021_12_003 crossref_primary_10_1002_cmdc_202500259 crossref_primary_10_1080_17446651_2023_2210673 crossref_primary_10_1161_CIRCULATIONAHA_122_060402 crossref_primary_10_1002_mco2_283 crossref_primary_10_1007_s00592_023_02154_4 crossref_primary_10_1002_cbf_3922 crossref_primary_10_1016_S2213_8587_18_30311_5 crossref_primary_10_1016_j_rmed_2024_107631 crossref_primary_10_1038_s41392_024_01931_z crossref_primary_10_1016_j_cmet_2019_04_011 crossref_primary_10_1007_s10741_021_10157_y crossref_primary_10_1007_s13300_021_01004_2 crossref_primary_10_1111_dom_14818 crossref_primary_10_1111_liv_15851 crossref_primary_10_1002_ejhf_2220 crossref_primary_10_1186_s12576_024_00938_z crossref_primary_10_1186_s12933_019_0852_y crossref_primary_10_36660_abchf_20220003 crossref_primary_10_1016_j_cmet_2018_11_010 crossref_primary_10_1161_CIRCRESAHA_120_315913 crossref_primary_10_1186_s12933_020_01048_x crossref_primary_10_1161_JAHA_120_020418 crossref_primary_10_1002_ehf2_14434 crossref_primary_10_1155_2021_9927533 crossref_primary_10_1016_j_ejmech_2019_07_032 crossref_primary_10_1016_j_jacc_2020_05_037 crossref_primary_10_1038_s41371_018_0134_2 crossref_primary_10_1111_pace_14621 crossref_primary_10_1186_s12576_023_00861_9 crossref_primary_10_1371_journal_pone_0269414 crossref_primary_10_1111_dom_13854 crossref_primary_10_1016_j_ejmcr_2022_100074 crossref_primary_10_1002_pdi_2281 crossref_primary_10_1016_j_pcad_2025_08_010 crossref_primary_10_3390_biomedicines11072085 crossref_primary_10_3390_biomedicines11041126 crossref_primary_10_1111_dom_13970 crossref_primary_10_1016_S2213_8587_24_00102_5 crossref_primary_10_1002_ehf2_13236 crossref_primary_10_1016_j_pcad_2019_07_005 crossref_primary_10_1080_14656566_2020_1776262 crossref_primary_10_1016_j_hfc_2019_08_012 crossref_primary_10_1093_eurheartj_ehab709 crossref_primary_10_1016_j_metabol_2022_155332 crossref_primary_10_1007_s13410_023_01287_0 crossref_primary_10_1016_j_bcp_2020_114276 crossref_primary_10_1007_s00228_019_02732_y crossref_primary_10_1007_s10557_022_07355_7 crossref_primary_10_1007_s13300_019_00680_5 crossref_primary_10_1016_j_jjcc_2024_02_002 crossref_primary_10_1016_j_jchf_2020_04_008 crossref_primary_10_7759_cureus_57380 crossref_primary_10_4330_wjc_v16_i11_665 crossref_primary_10_1007_s40266_024_01165_2 crossref_primary_10_1093_ehjcvp_pvaa051 crossref_primary_10_1016_j_envres_2025_122532 crossref_primary_10_1097_FJC_0000000000001689 crossref_primary_10_1016_j_cpcardiol_2025_103171 crossref_primary_10_3390_clinpract13060116 crossref_primary_10_1016_j_regg_2025_101686 crossref_primary_10_1097_JCMA_0000000000000276 crossref_primary_10_1080_17446651_2022_2099838 crossref_primary_10_3390_ijms23073651 crossref_primary_10_2459_JCM_0000000000001328 crossref_primary_10_1016_j_lanwpc_2024_101138 crossref_primary_10_1155_2021_6657380 crossref_primary_10_1007_s00392_023_02164_w crossref_primary_10_3390_ijms20030629 crossref_primary_10_1111_dom_13678 crossref_primary_10_3389_fmed_2025_1574693 crossref_primary_10_3390_jcm14186365 crossref_primary_10_1371_journal_pone_0277321 crossref_primary_10_1002_clc_24158 crossref_primary_10_1016_j_ejmech_2024_116343 crossref_primary_10_1016_j_molmed_2019_03_006 crossref_primary_10_3389_fcvm_2023_1005408 crossref_primary_10_1002_ehf2_13171 crossref_primary_10_3390_medicina58081128 crossref_primary_10_1016_j_rccar_2020_07_005 crossref_primary_10_1007_s00592_024_02303_3 crossref_primary_10_1111_dom_14858 crossref_primary_10_31083_j_fbl2804083 crossref_primary_10_3390_biom11101426 crossref_primary_10_4239_wjd_v11_i7_269 crossref_primary_10_1016_j_metabol_2019_04_008 crossref_primary_10_3390_jcm10030505 crossref_primary_10_7759_cureus_40602 crossref_primary_10_1097_FJC_0000000000001581 crossref_primary_10_3389_fphys_2022_1010578 crossref_primary_10_1186_s40360_024_00747_5 crossref_primary_10_3390_jcm11175027 crossref_primary_10_3389_fendo_2021_738848 crossref_primary_10_1080_17460441_2022_2047644 crossref_primary_10_3390_jcm14165894 crossref_primary_10_1002_ehf2_14357 crossref_primary_10_1002_ehf2_13024 crossref_primary_10_1007_s40256_023_00601_9 crossref_primary_10_1177_00368504251358106 crossref_primary_10_1016_j_nurpra_2021_02_008 crossref_primary_10_1186_s12933_023_01855_y crossref_primary_10_1016_j_ijcard_2021_01_063 crossref_primary_10_1007_s12325_019_01054_w crossref_primary_10_1007_s11886_019_1219_4 crossref_primary_10_1111_dom_14508 crossref_primary_10_37349_eemd_2025_101435 crossref_primary_10_1016_j_drudis_2021_04_007 crossref_primary_10_1111_1759_7714_15509 crossref_primary_10_1111_dom_14864 crossref_primary_10_1097_MD_0000000000036895 crossref_primary_10_3390_jcm10112501 crossref_primary_10_1001_jama_2020_10262 crossref_primary_10_1016_j_ejmech_2021_113633 crossref_primary_10_1093_ckj_sfae234 crossref_primary_10_1016_j_hrtlng_2023_02_009 crossref_primary_10_1038_s41467_024_54171_8 crossref_primary_10_1161_HYPERTENSIONAHA_119_11684 crossref_primary_10_7759_cureus_60877 crossref_primary_10_1186_s12933_019_0894_1 crossref_primary_10_3389_fcvm_2022_1086672 crossref_primary_10_3390_biomedicines10071656 crossref_primary_10_2147_TCRM_S275076 crossref_primary_10_1016_S1878_6480_19_30961_9 crossref_primary_10_1177_1060028020985111 crossref_primary_10_3390_ijerph16162965 crossref_primary_10_1038_s41598_021_93156_1 crossref_primary_10_3390_jcdd10070287 crossref_primary_10_1016_j_jacc_2019_11_031 crossref_primary_10_1002_ehf2_13645 crossref_primary_10_2147_JMDH_S494004 crossref_primary_10_1016_S2213_8587_19_30311_0 crossref_primary_10_1002_ejhf_1432 crossref_primary_10_1002_ehf2_12555 crossref_primary_10_1016_S0140_6736_18_32824_1 crossref_primary_10_2174_0929867326666191029111713 crossref_primary_10_1016_S0140_6736_19_31267_X crossref_primary_10_3390_jcm11237214 crossref_primary_10_4103_ijp_ijp_924_24 crossref_primary_10_15829_1560_4071_2021_4279 crossref_primary_10_1093_clinchem_hvaa277 crossref_primary_10_1016_j_xkme_2022_100446 crossref_primary_10_3390_jcm10122713 crossref_primary_10_2459_JCM_0000000000001523 crossref_primary_10_1007_s13300_020_00921_y crossref_primary_10_3390_ijms20153737 crossref_primary_10_7759_cureus_33484 crossref_primary_10_3389_fcvm_2022_882089 crossref_primary_10_1097_JCMA_0000000000000359 crossref_primary_10_3390_ijms24098283 crossref_primary_10_1093_eurheartjsupp_suae008 crossref_primary_10_3389_fphys_2021_738594 crossref_primary_10_1007_s13300_023_01491_5 crossref_primary_10_1111_jdi_13329 crossref_primary_10_1093_cvr_cvab075 crossref_primary_10_1186_s12576_023_00877_1 crossref_primary_10_1186_s12933_024_02557_9 crossref_primary_10_2337_dc20_0456 crossref_primary_10_1111_dom_14203 crossref_primary_10_3390_ijms25116218 crossref_primary_10_1111_dme_14140 crossref_primary_10_2337_dc20_2518 crossref_primary_10_1016_j_jacc_2023_05_048 crossref_primary_10_1093_ejcts_ezae221 crossref_primary_10_1002_ejhf_1548 crossref_primary_10_1111_dom_70012 crossref_primary_10_1186_s12933_023_01849_w crossref_primary_10_1007_s40620_020_00845_7 crossref_primary_10_1016_j_hfc_2019_06_008 crossref_primary_10_1161_CIRCULATIONAHA_119_039996 crossref_primary_10_1093_cvr_cvae016 crossref_primary_10_1111_1753_0407_13209 crossref_primary_10_3390_ijms22115973 crossref_primary_10_1161_CIR_0000000000001063 crossref_primary_10_3390_antiox9020140 crossref_primary_10_3389_fmed_2021_695792 crossref_primary_10_3390_jcm13123522 crossref_primary_10_1007_s00044_024_03274_4 crossref_primary_10_3390_jcm11020348 crossref_primary_10_3390_medicina61020202 crossref_primary_10_3390_biomedicines13030608 crossref_primary_10_4239_wjd_v12_i7_932 crossref_primary_10_1161_CIRCULATIONAHA_119_042929 crossref_primary_10_4254_wjh_v13_i3_300 crossref_primary_10_1111_jdi_13481 crossref_primary_10_3390_biomedicines10102458 crossref_primary_10_1186_s12933_020_01169_3 crossref_primary_10_15829_1560_4071_2019_11_98_111 crossref_primary_10_1016_j_pcad_2020_04_011 crossref_primary_10_2459_JCM_0000000000001426 crossref_primary_10_2459_JCM_0000000000001547 crossref_primary_10_1016_j_ajpc_2024_100927 crossref_primary_10_1016_j_biopha_2023_115686 crossref_primary_10_1042_BSR20240604 crossref_primary_10_2217_fca_2020_0178 crossref_primary_10_1016_j_amjcard_2019_10_028 crossref_primary_10_1016_j_rec_2019_07_009 crossref_primary_10_1080_14656566_2024_2408376 crossref_primary_10_1186_s12933_024_02481_y crossref_primary_10_1016_j_diabres_2025_112320 crossref_primary_10_2337_dbi20_0040 crossref_primary_10_1093_ehjcvp_pvac043 crossref_primary_10_1177_26324636251356433 crossref_primary_10_1002_clc_70190 crossref_primary_10_7759_cureus_69229 crossref_primary_10_1186_s12933_020_01071_y crossref_primary_10_3390_nu13010257 crossref_primary_10_1002_ehf2_13871 crossref_primary_10_1016_j_jacasi_2022_03_009 crossref_primary_10_1080_17425255_2022_2147425 crossref_primary_10_3390_genes12081174 crossref_primary_10_1016_j_jacasi_2021_08_003 crossref_primary_10_1161_CIRCULATIONAHA_119_040514 crossref_primary_10_1186_s12933_025_02708_6 crossref_primary_10_1161_CIRCULATIONAHA_122_062769 crossref_primary_10_1016_j_kint_2021_01_008 crossref_primary_10_1016_j_repc_2021_02_010 crossref_primary_10_15829_1728_8800_2021_2648 crossref_primary_10_1016_j_metabol_2019_154045 crossref_primary_10_35339_msz_2025_94_2_dun crossref_primary_10_1016_j_jcmg_2020_10_017 crossref_primary_10_1007_s00392_022_02119_7 crossref_primary_10_1007_s13300_022_01276_2 crossref_primary_10_15829_1560_4071_2020_3766 crossref_primary_10_1016_j_clinthera_2025_04_019 crossref_primary_10_1111_dom_14596 crossref_primary_10_1210_clinem_dgae861 crossref_primary_10_1111_dom_14352 crossref_primary_10_1016_j_jjcc_2022_02_008 crossref_primary_10_2337_dc20_2604 crossref_primary_10_1111_imj_15993 crossref_primary_10_1007_s13300_020_00889_9 crossref_primary_10_1097_CRD_0000000000000635 crossref_primary_10_3390_jcm12010379 crossref_primary_10_1007_s11886_019_1165_1 crossref_primary_10_1136_bmj_2023_078242 crossref_primary_10_1007_s10787_021_00818_7 crossref_primary_10_1080_14656566_2020_1850694 crossref_primary_10_3390_metabo12020183 crossref_primary_10_1038_s41440_021_00799_8 crossref_primary_10_2217_fca_2019_0065 crossref_primary_10_3390_jcm12185898 crossref_primary_10_1186_s40001_024_01954_w crossref_primary_10_1111_ijd_16449 crossref_primary_10_1016_j_jval_2025_01_015 crossref_primary_10_1007_s11886_021_01486_3 crossref_primary_10_3390_biomedicines13061474 crossref_primary_10_1007_s00125_021_05442_2 crossref_primary_10_1016_j_ejca_2024_115170 crossref_primary_10_1111_eci_13748 crossref_primary_10_1016_j_jaccao_2024_08_001 crossref_primary_10_1016_j_ejphar_2023_175626 crossref_primary_10_1093_cvr_cvab271 crossref_primary_10_1111_eci_13624 crossref_primary_10_1016_j_ejmech_2024_116185 crossref_primary_10_3390_ijms232314598 crossref_primary_10_1111_dom_14363 crossref_primary_10_1093_ehjcvp_pvad033 crossref_primary_10_1111_dom_15335 crossref_primary_10_1186_s12933_019_0919_9 crossref_primary_10_1007_s13410_024_01380_y crossref_primary_10_1007_s10557_021_07190_2 crossref_primary_10_1016_j_semnephrol_2021_06_007 crossref_primary_10_1016_j_diabres_2022_109837 crossref_primary_10_1016_j_jdiacomp_2020_107588 crossref_primary_10_1016_j_xkme_2023_100705 crossref_primary_10_1161_JAHA_121_022222 crossref_primary_10_1016_j_ejps_2023_106415 crossref_primary_10_3389_fpubh_2022_936703 crossref_primary_10_3390_pharmacy10060166 crossref_primary_10_1016_j_biopha_2021_111649 crossref_primary_10_1056_NEJMoa1911303 crossref_primary_10_1161_JAHA_118_010033 crossref_primary_10_2478_fzm_2022_0030 crossref_primary_10_1016_j_pdpdt_2023_103804 crossref_primary_10_1177_1358863X221143811 crossref_primary_10_1210_jendso_bvae106 crossref_primary_10_2147_CIA_S297494 crossref_primary_10_1007_s11154_020_09558_5 crossref_primary_10_3390_jcm13030777 crossref_primary_10_1053_j_jvca_2025_06_015 crossref_primary_10_3390_ijms24076278 crossref_primary_10_1007_s00125_018_4673_4 crossref_primary_10_1007_s10741_021_10083_z crossref_primary_10_1186_s13098_023_01046_5 crossref_primary_10_1016_j_jjcc_2025_07_003 crossref_primary_10_1186_s13063_019_3474_5 crossref_primary_10_1016_j_repce_2021_02_006 crossref_primary_10_1016_j_diabres_2021_108796 crossref_primary_10_1097_CD9_0000000000000060 crossref_primary_10_1186_s12933_020_01060_1 crossref_primary_10_2478_jce_2021_0017 crossref_primary_10_3389_fped_2021_756593 crossref_primary_10_3389_fcvm_2025_1583702 crossref_primary_10_1093_eurjpc_zwae130 crossref_primary_10_3389_fendo_2022_1078686 crossref_primary_10_3390_endocrines4030045 crossref_primary_10_1016_j_jcjd_2019_08_012 crossref_primary_10_3390_jcm12010042 crossref_primary_10_1111_dom_70118 crossref_primary_10_1007_s40200_023_01305_2 crossref_primary_10_1093_eurheartj_ehaa419 crossref_primary_10_1097_MD_0000000000028636 crossref_primary_10_1186_s12872_025_05014_x crossref_primary_10_3390_children11070859 crossref_primary_10_1007_s15034_019_1493_7 crossref_primary_10_3389_fendo_2022_846903 crossref_primary_10_1007_s40256_024_00673_1 crossref_primary_10_1002_ejhf_1708 crossref_primary_10_1016_j_ejim_2021_11_008 crossref_primary_10_1161_JAHA_123_031805 crossref_primary_10_1007_s13300_021_01173_0 crossref_primary_10_1155_2021_5593589 crossref_primary_10_1007_s11845_024_03744_z crossref_primary_10_1007_s12020_019_01931_y crossref_primary_10_1016_j_jcte_2024_100341 crossref_primary_10_1097_XCE_0000000000000171 crossref_primary_10_3389_fendo_2023_1158153 crossref_primary_10_7759_cureus_90684 crossref_primary_10_3390_ijms23179559 crossref_primary_10_1007_s10557_020_06973_3 crossref_primary_10_1097_XCE_0000000000000178 crossref_primary_10_3390_antiox14020163 crossref_primary_10_1186_s13098_023_01081_2 crossref_primary_10_1007_s40262_020_00885_z crossref_primary_10_1111_dom_15483 crossref_primary_10_1002_ejhf_1954 crossref_primary_10_1002_ejhf_1713 crossref_primary_10_1016_S0140_6736_22_02164_X crossref_primary_10_3389_fphar_2023_1078205 crossref_primary_10_1007_s10741_020_09925_z crossref_primary_10_1177_20420188211034300 crossref_primary_10_1186_s12933_022_01540_6 crossref_primary_10_1161_CIRCULATIONAHA_120_048739 crossref_primary_10_1007_s11883_025_01333_8 crossref_primary_10_15829_1728_8800_2024_4090 crossref_primary_10_3390_audiolres15040102 crossref_primary_10_7759_cureus_91789 crossref_primary_10_1093_ckj_sfac203 crossref_primary_10_3389_fendo_2022_917761 crossref_primary_10_1016_j_jacadv_2025_101615 crossref_primary_10_1007_s13300_019_0657_8 crossref_primary_10_3389_fcvm_2022_992327 crossref_primary_10_1007_s40266_024_01098_w crossref_primary_10_3390_ijerph191911990 crossref_primary_10_3390_antiox10081166 crossref_primary_10_3390_diseases8020014 crossref_primary_10_1007_s11298_019_0001_7 crossref_primary_10_1007_s40119_021_00242_6 crossref_primary_10_1093_eurheartj_ehaa183 crossref_primary_10_1002_ehf2_12819 crossref_primary_10_1139_cjpp_2018_0359 crossref_primary_10_1002_ehf2_12937 crossref_primary_10_1016_j_pupt_2021_102035 crossref_primary_10_1111_dom_15586 crossref_primary_10_1111_dom_14017 crossref_primary_10_1136_heartjnl_2024_324847 crossref_primary_10_1007_s12325_023_02652_5 crossref_primary_10_1111_dom_14015 crossref_primary_10_1016_j_ijcard_2021_06_045 crossref_primary_10_1161_CIRCULATIONAHA_121_053350 crossref_primary_10_1017_S1047951125109335 crossref_primary_10_3390_medicina60020274 crossref_primary_10_1002_ejhf_1935 crossref_primary_10_1016_j_diabres_2019_107947 crossref_primary_10_1186_s12933_021_01295_6 crossref_primary_10_33590_emj_22_00026 crossref_primary_10_3390_ijms20235853 crossref_primary_10_38124_ijisrt_25jun1067 crossref_primary_10_1016_S2213_8587_21_00292_8 crossref_primary_10_1016_j_eprac_2025_02_014 crossref_primary_10_2196_56067 crossref_primary_10_1002_ehf2_12707 crossref_primary_10_1186_s12933_025_02678_9 crossref_primary_10_14814_phy2_70397 crossref_primary_10_1016_j_ando_2021_10_003 crossref_primary_10_1016_S1957_2557_19_30061_6 crossref_primary_10_1080_17425255_2019_1588886 crossref_primary_10_1016_j_bcp_2022_115263 crossref_primary_10_1111_dom_14386 crossref_primary_10_1186_s43044_021_00218_w crossref_primary_10_3390_ijms25158235 crossref_primary_10_1177_20420188211042145 crossref_primary_10_3389_fendo_2025_1487058 crossref_primary_10_3390_clinpract13050090 crossref_primary_10_1007_s10741_021_10170_1 crossref_primary_10_1007_s13300_020_00951_6 crossref_primary_10_1016_j_cardfail_2020_04_005 crossref_primary_10_1002_clc_23847 crossref_primary_10_3389_fcvm_2022_1041200 crossref_primary_10_1007_s15027_020_0415_x crossref_primary_10_1159_000504694 crossref_primary_10_1016_j_cjca_2019_11_036 crossref_primary_10_1016_j_diabres_2021_109033 crossref_primary_10_1053_j_ackd_2021_02_006 crossref_primary_10_1161_JAHA_119_012356 crossref_primary_10_3390_biomedicines12061314 crossref_primary_10_1016_j_ijbiomac_2024_130663 crossref_primary_10_1016_j_tcm_2019_11_011 crossref_primary_10_1080_14779072_2020_1756778 crossref_primary_10_1111_jch_14662 crossref_primary_10_1007_s11739_020_02297_0 crossref_primary_10_3390_life14010030 crossref_primary_10_1016_j_arr_2023_101884 crossref_primary_10_1080_17425255_2022_2105693 crossref_primary_10_1161_CIRCULATIONAHA_119_040921 crossref_primary_10_1016_j_bbrc_2023_149434 crossref_primary_10_1007_s40273_023_01286_3 crossref_primary_10_1016_j_jcjd_2019_09_003 crossref_primary_10_3390_jcm12082814 crossref_primary_10_1111_ajt_17035 crossref_primary_10_1007_s13353_019_00502_1 crossref_primary_10_1007_s10741_019_09849_3 crossref_primary_10_3389_fendo_2020_604250 crossref_primary_10_1038_s42003_023_04663_y crossref_primary_10_1186_s12933_021_01390_8 crossref_primary_10_1002_lim2_25 crossref_primary_10_1016_j_bbrc_2022_10_034 crossref_primary_10_3390_metabo13010087 crossref_primary_10_1016_j_bbalip_2020_158813 crossref_primary_10_1186_s12933_019_0916_z crossref_primary_10_1016_S1957_2557_19_30062_8 crossref_primary_10_15829_1560_4071_2025_6539 crossref_primary_10_1136_bmjdrc_2022_002801 crossref_primary_10_1016_j_prostaglandins_2020_106454 crossref_primary_10_1111_ijcp_14794 crossref_primary_10_1007_s11892_024_01572_0 crossref_primary_10_1016_j_jacep_2023_06_008 crossref_primary_10_1016_j_gie_2024_10_057 crossref_primary_10_1007_s00395_022_00934_7 crossref_primary_10_1038_s41581_022_00648_y crossref_primary_10_1186_s12933_020_01175_5 crossref_primary_10_1186_s12933_021_01380_w crossref_primary_10_34067_KID_0006982022 crossref_primary_10_1111_eci_13339 crossref_primary_10_1111_jce_16625 crossref_primary_10_1186_s13098_024_01354_4 crossref_primary_10_3389_fmed_2024_1365183 crossref_primary_10_7759_cureus_80827 crossref_primary_10_1016_j_ijcard_2021_05_050 crossref_primary_10_1093_ajh_hpaf130 crossref_primary_10_1016_j_eprac_2024_01_016 crossref_primary_10_3390_biomedicines13092123 crossref_primary_10_1210_clinem_dgaa321 crossref_primary_10_1016_j_bcp_2019_113677 crossref_primary_10_2147_DDDT_S371506 crossref_primary_10_1016_j_eprac_2020_10_015 crossref_primary_10_1038_s41574_022_00669_4 crossref_primary_10_1038_s41598_023_48716_y crossref_primary_10_1111_tri_13783 crossref_primary_10_3390_jcm10194325 crossref_primary_10_3390_pharmaceutics14081730 crossref_primary_10_1080_07391102_2024_2326193 crossref_primary_10_2217_fca_2020_0138 crossref_primary_10_1016_j_hfc_2021_05_002 crossref_primary_10_1016_S2213_8587_21_00082_6 crossref_primary_10_1097_XCE_0000000000000181 crossref_primary_10_1161_CIRCULATIONAHA_118_038339 crossref_primary_10_3389_fcvm_2025_1631578 crossref_primary_10_1038_s41598_021_91546_z crossref_primary_10_1096_fj_202200243R crossref_primary_10_1210_clinem_dgac617 crossref_primary_10_1016_j_ccl_2024_12_002 crossref_primary_10_1038_s41598_020_78734_z crossref_primary_10_1007_s40265_021_01538_6 crossref_primary_10_1016_j_jjcc_2022_10_003 crossref_primary_10_1016_S2213_8587_21_00203_5 crossref_primary_10_1002_ehf2_13830 crossref_primary_10_1016_j_jdiacomp_2019_07_005 crossref_primary_10_3390_jcm12155090 crossref_primary_10_1124_jpet_121_000956 crossref_primary_10_1136_openhrt_2023_002364
Cites_doi	10.1161/CIRCULATIONAHA.117.030012 10.1111/dom.12073 10.1161/CIRCULATIONAHA.117.029166 10.1186/s12933-016-0419-0 10.1007/s10741-017-9644-1 10.1111/dom.12572 10.1007/s00125-016-3956-x 10.1016/j.lfs.2018.01.032 10.1111/dom.12127 10.2337/dc16-1312 10.1161/CIRCULATIONAHA.118.033898 10.1016/j.cmet.2016.07.018 10.1016/j.jacc.2017.06.016 10.1056/NEJMoa1504720 10.1016/j.ahj.2018.01.012 10.1161/JAHA.117.005539 10.1002/ejhf.933 10.1152/ajpheart.01058.2004 10.1016/j.ecl.2017.10.007 10.1161/JAHA.117.007046 10.1161/CIRCULATIONAHA.117.032038 10.1016/j.jacbts.2018.01.010 10.1161/CIRCULATIONAHA.117.028268 10.1016/S2213-8587(14)70031-2 10.1186/s12933-017-0658-8 10.2337/db17-0100 10.1016/j.cjca.2017.07.330 10.1002/cpdd.16 10.1186/s12933-017-0654-z 10.1016/j.jacc.2018.01.047 10.1007/s00125-017-4509-7 10.1001/jamacardio.2017.1891 10.1016/S0735-1097(18)31215-4 10.1159/000484633 10.1161/CIRCRESAHA.117.311586 10.1177/1479164114561992 10.1093/eurheartj/ehv728 10.1161/CIRCULATIONAHA.117.029190 10.2337/dc17-1551 10.1093/eurheartj/ehx511 10.1007/s11010-017-3018-9 10.1161/CIRCULATIONAHA.117.029529 10.1016/j.metabol.2017.08.005 10.2337/dc16-0330 10.1001/jamacardio.2017.2275 10.1186/s12933-017-0621-8 10.1016/j.freeradbiomed.2017.01.035 10.1093/eurheartj/ehv134 10.1016/j.carpath.2005.01.005 10.1007/s00125-016-4134-x 10.1152/physrev.00015.2009 10.1161/CIRCULATIONAHA.117.032031 10.1111/dom.13126 10.1056/NEJMoa1611925 10.1007/s00125-012-2579-0 10.1161/JAHA.116.005066 10.2337/dc17-1096 10.1016/j.jacc.2018.02.078 10.1161/CIRCULATIONAHA.118.034222 10.1002/ejhf.1170 10.1007/s00125-018-4644-9 10.1016/j.metabol.2018.02.002 10.1016/j.jacc.2018.03.009 10.1111/dom.13229
ContentType	Journal Article
Copyright	Springer-Verlag GmbH Germany, part of Springer Nature 2018 Diabetologia is a copyright of Springer, (2018). All Rights Reserved.
Copyright_xml	– notice: Springer-Verlag GmbH Germany, part of Springer Nature 2018 – notice: Diabetologia is a copyright of Springer, (2018). All Rights Reserved.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7T5 7X7 7XB 88E 8AO 8C1 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH H94 K9. M0S M1P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8
DOI	10.1007/s00125-018-4670-7
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Immunology Abstracts ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection PML(ProQuest Medical Library) ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE ProQuest One Academic Middle East (New) MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1432-0428
EndPage	2117
ExternalDocumentID	30132036 10_1007_s00125_018_4670_7
Genre	Research Support, Non-U.S. Gov't Journal Article Review
GroupedDBID	--- -53 -5E -5G -BR -EM -Y2 -~C .55 .86 .GJ .VR 06C 06D 0R~ 0VY 199 1CY 1N0 1SB 2.D 203 28- 29F 29G 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 36B 3O- 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5RE 5VS 67Z 6NX 78A 7X7 88E 8AO 8C1 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X A8Z AAAVM AABHQ AACDK AAEWM AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABIPD ABJNI ABJOX ABKCH ABKTR ABLJU ABMNI ABMQK ABNWP ABOCM ABPLI ABQBU ABQSL ABSXP ABTEG ABTKH ABTMW ABULA ABUWG ABUWZ ABWNU ABXPI ACAOD ACBXY ACDTI ACGFS ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACUDM ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADJJI ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFDYV AFEXP AFFNX AFJLC AFKRA AFLOW AFQWF AFWTZ AFZKB AGAYW AGDGC AGJBK AGMZJ AGQEE AGQMX AGRTI AGVAE AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BBWZM BDATZ BENPR BGNMA BPHCQ BSONS BVXVI CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP EBLON EBS EIOEI EJD EMB EMOBN EN4 ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GRRUI GXS H13 HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ IMOTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z J5H JBSCW JCJTX JZLTJ KDC KOV KOW KPH L7B LAS LLZTM M1P M4Y MA- MVM N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P P6G P9S PF0 PQQKQ PROAC PSQYO PT4 Q2X QOK QOR QOS R4E R89 R9I RHV RIG ROL RPX RRX RSV S16 S1Z S26 S27 S28 S37 S3B SAP SCLPG SDE SDH SDM SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 T16 TEORI TR2 TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WH7 WJK WK8 X7M YLTOR Z45 Z7U Z7V Z7W Z82 Z83 Z87 Z8O Z8P Z8Q Z8V Z8W Z91 Z92 ZGI ZMTXR ZOVNA ~EX ~KM AAPKM AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC ADHKG AEZWR AFDZB AFFHD AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY CGR CUY CVF ECM EIF NPM 7T5 7XB 8FK H94 K9. PKEHL PQEST PQUKI PRINS 7X8 ESTFP PUEGO
ID	FETCH-LOGICAL-c551t-f4b9af751051a6257351db3cfc56eff0e37f392ffd27c8252ba25d8e61ec1d283
IEDL.DBID	RSV
ISICitedReferencesCount	715
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000443448100005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0012-186X 1432-0428
IngestDate	Thu Oct 02 05:36:28 EDT 2025 Thu Nov 27 13:42:10 EST 2025 Wed Feb 19 02:32:08 EST 2025 Tue Nov 18 21:04:23 EST 2025 Sat Nov 29 02:07:40 EST 2025 Fri Feb 21 02:35:33 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	10
Keywords	Heart failure Mechanisms Review Cardiovascular effects SGLT2 inhibitors
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c551t-f4b9af751051a6257351db3cfc56eff0e37f392ffd27c8252ba25d8e61ec1d283
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Literature Review-3 ObjectType-Review-3 content type line 23
OpenAccessLink	https://link.springer.com/content/pdf/10.1007/s00125-018-4670-7.pdf
PMID	30132036
PQID	2090923783
PQPubID	48469
PageCount	10
ParticipantIDs	proquest_miscellaneous_2091821033 proquest_journals_2090923783 pubmed_primary_30132036 crossref_primary_10_1007_s00125_018_4670_7 crossref_citationtrail_10_1007_s00125_018_4670_7 springer_journals_10_1007_s00125_018_4670_7
PublicationCentury	2000
PublicationDate	2018-10-01
PublicationDateYYYYMMDD	2018-10-01
PublicationDate_xml	– month: 10 year: 2018 text: 2018-10-01 day: 01
PublicationDecade	2010
PublicationPlace	Berlin/Heidelberg
PublicationPlace_xml	– name: Berlin/Heidelberg – name: Germany – name: Heidelberg
PublicationSubtitle	Clinical, Translational and Experimental Diabetes and Metabolism
PublicationTitle	Diabetologia
PublicationTitleAbbrev	Diabetologia
PublicationTitleAlternate	Diabetologia
PublicationYear	2018
Publisher	Springer Berlin Heidelberg Springer Nature B.V
Publisher_xml	– name: Springer Berlin Heidelberg – name: Springer Nature B.V
References	Santos-Gallego, Ibanez, San Antonio (CR44) 2018; 71 Lytvyn, Bjornstad, Udell, Lovshin, Cherney (CR21) 2017; 136 Lambers Heerspink, de Zeeuw, Wie, Leslie, List (CR32) 2013; 15 Seman, Macha, Nehmiz (CR26) 2013; 2 Ferrannini, Mark, Mayoux (CR39) 2016; 39 Swoboda, McDiarmid, Erhayiem (CR15) 2017; 6 Boonman-de Winter, Rutten, Cramer (CR19) 2012; 55 Baartscheer, Schumacher, Wust (CR48) 2017; 60 McMurray, Gerstein, Holman, Pfeffer (CR9) 2014; 2 Fitchett, Zinman, Wanner (CR5) 2016; 37 Sattar, McLaren, Kristensen, Preiss, McMurray (CR20) 2016; 59 Hallow, Helmlinger, Greasley, McMurray, Boulton (CR33) 2018; 20 Byrne, Parajuli, Levasseur (CR27) 2017; 1 CR3 CR6 Jia, Hill, Sowers (CR12) 2018; 122 Kosiborod, Cavender, Fu (CR16) 2017; 136 Neal, Perkovic, Mahaffey (CR1) 2017; 377 Karg, Bosch, Kannenkeril (CR30) 2018; 17 Singh, Fathi, Vickneson (CR59) 2016; 15 Verma, McMurray, Cherney (CR7) 2017; 2 Fedak, Verma, Weisel, Li (CR50) 2005; 14 Lopaschuk, Verma (CR40) 2016; 24 Fitchett, McKnight, Lee (CR22) 2017; 66 Zinman, Wanner, Lachin (CR2) 2015; 373 Fitchett, Butler, van de Borne (CR4) 2018; 39 Wilcox, Shen, Boulton, Leslie, Griffen (CR34) 2018; 7 Verma, Garg, Yan (CR58) 2016; 39 Mizuno, Harada, Nakagawa (CR42) 2017; 77 Verma, Mazer, Al-Omran (CR62) 2018; 137 Greene, Vaduganathan, Khan (CR11) 2018; 71 Gallo, Wright, Vallon (CR49) 2015; 12 Lau, Dhillon, Yan, Szmitko, Verma (CR53) 2005; 288 Li, Shin, Seo (CR37) 2018; 197 Jorsal, Wiggers, McMurray (CR8) 2018; 47 Lopaschuk, Ussher, Folmes, Jaswal, Stanley (CR41) 2010; 90 Wiviott, Raz, Bonaca (CR65) 2018; 200 Sherman, Bell, Teoh (CR63) 2018; 3 Sato, Aizawa, Yuasa (CR57) 2018; 17 CR18 Heise, Seewaldt-Becker, Macha (CR25) 2013; 15 Chilton, Tikkanen, Cannon (CR36) 2015; 17 Uthman, Baartscheer, Bleijlevens (CR47) 2018; 61 CR14 CR56 Striepe, Jumar, Ott (CR35) 2017; 136 CR55 CR10 Januzzi, Butler, Jarolim (CR60) 2017; 70 Shi, Verma, Yun (CR28) 2017; 433 Al-Jobori, Daniele, Cersosimo (CR24) 2017; 66 Wanner, Lachin, Inzucchi (CR23) 2018; 137 Mahaffey, Neal, Perkovic (CR17) 2018; 137 Packer, Anker, Butler, Filippatos, Zannad (CR46) 2017; 2 Patel, Shah, Verma, Oudit (CR54) 2017; 22 Verma, Bhatt, Bain (CR64) 2018; 137 Kang, Verma, Teng (CR52) 2017; 33 Seferovic, Paulus (CR13) 2015; 36 Inzucchi, Iliev, Pfarr, Zinman (CR61) 2018; 41 Solini, Giannini, Seghieri (CR38) 2017; 16 Jardine, Mahaffey, Neal (CR66) 2017; 46 Lee, Chang, Lin (CR51) 2017; 104 Kappel, Lehrke, Schutt (CR45) 2017; 136 Gormsen, Svart, Thomsen (CR43) 2017; 6 Butler, Hamo, Filippatos (CR29) 2017; 19 Inzucchi, Zinman, Fitchett (CR31) 2018; 41 KW Mahaffey (4670_CR17) 2018; 137 DC Lau (4670_CR53) 2005; 288 SJ Greene (4670_CR11) 2018; 71 D Fitchett (4670_CR5) 2016; 37 JJ McMurray (4670_CR9) 2014; 2 T Heise (4670_CR25) 2013; 15 A Solini (4670_CR38) 2017; 16 MV Karg (4670_CR30) 2018; 17 J Butler (4670_CR29) 2017; 19 SE Inzucchi (4670_CR61) 2018; 41 JL Januzzi Jr (4670_CR60) 2017; 70 D Fitchett (4670_CR4) 2018; 39 GD Lopaschuk (4670_CR40) 2016; 24 Y Mizuno (4670_CR42) 2017; 77 SE Inzucchi (4670_CR31) 2018; 41 HJ Lambers Heerspink (4670_CR32) 2013; 15 PP Swoboda (4670_CR15) 2017; 6 X Shi (4670_CR28) 