BDNF Polymorphism: A Review of Its Diagnostic and Clinical Relevance in Neurodegenerative Disorders

Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development, differentiation, and survival in the developing and adult nervous system. A common single-nucleotide polymorphism in the pro-region of the human BDNF gene, resulting in a valine to methionine substitution (Val66M...

Full description

Saved in:
Bibliographic Details
Published in:Aging and disease Vol. 9; no. 3; pp. 523 - 536
Main Authors: Shen, Ting, You, Yuyi, Joseph, Chitra, Mirzaei, Mehdi, Klistorner, Alexander, Graham, Stuart L., Gupta, Vivek
Format: Journal Article
Language:English
Published: United States JKL International 01.06.2018
JKL International LLC
Subjects:
Brain-derived neurotrophic factor
Diagnosis
Genetic aspects
Genetic polymorphisms
Neurodegenerative diseases
Review
neurodegenerative diseases
polymorphism
Alzheimer’s disease
BDNF
glaucoma
multiple sclerosis
ISSN:2152-5250, 2152-5250
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development, differentiation, and survival in the developing and adult nervous system. A common single-nucleotide polymorphism in the pro-region of the human BDNF gene, resulting in a valine to methionine substitution (Val66Met), has been associated with the susceptibility, incidence, and clinical features of several neurodegenerative disorders. Much research has been dedicated to evaluating the effects of polymorphism in the past decade, and functional effects of this genetic variation. A better understanding of how this naturally occurring polymorphism associates with or influences physiology, anatomy, and cognition in both healthy and diseased adults in neurodegenerative conditions will help understand neurochemical mechanisms and definable clinical outcomes in humans. Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). Several controversies and unresolved issues, including small effect sizes, possible ethnicity, gender, and age effects of the BDNF Val66Met are also discussed with respect to future research.
AbstractList Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development, differentiation, and survival in the developing and adult nervous system. A common single-nucleotide polymorphism in the pro-region of the human BDNF gene, resulting in a valine to methionine substitution (Val66Met), has been associated with the susceptibility, incidence, and clinical features of several neurodegenerative disorders. Much research has been dedicated to evaluating the effects of polymorphism in the past decade, and functional effects of this genetic variation. A better understanding of how this naturally occurring polymorphism associates with or influences physiology, anatomy, and cognition in both healthy and diseased adults in neurodegenerative conditions will help understand neurochemical mechanisms and definable clinical outcomes in humans. Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer’s disease (AD) and Parkinson’s disease (PD). Several controversies and unresolved issues, including small effect sizes, possible ethnicity, gender, and age effects of the BDNF Val66Met are also discussed with respect to future research.
Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development, differentiation, and survival in the developing and adult nervous system. A common single-nucleotide polymorphism in the pro-region of the human BDNF gene, resulting in a valine to methionine substitution (Val66Met), has been associated with the susceptibility, incidence, and clinical features of several neurodegenerative disorders. Much research has been dedicated to evaluating the effects of polymorphism in the past decade, and functional effects of this genetic variation. A better understanding of how this naturally occurring polymorphism associates with or influences physiology, anatomy, and cognition in both healthy and diseased adults in neurodegenerative conditions will help understand neurochemical mechanisms and definable clinical outcomes in humans. Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). Several controversies and unresolved issues, including small effect sizes, possible ethnicity, gender, and age effects of the BDNF Val66Met are also discussed with respect to future research. Key words: BDNF, polymorphism, neurodegenerative diseases, glaucoma, multiple sclerosis, Alzheimer's disease
Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development, differentiation, and survival in the developing and adult nervous system. A common single-nucleotide polymorphism in the pro-region of the human BDNF gene, resulting in a valine to methionine substitution (Val66Met), has been associated with the susceptibility, incidence, and clinical features of several neurodegenerative disorders. Much research has been dedicated to evaluating the effects of polymorphism in the past decade, and functional effects of this genetic variation. A better understanding of how this naturally occurring polymorphism associates with or influences physiology, anatomy, and cognition in both healthy and diseased adults in neurodegenerative conditions will help understand neurochemical mechanisms and definable clinical outcomes in humans. Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). Several controversies and unresolved issues, including small effect sizes, possible ethnicity, gender, and age effects of the BDNF Val66Met are also discussed with respect to future research.Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development, differentiation, and survival in the developing and adult nervous system. A common single-nucleotide polymorphism in the pro-region of the human BDNF gene, resulting in a valine to methionine substitution (Val66Met), has been associated with the susceptibility, incidence, and clinical features of several neurodegenerative disorders. Much research has been dedicated to evaluating the effects of polymorphism in the past decade, and functional effects of this genetic variation. A better understanding of how this naturally occurring polymorphism associates with or influences physiology, anatomy, and cognition in both healthy and diseased adults in neurodegenerative conditions will help understand neurochemical mechanisms and definable clinical outcomes in humans. Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). Several controversies and unresolved issues, including small effect sizes, possible ethnicity, gender, and age effects of the BDNF Val66Met are also discussed with respect to future research.
Audience Academic
Author Shen, Ting
Mirzaei, Mehdi
Graham, Stuart L.
You, Yuyi
Klistorner, Alexander
Gupta, Vivek
Joseph, Chitra
AuthorAffiliation 2 Save Sight Institute, Sydney University, Sydney, Australia
3 Faculty of Science and Engineering, Macquarie University, Australia
1 Faculty of Medicine and Health Sciences, Macquarie University, Australia
AuthorAffiliation_xml – name: 1 Faculty of Medicine and Health Sciences, Macquarie University, Australia
– name: 3 Faculty of Science and Engineering, Macquarie University, Australia
– name: 2 Save Sight Institute, Sydney University, Sydney, Australia
Author_xml – sequence: 1
  givenname: Ting
  surname: Shen
  fullname: Shen, Ting
– sequence: 2
  givenname: Yuyi
  surname: You
  fullname: You, Yuyi
– sequence: 3
  givenname: Chitra
  surname: Joseph
  fullname: Joseph, Chitra
– sequence: 4
  givenname: Mehdi
  surname: Mirzaei
  fullname: Mirzaei, Mehdi
– sequence: 5
  givenname: Alexander
  surname: Klistorner
  fullname: Klistorner, Alexander
– sequence: 6
  givenname: Stuart L.
  surname: Graham
  fullname: Graham, Stuart L.
– sequence: 7
  givenname: Vivek
  surname: Gupta
  fullname: Gupta, Vivek
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29896439$$D View this record in MEDLINE/PubMed
BookMark eNp1ksGPEyEUxidmjbuue_RqJjExXloHKNDxYFJbVzfZrMbombyBR4thoAvTmv3vpXbdtEbhAIHf98HL-55WJyEGrKrnpBmTCWPizWwxpg2R40YS-ag6o4TTEae8OTnYn1YXOf9oymAtZS17Up3SdtqKCWvPKv1-cXNZf4n-ro9pvXK5f1vP6q-4dfizjra-GnK9cLAMMQ9O1xBMPfcuOA2-UB63EDTWLtQ3uEnR4BIDJhjcFossx2Qw5WfVYws-48X9el59v_zwbf5pdP3549V8dj3SnJNhpDtCAbjtOgNsYo0wAqS1rWmsACFpN5XQddhxiZZxQoSxsmVGak0NwJSx8-rd3ne96Xo0GsOQwKt1cj2kOxXBqeOb4FZqGbeKt9OpaEQxeH1vkOLtBvOgepc1eg8B4yYr2vBJSyVpJwV9uUeX4FG5YGNx1DtczTgXRArBZaHG_6DKNNg7XXppXTk_Erw6EKwQ_LDK0W8GF0M-Bl8c1vpQ5J_OFmC0B3SKOSe0Dwhp1O_wqNlC7cKjduEpPPuL126A3bvly87_R_ULcofGug
CitedBy_id crossref_primary_10_1167_iovs_18_26364
crossref_primary_10_1371_journal_pone_0291397
crossref_primary_10_1007_s00441_020_03253_2
crossref_primary_10_3389_fphys_2023_1102526
crossref_primary_10_1097_MD_0000000000028910
crossref_primary_10_1186_s13568_024_01664_w
crossref_primary_10_1097_MD_0000000000029481
crossref_primary_10_1186_s12885_025_14430_3
crossref_primary_10_3389_fnins_2019_01236
crossref_primary_10_3390_genes13020332
crossref_primary_10_3390_ijms23158417
crossref_primary_10_7759_cureus_74048
crossref_primary_10_1016_j_taap_2019_114673
crossref_primary_10_3390_ijms22041758
crossref_primary_10_1080_1028415X_2023_2245996
crossref_primary_10_3389_fphys_2021_686838
crossref_primary_10_1186_s13568_023_01640_w
crossref_primary_10_1038_s41531_024_00771_6
crossref_primary_10_19163_2307_9266_2025_13_1_4_19
crossref_primary_10_1177_02698811211032609
crossref_primary_10_3390_genes13081336
crossref_primary_10_3390_ijms23148011
crossref_primary_10_1007_s10517_019_04574_1
crossref_primary_10_1007_s12311_021_01313_z
crossref_primary_10_3390_genes15020240
crossref_primary_10_15446_revfacmed_v69n3_80142
crossref_primary_10_3233_JAD_180853
crossref_primary_10_3390_life15020213
crossref_primary_10_1177_1178646920978243
crossref_primary_10_1167_iovs_64_12_9
crossref_primary_10_3390_genes14122130
crossref_primary_10_1038_s41598_020_77210_y
crossref_primary_10_3389_fgene_2018_00583
crossref_primary_10_3389_fphar_2020_00077
crossref_primary_10_1016_j_neulet_2022_136478
crossref_primary_10_1007_s10072_023_07173_1
crossref_primary_10_1016_j_jad_2021_10_077
crossref_primary_10_3389_fnmol_2021_638176
crossref_primary_10_1016_j_bbr_2021_113712
crossref_primary_10_1177_11206721251335060
crossref_primary_10_1016_j_jsbmb_2023_106356
crossref_primary_10_1016_j_nicl_2023_103329
crossref_primary_10_1007_s12035_021_02627_z
crossref_primary_10_1080_01616412_2021_1922181
crossref_primary_10_1016_j_neulet_2019_134653
crossref_primary_10_3233_JAD_190738
crossref_primary_10_3390_ijms22073582
crossref_primary_10_1016_j_janxdis_2020_102223
crossref_primary_10_3390_ijms26188987
crossref_primary_10_1007_s11064_019_02910_5
crossref_primary_10_3389_fendo_2024_1417292
crossref_primary_10_1038_s41531_024_00803_1
crossref_primary_10_1016_j_envres_2021_110727
crossref_primary_10_3390_ijms232314599
crossref_primary_10_1016_j_phrs_2020_105281
crossref_primary_10_3389_fpsyg_2024_1386233
crossref_primary_10_4103_1673_5374_343894
crossref_primary_10_1155_2019_3124295
crossref_primary_10_1016_j_expneurol_2021_113891
crossref_primary_10_1111_gbb_12724
crossref_primary_10_1016_j_blre_2021_100871
crossref_primary_10_1186_s12888_021_03081_w
crossref_primary_10_14814_phy2_16140
crossref_primary_10_1016_j_bios_2025_117837
crossref_primary_10_3390_ijms21186524
crossref_primary_10_1155_2021_7117613
crossref_primary_10_3389_fneur_2024_1385042
crossref_primary_10_3389_fpsyt_2022_1022442
crossref_primary_10_1152_jn_00268_2021
crossref_primary_10_3389_fnagi_2023_1244191
crossref_primary_10_3390_genes13030482
crossref_primary_10_3390_diagnostics10090684
crossref_primary_10_3390_jpm13091395
crossref_primary_10_1093_arclin_acae014
crossref_primary_10_1016_j_jneuroim_2020_577406
crossref_primary_10_1016_j_pnpbp_2019_109657
crossref_primary_10_1016_j_msard_2021_103033
crossref_primary_10_1186_s40035_023_00341_5
crossref_primary_10_3389_fnins_2021_715330
crossref_primary_10_1016_j_preteyeres_2020_100899
crossref_primary_10_3389_fphys_2025_1568334
crossref_primary_10_1016_j_brainres_2020_146652
crossref_primary_10_1016_j_neulet_2019_05_002
crossref_primary_10_1080_13854046_2020_1740324
crossref_primary_10_1089_ars_2020_8075
crossref_primary_10_1097_YCT_0000000000001123
crossref_primary_10_1016_j_bbr_2020_113081
crossref_primary_10_1016_j_biochi_2019_02_011
crossref_primary_10_1016_j_bbr_2019_112039
crossref_primary_10_1186_s42358_021_00183_7
Cites_doi 10.1159/000075332
10.1002/ajmg.b.30986
10.1002/(SICI)1096-9861(19970915)386:1<149::AID-CNE13>3.0.CO;2-F
10.1016/j.bbadis.2014.05.026
10.1001/archgenpsychiatry.2010.194
10.1523/JNEUROSCI.12-11-04391.1992
10.1002/ana.10585
10.1007/s100720170011
10.1038/ng.2390
10.1016/j.jneuroim.2005.06.008
10.1006/bbrc.1999.1561
10.1212/01.wnl.0000187075.81589.fd
10.1007/s00415-005-0667-5
10.1126/science.7638622
10.3389/fneur.2017.00159
10.1038/381706a0
10.1016/j.ygeno.2007.05.004
10.1523/JNEUROSCI.2680-04.2004
10.1093/brain/awh624
10.1002/ajmg.b.30332
10.3325/cmj.2009.50.43
10.1007/s00702-004-0210-3
10.1016/j.brainresbull.2009.06.022
10.1371/journal.pone.0086498
10.1016/0888-7543(91)90436-I
10.1016/0304-3940(94)11123-Z
10.1038/ng.396
10.1016/j.biopsych.2005.09.022
10.3758/CABN.6.1.79
10.1136/bjo.2005.081224
10.1002/ana.10842
10.1016/j.pnpbp.2011.02.009
10.1017/S0317167100047351
10.1016/S0092-8674(03)00035-7
10.2165/11595870-000000000-00000
10.1038/349704a0
10.1016/j.neuropsychologia.2012.09.042
10.1002/ajmg.b.30154
10.1152/physrev.2001.81.2.741
10.1016/j.pathophys.2010.04.006
10.1016/j.neulet.2005.11.032
10.1007/s10072-010-0433-z
10.1016/j.preteyeres.2010.02.001
10.1002/ajmg.b.30476
10.1016/j.pnpbp.2008.03.014
10.1097/YPG.0b013e32833a2038
10.1038/sj.mp.4000792
10.1001/archneur.57.6.846
10.1093/hmg/ddr120
10.1523/JNEUROSCI.3501-13.2014
10.5114/aoms.2014.45089
10.55782/ane-2010-1816
10.1371/journal.pone.0115579
10.1002/ana.10079
10.1111/j.1600-0404.2009.01253.x
10.1073/pnas.92.19.8856
10.1016/j.jneuroim.2007.10.013
10.1038/361031a0
10.1002/mds.20491
10.1111/ene.12913
10.1016/j.neulet.2003.09.009
10.1371/journal.pone.0061063
10.1038/mp.2015.27
10.1007/s00415-005-0756-5
10.1007/s00415-009-5357-2
10.1056/NEJMoa073493
10.1016/j.neurobiolaging.2005.10.013
10.1016/S1474-4422(03)00308-9
10.1016/j.neuroimage.2012.08.079
10.1126/science.1129663
10.1136/jnnp.2008.154294
10.1016/j.neulet.2005.02.017
10.1159/000336997
10.1073/pnas.91.5.1632
10.1038/nature02621
10.1093/brain/aww200
10.1016/j.jocn.2011.03.015
10.1056/NEJM199304153281507
10.1111/j.1601-183X.2007.00363.x
10.1074/jbc.M008104200
10.1038/mp.2009.24
10.1126/science.2321006
10.1016/j.neulet.2006.12.038
10.1006/exnr.2000.7483
10.1126/science.275.5300.668
10.1016/j.brainres.2008.11.047
10.1016/j.neulet.2016.01.030
10.1159/000077736
10.1002/ajmg.b.20118
10.1101/gr.8.8.769
10.1212/WNL.0000000000000768
10.1038/376775a0
10.1016/j.neurobiolaging.2013.05.006
10.1016/j.parkreldis.2003.12.003
10.1371/journal.pone.0010003
10.1016/0896-6273(91)90273-3
10.1016/j.neulet.2013.12.051
10.1111/j.1468-1331.2009.02706.x
10.1016/j.expneurol.2005.01.026
10.1007/s00406-011-0189-3
10.1016/j.jalz.2007.04.381
10.1016/j.neurobiolaging.2014.08.023
10.1242/jcs.033316
10.1515/CCLM.2011.039
10.1016/S0006-3223(03)00181-1
10.1016/j.bbr.2009.10.022
10.1093/hmg/ddm189
10.1016/j.pathophys.2010.04.005
10.1176/appi.ajp.161.11.1957
10.1038/sj.tpj.6500094
10.1038/sj.mp.4000952
10.1016/S0006-8993(00)02237-X
10.1098/rstb.2006.1894
10.1016/j.jneuroim.2012.01.011
10.1038/mp.2008.80
10.1038/sj.mp.4001799
10.1093/cercor/bhw020
10.1002/ana.10487
10.1093/emboj/16.16.4999
10.1111/j.1601-183X.2006.00245.x
10.1146/annurev.genom.2.1.235
10.1111/j.1468-1331.2011.03529.x
10.1016/S0304-3940(01)01830-4
10.1006/exnr.2002.7869
10.1016/j.neulet.2005.07.009
10.1167/iovs.02-1332
10.1016/j.pharmthera.2013.01.004
10.1016/S0304-3940(99)00463-2
10.3389/neuro.09.011.2008
10.1126/science.1066901
ContentType Journal Article
Copyright COPYRIGHT 2018 JKL International
Copyright: © 2018 Shen et al. 2018
Copyright_xml – notice: COPYRIGHT 2018 JKL International
– notice: Copyright: © 2018 Shen et al. 2018
DBID AAYXX
CITATION
NPM
7X8
5PM
DOI 10.14336/AD.2017.0717
DatabaseName CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList
PubMed


MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 2152-5250
EndPage 536
ExternalDocumentID PMC5988606
A556176657
29896439
10_14336_AD_2017_0717
Genre Journal Article
Review
GroupedDBID 53G
5VS
AAYXX
ABDBF
ACUHS
ADBBV
AENEX
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
C1A
CITATION
DIK
EBD
ESX
GROUPED_DOAJ
HYE
IAO
IHR
IHW
ITC
KQ8
M~E
OK1
RPM
TUS
NPM
7X8
5PM
ID FETCH-LOGICAL-c551t-cb12aa5fbbda34fd6d6a7ff9d0f6a672b87abbeb57ef35116df793d7cc2daa833
ISICitedReferencesCount 110
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000434762200017&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2152-5250
IngestDate Thu Aug 21 13:37:29 EDT 2025
Fri Jul 11 09:25:15 EDT 2025
Wed Mar 19 01:50:54 EDT 2025
Sat Mar 08 18:13:57 EST 2025
Thu May 22 21:21:37 EDT 2025
Wed Feb 19 02:43:01 EST 2025
Tue Nov 18 22:05:31 EST 2025
Sat Nov 29 06:32:53 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords neurodegenerative diseases
polymorphism
Alzheimer’s disease
BDNF
glaucoma
multiple sclerosis
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c551t-cb12aa5fbbda34fd6d6a7ff9d0f6a672b87abbeb57ef35116df793d7cc2daa833
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
OpenAccessLink http://dx.doi.org/10.14336/AD.2017.0717
PMID 29896439
PQID 2054927194
PQPubID 23479
PageCount 14
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5988606
proquest_miscellaneous_2054927194
gale_infotracmisc_A556176657
gale_infotracacademiconefile_A556176657
gale_healthsolutions_A556176657
pubmed_primary_29896439
crossref_primary_10_14336_AD_2017_0717
crossref_citationtrail_10_14336_AD_2017_0717
PublicationCentury 2000
PublicationDate 2018-06-01
PublicationDateYYYYMMDD 2018-06-01
PublicationDate_xml – month: 06
  year: 2018
  text: 2018-06-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Aging and disease
PublicationTitleAlternate Aging Dis
PublicationYear 2018
Publisher JKL International
JKL International LLC
Publisher_xml – name: JKL International
– name: JKL International LLC
References key-10.14336/AD.2017.0717-50
key-10.14336/AD.2017.0717-49
key-10.14336/AD.2017.0717-48
key-10.14336/AD.2017.0717-45
key-10.14336/AD.2017.0717-44
key-10.14336/AD.2017.0717-47
key-10.14336/AD.2017.0717-46
key-10.14336/AD.2017.0717-41
key-10.14336/AD.2017.0717-40
key-10.14336/AD.2017.0717-43
key-10.14336/AD.2017.0717-42
key-10.14336/AD.2017.0717-3
key-10.14336/AD.2017.0717-2
key-10.14336/AD.2017.0717-1
key-10.14336/AD.2017.0717-38
key-10.14336/AD.2017.0717-37
key-10.14336/AD.2017.0717-39
key-10.14336/AD.2017.0717-7
key-10.14336/AD.2017.0717-34
key-10.14336/AD.2017.0717-6
key-10.14336/AD.2017.0717-33
key-10.14336/AD.2017.0717-5
key-10.14336/AD.2017.0717-36
key-10.14336/AD.2017.0717-4
key-10.14336/AD.2017.0717-35
key-10.14336/AD.2017.0717-30
key-10.14336/AD.2017.0717-9
key-10.14336/AD.2017.0717-32
key-10.14336/AD.2017.0717-8
key-10.14336/AD.2017.0717-31
key-10.14336/AD.2017.0717-70
key-10.14336/AD.2017.0717-72
key-10.14336/AD.2017.0717-71
key-10.14336/AD.2017.0717-67
key-10.14336/AD.2017.0717-135
key-10.14336/AD.2017.0717-66
key-10.14336/AD.2017.0717-134
key-10.14336/AD.2017.0717-69
key-10.14336/AD.2017.0717-133
key-10.14336/AD.2017.0717-68
key-10.14336/AD.2017.0717-132
key-10.14336/AD.2017.0717-63
key-10.14336/AD.2017.0717-131
key-10.14336/AD.2017.0717-62
key-10.14336/AD.2017.0717-130
key-10.14336/AD.2017.0717-65
key-10.14336/AD.2017.0717-64
key-10.14336/AD.2017.0717-61
key-10.14336/AD.2017.0717-60
key-10.14336/AD.2017.0717-129
key-10.14336/AD.2017.0717-128
key-10.14336/AD.2017.0717-127
key-10.14336/AD.2017.0717-126
key-10.14336/AD.2017.0717-125
key-10.14336/AD.2017.0717-59
key-10.14336/AD.2017.0717-56
key-10.14336/AD.2017.0717-124
key-10.14336/AD.2017.0717-55
key-10.14336/AD.2017.0717-123
key-10.14336/AD.2017.0717-58
key-10.14336/AD.2017.0717-122
key-10.14336/AD.2017.0717-57
key-10.14336/AD.2017.0717-121
key-10.14336/AD.2017.0717-52
key-10.14336/AD.2017.0717-120
key-10.14336/AD.2017.0717-51
key-10.14336/AD.2017.0717-54
key-10.14336/AD.2017.0717-53
key-10.14336/AD.2017.0717-92
key-10.14336/AD.2017.0717-91
key-10.14336/AD.2017.0717-94
key-10.14336/AD.2017.0717-119
key-10.14336/AD.2017.0717-93
key-10.14336/AD.2017.0717-118
key-10.14336/AD.2017.0717-117
key-10.14336/AD.2017.0717-116
key-10.14336/AD.2017.0717-90
key-10.14336/AD.2017.0717-115
key-10.14336/AD.2017.0717-114
key-10.14336/AD.2017.0717-89
key-10.14336/AD.2017.0717-113
key-10.14336/AD.2017.0717-88
key-10.14336/AD.2017.0717-112
key-10.14336/AD.2017.0717-111
key-10.14336/AD.2017.0717-110
key-10.14336/AD.2017.0717-85
key-10.14336/AD.2017.0717-84
key-10.14336/AD.2017.0717-87
key-10.14336/AD.2017.0717-86
key-10.14336/AD.2017.0717-81
key-10.14336/AD.2017.0717-80
key-10.14336/AD.2017.0717-109
key-10.14336/AD.2017.0717-83
key-10.14336/AD.2017.0717-108
key-10.14336/AD.2017.0717-82
key-10.14336/AD.2017.0717-107
key-10.14336/AD.2017.0717-106
key-10.14336/AD.2017.0717-105
key-10.14336/AD.2017.0717-104
key-10.14336/AD.2017.0717-103
key-10.14336/AD.2017.0717-78
key-10.14336/AD.2017.0717-102
key-10.14336/AD.2017.0717-77
key-10.14336/AD.2017.0717-101
key-10.14336/AD.2017.0717-100
key-10.14336/AD.2017.0717-79
key-10.14336/AD.2017.0717-74
key-10.14336/AD.2017.0717-73
key-10.14336/AD.2017.0717-76
key-10.14336/AD.2017.0717-75
key-10.14336/AD.2017.0717-27
key-10.14336/AD.2017.0717-26
key-10.14336/AD.2017.0717-29
key-10.14336/AD.2017.0717-28
key-10.14336/AD.2017.0717-23
key-10.14336/AD.2017.0717-22
key-10.14336/AD.2017.0717-25
key-10.14336/AD.2017.0717-24
key-10.14336/AD.2017.0717-21
key-10.14336/AD.2017.0717-20
key-10.14336/AD.2017.0717-19
key-10.14336/AD.2017.0717-16
key-10.14336/AD.2017.0717-15
key-10.14336/AD.2017.0717-18
key-10.14336/AD.2017.0717-17
key-10.14336/AD.2017.0717-12
key-10.14336/AD.2017.0717-11
key-10.14336/AD.2017.0717-99
key-10.14336/AD.2017.0717-14
key-10.14336/AD.2017.0717-13
key-10.14336/AD.2017.0717-96
key-10.14336/AD.2017.0717-95
key-10.14336/AD.2017.0717-10
key-10.14336/AD.2017.0717-98
key-10.14336/AD.2017.0717-97
15772739 - J Neurol. 2005 Jul;252(7):833-8
18977816 - J Neurol Neurosurg Psychiatry. 2009 Feb;80(2):141-4
19156154 - Mol Psychiatry. 2009 Feb;14(2):120-2
19874854 - Behav Brain Res. 2010 Mar 5;207(2):377-86
19050044 - J Cell Sci. 2009 Jan 1;122(Pt 1):36-43
19538209 - Eur J Neurol. 2009 Nov;16(11):1240-5
16442082 - Biol Psychiatry. 2006 May 1;59(9):812-5
11922662 - Exp Neurol. 2002 Apr;174(2):201-14
11274073 - Invest Ophthalmol Vis Sci. 2001 Apr;42(5):966-74
19847468 - J Neurol. 2010 Apr;257(4):540-5
11840305 - Mol Psychiatry. 2002;7(2):136-7
25444596 - Neurobiol Aging. 2015 Mar;36(3):1605.e1-6
16446742 - Mol Psychiatry. 2006 May;11(5):505-13
11701650 - Annu Rev Genomics Hum Genet. 2001;2:235-58
16488940 - Br J Ophthalmol. 2006 Mar;90(3):262-7
15635706 - Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):1-5
1742020 - Neuron. 1991 Nov;7(5):695-702
17023662 - Science. 2006 Oct 6;314(5796):140-3
26806863 - Neurosci Lett. 2016 Feb 26;615:88-91
17427185 - Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):458-62
21196952 - Acta Neurobiol Exp (Wars). 2010;70(4):454-67
24942931 - Biochim Biophys Acta. 2014 Sep;1842(9):1567-78
21967235 - Eur J Neurol. 2012 Apr;19(4):655-9
20400928 - Psychiatr Genet. 2010 Jun;20(3):109-12
28507530 - Front Neurol. 2017 May 01;8:159
10454142 - Neurosci Lett. 1999 Jul 23;270(1):45-8
18061279 - J Neuroimmunol. 2008 Jan;193(1-2):170-2
1432101 - J Neurosci. 1992 Nov;12(11):4391-402
24523553 - J Neurosci. 2014 Feb 12;34(7):2645-51
2321006 - Science. 1990 Mar 23;247(4949 Pt 1):1446-51
15726264 - J Neurol. 2005 Apr;252(4):423-8
23593393 - PLoS One. 2013 Apr 11;8(4):e61063
11376903 - Neurosci Lett. 2001 Jun 8;305(2):139-42
23769397 - Neurobiol Aging. 2013 Nov;34(11):2457-64
21143020 - Clin Chem Lab Med. 2011 Feb;49(2):185-9
17229524 - Neurosci Lett. 2007 Mar 19;415(1):59-63
16344533 - Neurology. 2005 Dec 13;65(11):1823-5
15048661 - Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):122-3
21290143 - Eur Arch Psychiatry Clin Neurosci. 2011 Aug;261(5):323-9
21985169 - Drugs. 2011 Oct 22;71(15):2031-65
8421494 - Nature. 1993 Jan 7;361(6407):31-9
7568031 - Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8856-60
1671712 - Nature. 1991 Feb 21;349(6311):704-6
11782995 - Ann Neurol. 2002 Jan;51(1):133-6
20478698 - Pathophysiology. 2011 Feb;18(1):53-60
17656372 - Hum Mol Genet. 2007 Nov 15;16(22):2659-68
12783434 - Ann Neurol. 2003 Jun;53(6):823
12049172 - Pharmacogenomics J. 2002;2(2):103-10
16046000 - J Neuroimmunol. 2005 Oct;167(1-2):183-5
20953813 - Neurol Sci. 2011 Feb;32(1):117-23
8455668 - N Engl J Med. 1993 Apr 15;328(15):1097-106
15537879 - J Neurosci. 2004 Nov 10;24(45):10099-102
17629449 - Genomics. 2007 Sep;90(3):397-406
16054753 - Neurosci Lett. 2005 Oct 14;387(1):11-6
16740142 - Genes Brain Behav. 2007 Mar;6(2):177-83
16356643 - Neurosci Lett. 2006 Apr 3;396(3):217-9
15838855 - Mov Disord. 2005 Aug;20(8):1031-3
8127857 - Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1632-6
9303531 - J Comp Neurol. 1997 Sep 15;386(1):149-60
25536045 - PLoS One. 2014 Dec 23;9(12):e115579
19595937 - Alzheimers Dement. 2007 Jul;3(3):186-91
14730194 - Neuropsychobiology. 2004;49(1):10-2
19504537 - Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):235-42
25824305 - Mol Psychiatry. 2015 Aug;20(8):916-30
12666095 - Ann Neurol. 2003;53 Suppl 3:S16-23; discussion S23-5
10711692 - Invest Ophthalmol Vis Sci. 2000 Mar;41(3):764-74
15571060 - Am Fam Physician. 2004 Nov 15;70(10):1935-44
16869232 - Cogn Affect Behav Neurosci. 2006 Mar;6(1):79-85
20547043 - Pathophysiology. 2011 Feb;18(1):43-52
12842310 - Biol Psychiatry. 2003 Jul 1;54(1):70-5
16565926 - Folia Neuropathol. 2006;44(1):12-6
25200713 - Neurology. 2014 Sep 9;83(11):1022-4
8467424 - Can J Neurol Sci. 1993 Feb;20(1):17-29
15375678 - J Neural Transm (Vienna). 2005 May;112(5):703-11
11834836 - Science. 2002 Feb 8;295(5557):1077-9
9724323 - