Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage

Meiotic crossovers are limited in number and are prevented from occurring close to each other by crossover interference. In many species, crossover number is subject to sexual dimorphism, and a lower crossover number is associated with shorter chromosome axes lengths. How this patterning is imposed...

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Published in:Nature communications Vol. 13; no. 1; pp. 5999 - 13
Main Authors: Durand, Stéphanie, Lian, Qichao, Jing, Juli, Ernst, Marcel, Grelon, Mathilde, Zwicker, David, Mercier, Raphael
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 12.10.2022
Nature Publishing Group
Nature Portfolio
Subjects:
14/1
14/19
14/63
45/22
45/23
45/70
631/208/1405
631/337/149
631/449/2491/1559
631/80/103
64
Chromosomes
Diffusion
Females
Genetics
Humanities and Social Sciences
Interference
Life Sciences
Males
Mathematical models
Meiosis
multidisciplinary
Mutation
Plants genetics
Proteins
Science
Science (multidisciplinary)
Sexual dimorphism
Synaptonemal complex
ISSN:2041-1723, 2041-1723
Online Access:Get full text
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Summary:Meiotic crossovers are limited in number and are prevented from occurring close to each other by crossover interference. In many species, crossover number is subject to sexual dimorphism, and a lower crossover number is associated with shorter chromosome axes lengths. How this patterning is imposed remains poorly understood. Here, we show that overexpression of the Arabidopsis pro-crossover protein HEI10 increases crossovers but maintains some interference and sexual dimorphism. Disrupting the synaptonemal complex by mutating ZYP1 also leads to an increase in crossovers but, in contrast, abolishes interference and disrupts the link between chromosome axis length and crossovers. Crucially, combining HEI10 overexpression and zyp1 mutation leads to a massive and unprecedented increase in crossovers. These observations support and can be predicted by, a recently proposed model in which HEI10 diffusion along the synaptonemal complex drives a coarsening process leading to well-spaced crossover-promoting foci, providing a mechanism for crossover patterning. During meiosis, the number and distribution of crossovers (COs) are tightly controlled, but the mechanistic basis of this control is unclear. Here, by combining experimental data and mathematical modeling, the study advocates a CO patterning model via coarsening through the diffusion of HEI10 along the synaptonemal complex.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-022-33472-w