2017; 433 LA Gallo (4670_CR49) 2015; 12 B Neal (4670_CR1) 2017; 377 4670_CR18 L Seman (4670_CR26) 2013; 2 S Kang (4670_CR52) 2017; 33 CG Santos-Gallego (4670_CR44) 2018; 71 4670_CR14 KM Hallow (4670_CR33) 2018; 20 NJ Byrne (4670_CR27) 2017; 1 4670_CR56 SD Wiviott (4670_CR65) 2018; 200 4670_CR55 4670_CR10 BA Kappel (4670_CR45) 2017; 136 G Jia (4670_CR12) 2018; 122 C Wanner (4670_CR23) 2018; 137 H Al-Jobori (4670_CR24) 2017; 66 GD Lopaschuk (4670_CR41) 2010; 90 L Uthman (4670_CR47) 2018; 61 E Ferrannini (4670_CR39) 2016; 39 4670_CR3 D Fitchett (4670_CR22) 2017; 66 4670_CR6 S Verma (4670_CR7) 2017; 2 M Kosiborod (4670_CR16) 2017; 136 N Sattar (4670_CR20) 2016; 59 T Sato (4670_CR57) 2018; 17 LJ Boonman-de Winter (4670_CR19) 2012; 55 S Verma (4670_CR62) 2018; 137 TM Lee (4670_CR51) 2017; 104 SE Sherman (4670_CR63) 2018; 3 A Jorsal (4670_CR8) 2018; 47 H Li (4670_CR37) 2018; 197 LC Gormsen (4670_CR43) 2017; 6 CS Wilcox (4670_CR34) 2018; 7 PM Seferovic (4670_CR13) 2015; 36 S Verma (4670_CR64) 2018; 137 Y Lytvyn (4670_CR21) 2017; 136 M Packer (4670_CR46) 2017; 2 A Baartscheer (4670_CR48) 2017; 60 MJ Jardine (4670_CR66) 2017; 46 B Zinman (4670_CR2) 2015; 373 S Verma (4670_CR58) 2016; 39 JS Singh (4670_CR59) 2016; 15 R Chilton (4670_CR36) 2015; 17 PW Fedak (4670_CR50) 2005; 14 VB Patel (4670_CR54) 2017; 22 K Striepe (4670_CR35) 2017; 136
References_xml	– volume: 136 start-page: 1643 year: 2017 end-page: 1658 ident: CR21 article-title: Sodium glucose cotransporter-2 inhibition in heart failure: potential mechanisms, clinical applications, and summary of clinical trials publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.030012 – volume: 15 start-page: 613 year: 2013 end-page: 621 ident: CR25 article-title: Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeksʼ treatment with empagliflozin once daily in patients with type 2 diabetes publication-title: Diabetes Obes Metab doi: 10.1111/dom.12073 – volume: 1 start-page: 347 year: 2017 end-page: 354 ident: CR27 article-title: Empagliflozin prevents worsening of cardiac function in an experimental model of pressure overload-induced heart failure publication-title: JACC: Basic Translational Sci – volume: 136 start-page: 969 year: 2017 end-page: 972 ident: CR45 article-title: Effect of empagliflozin on the metabolic signature of patients with type 2 diabetes mellitus and cardiovascular disease publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.029166 – volume: 15 start-page: 97 year: 2016 ident: CR59 article-title: Research into the effect of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-016-0419-0 – volume: 22 start-page: 889 year: 2017 end-page: 902 ident: CR54 article-title: Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease publication-title: Heart Fail Rev doi: 10.1007/s10741-017-9644-1 – volume: 17 start-page: 1180 year: 2015 end-page: 1193 ident: CR36 article-title: Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes publication-title: Diabetes Obes Metab doi: 10.1111/dom.12572 – volume: 59 start-page: 1333 year: 2016 end-page: 1339 ident: CR20 article-title: SGLT2 inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms? publication-title: Diabetologia doi: 10.1007/s00125-016-3956-x – volume: 197 start-page: 46 year: 2018 end-page: 55 ident: CR37 article-title: The anti-diabetic drug dapagliflozin induces vasodilation via activation of PKG and Kv channels publication-title: Life Sci doi: 10.1016/j.lfs.2018.01.032 – volume: 15 start-page: 853 year: 2013 end-page: 862 ident: CR32 article-title: Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes publication-title: Diabetes Obes Metab doi: 10.1111/dom.12127 – volume: 39 start-page: e212 year: 2016 end-page: e213 ident: CR58 article-title: Effect of empagliflozin on left ventricular mass and diastolic function in individuals with diabetes: an important clue to the EMPA-REG OUTCOME trial? publication-title: Diabetes Care doi: 10.2337/dc16-1312 – volume: 137 start-page: 2179 year: 2018 end-page: 2183 ident: CR64 article-title: Effects of liraglutide on cardiovascular events in patients with type 2 diabetes and polyvascular disease: results of the LEADER trial publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.118.033898 – volume: 24 start-page: 200 year: 2016 end-page: 202 ident: CR40 article-title: Empagliflozin’s fuel hypothesis: not so soon publication-title: Cell Metab doi: 10.1016/j.cmet.2016.07.018 – volume: 70 start-page: 704 year: 2017 end-page: 712 ident: CR60 article-title: Effects of canagliflozin on cardiovascular biomarkers in older adults with type 2 diabetes publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2017.06.016 – volume: 373 start-page: 2117 year: 2015 end-page: 2128 ident: CR2 article-title: Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes publication-title: N Engl J Med doi: 10.1056/NEJMoa1504720 – volume: 200 start-page: 83 year: 2018 end-page: 89 ident: CR65 article-title: The design and rationale for the dapagliflozin effect on cardiovascular events (DECLARE) – TIMI 58 Trial publication-title: Am Heart J doi: 10.1016/j.ahj.2018.01.012 – volume: 6 start-page: e005539 year: 2017 ident: CR15 article-title: Diabetes mellitus, microalbuminuria, and subclinical cardiac disease: identification and monitoring of individuals at risk of heart failure publication-title: J Am Heart Assoc doi: 10.1161/JAHA.117.005539 – volume: 19 start-page: 1390 year: 2017 end-page: 1400 ident: CR29 article-title: The potential role and rationale for treatment of heart failure with sodium-glucose co-transporter 2 inhibitors publication-title: Eur J Heart Fail doi: 10.1002/ejhf.933 – volume: 288 start-page: H2031 year: 2005 end-page: H2041 ident: CR53 article-title: Adipokines: molecular links between obesity and atherosclerosis publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.01058.2004 – volume: 47 start-page: 117 year: 2018 end-page: 135 ident: CR8 article-title: Heart failure: epidemiology, pathophysiology, and management of heart failure in diabetes mellitus publication-title: Endocrinol Metab Clin N Am doi: 10.1016/j.ecl.2017.10.007 – volume: 7 start-page: e007046 year: 2018 ident: CR34 article-title: Interaction between the sodium-glucose-linked transporter 2 inhibitor dapagliflozin and the loop diuretic bumetanide in normal human subjects publication-title: J Am Heart Assoc doi: 10.1161/JAHA.117.007046 – volume: 137 start-page: 323 year: 2018 end-page: 334 ident: CR17 article-title: Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS Program (Canagliflozin Cardiovascular Assessment Study) publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.032038 – volume: 3 start-page: 327 year: 2018 end-page: 329 ident: CR63 article-title: Canagliflozin improves the recovery of blood flow in an experimental model of severe limb ischemia publication-title: JACC Basic Translational Sci doi: 10.1016/j.jacbts.2018.01.010 – volume: 137 start-page: 119 year: 2018 end-page: 129 ident: CR23 article-title: Empagliflozin and clinical outcomes in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.028268 – volume: 2 start-page: 843 year: 2014 end-page: 851 ident: CR9 article-title: Heart failure: a cardiovascular outcome in diabetes that can no longer be ignored publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(14)70031-2 – volume: 17 start-page: 6 year: 2018 ident: CR57 article-title: The effect of dapagliflozin treatment on epicardial adipose tissue volume publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-017-0658-8 – volume: 66 start-page: 1999 year: 2017 end-page: 2006 ident: CR24 article-title: Empagliflozin and kinetics of renal glucose transport in healthy individuals and individuals with type 2 diabetes publication-title: Diabetes doi: 10.2337/db17-0100 – volume: 33 start-page: S169 year: 2017 ident: CR52 article-title: Direct effects of empagliflozin on extracellular matrix remodeling in human cardiac fibroblasts: novel translational clues to EMPA-REG Outcome publication-title: Can J Cardiol doi: 10.1016/j.cjca.2017.07.330 – ident: CR18 – ident: CR14 – volume: 2 start-page: 152 year: 2013 end-page: 161 ident: CR26 article-title: Empagliflozin (BI 10773), a potent and selective sglt2 inhibitor, induces dose-dependent glucosuria in healthy subjects publication-title: Clin Pharmacol Drug Dev doi: 10.1002/cpdd.16 – volume: 17 start-page: 5 year: 2018 ident: CR30 article-title: SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-017-0654-z – volume: 71 start-page: 1379 year: 2018 end-page: 1390 ident: CR11 article-title: Prevalent and incident heart failure in cardiovascular outcome trials of patients with type 2 diabetes publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2018.01.047 – volume: 61 start-page: 722 year: 2018 end-page: 726 ident: CR47 article-title: Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na /H exchanger, lowering of cytosolic Na and vasodilation publication-title: Diabetologia doi: 10.1007/s00125-017-4509-7 – ident: CR10 – volume: 2 start-page: 939 year: 2017 end-page: 940 ident: CR7 article-title: The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweet spot in heart failure publication-title: JAMA Cardiol doi: 10.1001/jamacardio.2017.1891 – ident: CR6 – volume: 71 start-page: A674 year: 2018 ident: CR44 article-title: Empagliflozin induces a myocardial metabolic shift from glucose consumption to ketone metabolism that mitigates adverse cardiac remodeling and improves myocardial contractility publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(18)31215-4 – volume: 46 start-page: 462 year: 2017 end-page: 472 ident: CR66 article-title: The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study rationale, design, and baseline characteristics publication-title: Am J Nephrol doi: 10.1159/000484633 – ident: CR56 – volume: 122 start-page: 624 year: 2018 end-page: 638 ident: CR12 article-title: Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity publication-title: Circ Res doi: 10.1161/CIRCRESAHA.117.311586 – volume: 12 start-page: 78 year: 2015 end-page: 89 ident: CR49 article-title: Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences publication-title: Diab Vasc Dis Res doi: 10.1177/1479164114561992 – volume: 37 start-page: 1526 year: 2016 end-page: 1534 ident: CR5 article-title: Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial publication-title: Eur Heart J doi: 10.1093/eurheartj/ehv728 – volume: 136 start-page: 249 year: 2017 end-page: 259 ident: CR16 article-title: Lower risk of heart failure and death in patients initiated on sodium-glucose cotransporter-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL study (comparative effectiveness of cardiovascular outcomes in new users of sodium-glucose cotransporter-2 inhibitors) publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.029190 – volume: 66 start-page: A312 year: 2017 end-page: A313 ident: CR22 article-title: Empagliflozin (EMPA) reduces heart failure irrespective of control of blood pressure (BP), low density lipoprotein cholesterol (LDL-C), and HbA1c publication-title: Diabetes – volume: 41 start-page: e4 year: 2018 end-page: e5 ident: CR61 article-title: Empagliflozin and assessment of lower-limb amputations in the EMPA-REG OUTCOME trial publication-title: Diabetes Care doi: 10.2337/dc17-1551 – volume: 39 start-page: 363 year: 2018 end-page: 370 ident: CR4 article-title: Effects of empagliflozin on risk for cardiovascular death and heart failure hospitalization across the spectrum of heart failure risk in the EMPA-REG OUTCOME® trial publication-title: Eur Heart J doi: 10.1093/eurheartj/ehx511 – volume: 433 start-page: 97 year: 2017 end-page: 102 ident: CR28 article-title: Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial? publication-title: Mol Cell Biochem doi: 10.1007/s11010-017-3018-9 – volume: 136 start-page: 1167 year: 2017 end-page: 1169 ident: CR35 article-title: Effects of the selective sodium-glucose cotransporter 2 inhibitor empagliflozin on vascular function and central hemodynamics in patients with type 2 diabetes mellitus publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.029529 – volume: 77 start-page: 65 year: 2017 end-page: 72 ident: CR42 article-title: The diabetic heart utilizes ketone bodies as an energy source publication-title: Metabolism doi: 10.1016/j.metabol.2017.08.005 – volume: 39 start-page: 1108 year: 2016 end-page: 1114 ident: CR39 article-title: CV protection in the EMPA-REG OUTCOME Trial: a “Thrifty Substrate” hypothesis publication-title: Diabetes Care doi: 10.2337/dc16-0330 – volume: 2 start-page: 1025 year: 2017 end-page: 1029 ident: CR46 article-title: Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action publication-title: JAMA Cardiol doi: 10.1001/jamacardio.2017.2275 – ident: CR3 – volume: 16 start-page: 138 year: 2017 ident: CR38 article-title: Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-017-0621-8 – volume: 104 start-page: 298 year: 2017 end-page: 310 ident: CR51 article-title: Dapagliflozin, a selective SGLT2 inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2017.01.035 – volume: 36 start-page: 1718 year: 2015 end-page: 1727 ident: CR13 article-title: Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes publication-title: Eur Heart J doi: 10.1093/eurheartj/ehv134 – volume: 14 start-page: 49 year: 2005 end-page: 60 ident: CR50 article-title: Cardiac remodeling and failure from molecules to man (part II) publication-title: Cardiovasc Pathol doi: 10.1016/j.carpath.2005.01.005 – volume: 60 start-page: 568 year: 2017 end-page: 573 ident: CR48 article-title: Empagliflozin decreases myocardial cytoplasmic Na through inhibition of the cardiac Na /H exchanger in rats and rabbits publication-title: Diabetologia doi: 10.1007/s00125-016-4134-x – volume: 90 start-page: 207 year: 2010 end-page: 258 ident: CR41 article-title: Myocardial fatty acid metabolism in health and disease publication-title: Physiol Rev doi: 10.1152/physrev.00015.2009 – ident: CR55 – volume: 137 start-page: 405 year: 2018 end-page: 407 ident: CR62 article-title: Cardiovascular outcomes and safety of empagliflozin in patients with type 2 diabetes mellitus and peripheral artery disease: a subanalysis of EMPA-REG OUTCOME publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.032031 – volume: 20 start-page: 479 year: 2018 end-page: 487 ident: CR33 article-title: Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis publication-title: Diabetes Obes Metab doi: 10.1111/dom.13126 – volume: 377 start-page: 644 year: 2017 end-page: 657 ident: CR1 article-title: Canagliflozin and cardiovascular and renal events in type 2 diabetes publication-title: N Engl J Med doi: 10.1056/NEJMoa1611925 – volume: 55 start-page: 2154 year: 2012 end-page: 2162 ident: CR19 article-title: High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes publication-title: Diabetologia doi: 10.1007/s00125-012-2579-0 – volume: 6 start-page: e005066 year: 2017 ident: CR43 article-title: Ketone body infusion with 3-hydroxybutyrate reduces myocardial glucose uptake and increases blood flow in humans: a positron emission tomography study publication-title: J Am Heart Assoc doi: 10.1161/JAHA.116.005066 – volume: 41 start-page: 356 year: 2018 end-page: 363 ident: CR31 article-title: How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME trial publication-title: Diabetes Care doi: 10.2337/dc17-1096 – volume: 2 start-page: 152 year: 2013 ident: 4670_CR26 publication-title: Clin Pharmacol Drug Dev doi: 10.1002/cpdd.16 – volume: 41 start-page: 356 year: 2018 ident: 4670_CR31 publication-title: Diabetes Care doi: 10.2337/dc17-1096 – volume: 66 start-page: A312 year: 2017 ident: 4670_CR22 publication-title: Diabetes – volume: 71 start-page: A674 year: 2018 ident: 4670_CR44 publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(18)31215-4 – volume: 39 start-page: 363 year: 2018 ident: 4670_CR4 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehx511 – volume: 39 start-page: e212 year: 2016 ident: 4670_CR58 publication-title: Diabetes Care doi: 10.2337/dc16-1312 – ident: 4670_CR14 doi: 10.1016/j.jacc.2018.02.078 – volume: 37 start-page: 1526 year: 2016 ident: 4670_CR5 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehv728 – volume: 55 start-page: 2154 year: 2012 ident: 4670_CR19 publication-title: Diabetologia doi: 10.1007/s00125-012-2579-0 – volume: 200 start-page: 83 year: 2018 ident: 4670_CR65 publication-title: Am Heart J doi: 10.1016/j.ahj.2018.01.012 – volume: 39 start-page: 1108 year: 2016 ident: 4670_CR39 publication-title: Diabetes Care doi: 10.2337/dc16-0330 – volume: 2 start-page: 1025 year: 2017 ident: 4670_CR46 publication-title: JAMA Cardiol doi: 10.1001/jamacardio.2017.2275 – volume: 373 start-page: 2117 year: 2015 ident: 4670_CR2 publication-title: N Engl J Med doi: 10.1056/NEJMoa1504720 – volume: 61 start-page: 722 year: 2018 ident: 4670_CR47 publication-title: Diabetologia doi: 10.1007/s00125-017-4509-7 – volume: 137 start-page: 323 year: 2018 ident: 4670_CR17 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.032038 – volume: 47 start-page: 117 year: 2018 ident: 4670_CR8 publication-title: Endocrinol Metab Clin N Am doi: 10.1016/j.ecl.2017.10.007 – volume: 17 start-page: 5 year: 2018 ident: 4670_CR30 publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-017-0654-z – volume: 104 start-page: 298 year: 2017 ident: 4670_CR51 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2017.01.035 – volume: 77 start-page: 65 year: 2017 ident: 4670_CR42 publication-title: Metabolism doi: 10.1016/j.metabol.2017.08.005 – volume: 19 start-page: 1390 year: 2017 ident: 4670_CR29 publication-title: Eur J Heart Fail doi: 10.1002/ejhf.933 – volume: 377 start-page: 644 year: 2017 ident: 4670_CR1 publication-title: N Engl J Med doi: 10.1056/NEJMoa1611925 – volume: 22 start-page: 889 year: 2017 ident: 4670_CR54 publication-title: Heart Fail Rev doi: 10.1007/s10741-017-9644-1 – ident: 4670_CR6 doi: 10.1161/CIRCULATIONAHA.118.034222 – volume: 136 start-page: 249 year: 2017 ident: 4670_CR16 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.029190 – volume: 1 start-page: 347 year: 2017 ident: 4670_CR27 publication-title: JACC: Basic Translational Sci – volume: 288 start-page: H2031 year: 2005 ident: 4670_CR53 publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.01058.2004 – volume: 6 start-page: e005539 year: 2017 ident: 4670_CR15 publication-title: J Am Heart Assoc doi: 10.1161/JAHA.117.005539 – volume: 24 start-page: 200 year: 2016 ident: 4670_CR40 publication-title: Cell Metab doi: 10.1016/j.cmet.2016.07.018 – volume: 16 start-page: 138 year: 2017 ident: 4670_CR38 publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-017-0621-8 – volume: 17 start-page: 1180 year: 2015 ident: 4670_CR36 publication-title: Diabetes Obes Metab doi: 10.1111/dom.12572 – volume: 14 start-page: 49 year: 2005 ident: 4670_CR50 publication-title: Cardiovasc Pathol doi: 10.1016/j.carpath.2005.01.005 – ident: 4670_CR10 doi: 10.1002/ejhf.1170 – volume: 36 start-page: 1718 year: 2015 ident: 4670_CR13 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehv134 – volume: 41 start-page: e4 year: 2018 ident: 4670_CR61 publication-title: Diabetes Care doi: 10.2337/dc17-1551 – volume: 71 start-page: 1379 year: 2018 ident: 4670_CR11 publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2018.01.047 – ident: 4670_CR3 doi: 10.1007/s00125-018-4644-9 – volume: 136 start-page: 1643 year: 2017 ident: 4670_CR21 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.030012 – volume: 33 start-page: S169 year: 2017 ident: 4670_CR52 publication-title: Can J Cardiol doi: 10.1016/j.cjca.2017.07.330 – volume: 197 start-page: 46 year: 2018 ident: 4670_CR37 publication-title: Life Sci doi: 10.1016/j.lfs.2018.01.032 – volume: 6 start-page: e005066 year: 2017 ident: 4670_CR43 publication-title: J Am Heart Assoc doi: 10.1161/JAHA.116.005066 – ident: 4670_CR56 doi: 10.1016/j.metabol.2018.02.002 – volume: 2 start-page: 939 year: 2017 ident: 4670_CR7 publication-title: JAMA Cardiol doi: 10.1001/jamacardio.2017.1891 – volume: 66 start-page: 1999 year: 2017 ident: 4670_CR24 publication-title: Diabetes doi: 10.2337/db17-0100 – volume: 90 start-page: 207 year: 2010 ident: 4670_CR41 publication-title: Physiol Rev doi: 10.1152/physrev.00015.2009 – volume: 433 start-page: 97 year: 2017 ident: 4670_CR28 publication-title: Mol Cell Biochem doi: 10.1007/s11010-017-3018-9 – volume: 136 start-page: 1167 year: 2017 ident: 4670_CR35 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.029529 – volume: 122 start-page: 624 year: 2018 ident: 4670_CR12 publication-title: Circ Res doi: 10.1161/CIRCRESAHA.117.311586 – ident: 4670_CR18 doi: 10.1016/j.jacc.2018.03.009 – volume: 15 start-page: 97 year: 2016 ident: 4670_CR59 publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-016-0419-0 – volume: 59 start-page: 1333 year: 2016 ident: 4670_CR20 publication-title: Diabetologia doi: 10.1007/s00125-016-3956-x – volume: 15 start-page: 853 year: 2013 ident: 4670_CR32 publication-title: Diabetes Obes Metab doi: 10.1111/dom.12127 – volume: 137 start-page: 405 year: 2018 ident: 4670_CR62 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.032031 – volume: 137 start-page: 2179 year: 2018 ident: 4670_CR64 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.118.033898 – volume: 15 start-page: 613 year: 2013 ident: 4670_CR25 publication-title: Diabetes Obes Metab doi: 10.1111/dom.12073 – volume: 2 start-page: 843 year: 2014 ident: 4670_CR9 publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(14)70031-2 – volume: 46 start-page: 462 year: 2017 ident: 4670_CR66 publication-title: Am J Nephrol doi: 10.1159/000484633 – volume: 136 start-page: 969 year: 2017 ident: 4670_CR45 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.029166 – volume: 12 start-page: 78 year: 2015 ident: 4670_CR49 publication-title: Diab Vasc Dis Res doi: 10.1177/1479164114561992 – ident: 4670_CR55 doi: 10.1111/dom.13229 – volume: 137 start-page: 119 year: 2018 ident: 4670_CR23 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.028268 – volume: 17 start-page: 6 year: 2018 ident: 4670_CR57 publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-017-0658-8 – volume: 7 start-page: e007046 year: 2018 ident: 4670_CR34 publication-title: J Am Heart Assoc doi: 10.1161/JAHA.117.007046 – volume: 60 start-page: 568 year: 2017 ident: 4670_CR48 publication-title: Diabetologia doi: 10.1007/s00125-016-4134-x – volume: 3 start-page: 327 year: 2018 ident: 4670_CR63 publication-title: JACC Basic Translational Sci doi: 10.1016/j.jacbts.2018.01.010 – volume: 20 start-page: 479 year: 2018 ident: 4670_CR33 publication-title: Diabetes Obes Metab doi: 10.1111/dom.13126 – volume: 70 start-page: 704 year: 2017 ident: 4670_CR60 publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2017.06.016
SSID	ssj0003546
Score	2.7040572
SecondaryResourceType	review_article
Snippet	Sodium–glucose cotransporter (SGLT)2 inhibitors have been demonstrated to reduce cardiovascular events, particularly heart failure, in cardiovascular outcome... Sodium-glucose cotransporter (SGLT)2 inhibitors have been demonstrated to reduce cardiovascular events, particularly heart failure, in cardiovascular outcome...
SourceID	proquest pubmed crossref springer
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	2108
SubjectTerms	Adipokines - metabolism Animals Benzhydryl Compounds - pharmacology Blood Glucose - metabolism Cardiovascular Diseases - complications Cardiovascular Diseases - drug therapy Diabetes Complications - complications Diabetes Complications - drug therapy Diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diuresis Glucosides - pharmacology Heart - drug effects Heart diseases Heart failure Heart Ventricles - drug effects Heart Ventricles - pathology Human Physiology Humans Hypoglycemic Agents - pharmacology Internal Medicine Kidney - drug effects Medicine Medicine & Public Health Metabolic Diseases Na+/glucose cotransporter Na+/H+-exchanging ATPase Review Sodium Sodium-Glucose Transporter 2 Inhibitors - pharmacology Structure-function relationships Ventricle
SummonAdditionalLinks	– databaseName: Public Health Database dbid: 8C1 link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1JT9wwFH5iqRCXAoXSYamMxAlkKbGTscOlqlBpDy1CYpDmFnlVI5WEkqG_v88eZ0YIlUvPcRwrb_ue3wZwqpkViBoKypVGB6UsS1ox76izSlnJDPO5jsMmxPW1nE6rm3Th1qe0ykEnRkVtOxPuyNFJrzIEI0LyTw-_aZgaFaKraYTGKqznLCuCYMrLZYoHT4U6qIRpLsfTIaqZxSaiaNrRkZYUVUVGxXO79AJsvgiURvtztfW_J9-Gtwl5ks9zVtmBFde-g40fKba-C5Pbr98njDTtz0Y3YQYPUa0l9y6UBjf9fU86T8yz7FWiUVH6ZnZBFImFSbTzFAFlyLYj85qYPbi7-jK5_EbTzAVqEDvNqC90pbwIsCtX6BsJXuZWc-NNOXbeZ44Lj5DKe8uEQe-SacVKK904dya3iFXew1rbte4DEK5EZBArDeIAWWhXcVf4iumqKpyQI8iGP16b1JA8zMX4VS9aKUci1UikOhCpFiM4W7zyMO_G8drio4EedRLMvl4SYwQni8coUiFOolrXPcU16HXlGcc1-3PyL77GQ2wKrf4Izgd-WG7-z6McvH6UQ9hkgRNjjuARrM0en9wxvDF_Zk3_-DHy9F8w_vpd priority: 102 providerName: ProQuest
Title	SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review
URI	https://link.springer.com/article/10.1007/s00125-018-4670-7 https://www.ncbi.nlm.nih.gov/pubmed/30132036 https://www.proquest.com/docview/2090923783 https://www.proquest.com/docview/2091821033
Volume	61
WOSCitedRecordID	wos000443448100005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1432-0428 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003546 issn: 0012-186X databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dT9wwDLfGMU17GWNfHGOnTNoTKFKbtJd0bwzB9gAnBAe6tyqfotLoIXrH34-Ta4sQbNL2kpc6aeTY8c-yHQN808wKRA0Z5Uqjg5LnOS2Yd9RZpaxkhvlUx2YTYjKRs1lx2tZxN122exeSjDd1X-wWLHNINJMUlTuhYg3W0drJoI1n55f99cvb6hykpqkcz7pQ5nNLPDZGTxDmk-hoNDpHG_-13bfwpsWYZH8lFJvwwtXv4NVJG0V_D9Pzn8dTRqr6qtJV6LZDVG3JtQtFwFVz3ZC5J-ZRnirReCX6avGdKBJLkOjcU4SOIa-OrKpfPsDF0eH04BdtuytQgyhpQX2mC-VFAFipQi9I8Dy1mhtv8rHzPnFceARP3lsmDPqRTCuWW-nGqTOpRVTyEQb1vHZbQLgSURSsNGjxZaZdwV3mC6aLInNCDiHp2Fya9unx0AHjd9k_mhy5VSK3ysCtUgxht59ys3p342_EO93Zla0KNiVLigTRq5B8CF_7z6g8ISKiajdfRhr0r9KEI82n1Zn3f-MhCoX2fQh73QE_LP7HrWz_E_VneM2ChMTkwB0YLG6X7gu8NHeLqrkdwZqYiThKHOVBOoL1H4eT07NRlPh7La70Qw
linkProvider	Springer Nature
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1ba9RAFD7UKuqL98tq1RH0RRlIZpKdiSAi1drS7SK4wr6lc6WBNqnNVvFP-Rs9M0l2KcW-9cHnTCaTnNt3cm4ArzSzAlFDRrnS6KDkeU4L5h11VikrmWE-1XHYhJhO5XxefF2DP0MtTEirHHRiVNS2MeEfOTrpRYJgREj-4fgHDVOjQnR1GKHRscWu-_0LXbb2_c4npO9rxrY-zza3aT9VgBpEBwvqM10oLwKwSBWif8Hz1GpuvMnHzvvEceERNHhvmTDoPzGtWG6lG6fOpBatMe57Ba6GTnbB2ZObq5QS3hcGodKnqRzPhyhqEpuWIpRAx11SVE0JFWft4Dlwey4wG-3d1u3_7UvdgVs9siYfO1G4C2uuvgfX9_rcgfsw-_ZlMmOkqg8qXYUZQ0TVlhy5UPpctUctaTwxZ7JziUZD4KvFO6JILLyijacImEM2Ielqfh7A90t5p4ewXje1ewyEKxEFwEqDOEdm2hXcZb5guigyJ-QIkoHCpekbroe5H4flslV0ZIoSmaIMTFGKEbxZ3nLcdRu5aPHGQP-yVzxtuSL-CF4uL6PKCHEgVbvmNK5BrzJNOK551LHb8mk8xN4Q1Yzg7cB_q83_eZQnFx_lBdzYnu1NysnOdPcp3GRBCmI-5AasL05O3TO4Zn4uqvbkeZQnAvuXzZZ_AW5zWDQ
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgiouvKELBYwEF5BFYidrBwkh1LJQtawqsUh7C36KSG1Smi2Iv8avY-wku6oqeuuBcxzHiT_PfJN5ATzXzApkDRnlSqOBkuc5LZh31FmlrGSG-VTHZhNiOpXzeXGwBn-GXJgQVjnIxCiobWPCP3I00osEyYiQ_LXvwyIOdibvjn_Q0EEqeFqHdhodRPbc719ovrVvd3dwr18wNvkw2_5E-w4D1CBTWFCf6UJ5EUhGqtASEDxPrebGm3zsvE8cFx4JhPeWCYO2FNOK5Va6cepMalEz47xX4KrgiOKQpb69Ci_hfZIQKgCayvF88KgmsYAp0go04iVFMZVQcVYnniO655y0UfdNbv7PX-0W3OgZN3nfHZHbsObqO7DxuY8puAuzLx_3Z4xU9fdKV6H3EFG1JUcupERX7VFLGk_MmahdolFB-GrxhigSE7Jo4ykS6RBlSLpcoHvw9VLe6T6s103tNoFwJeLBsNIg_5GZdgV3mS-YLorMCTmCZNjt0vSF2EM_kMNyWUI6AqREgJQBIKUYwcvlLcddFZKLBm8NWCh7gdSWKyCM4NnyMoqS4B9StWtO4xi0NtOE45gHHfSWT-PBJ4dsZwSvBiyuJv_nUh5evJSnsIFoLPd3p3uP4DoLByKGSW7B-uLk1D2Ga-bnompPnsSjReDbZaPyL4M6YPk
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=SGLT2+inhibitors+and+mechanisms+of+cardiovascular+benefit%3A+a+state-of-the-art+review&rft.jtitle=Diabetologia&rft.au=Verma%2C+Subodh&rft.au=McMurray%2C+John+J.+V.&rft.date=2018-10-01&rft.issn=0012-186X&rft.eissn=1432-0428&rft.volume=61&rft.issue=10&rft.spage=2108&rft.epage=2117&rft_id=info:doi/10.1007%2Fs00125-018-4670-7&rft.externalDBID=n%2Fa&rft.externalDocID=10_1007_s00125_018_4670_7
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0012-186X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0012-186X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0012-186X&client=summon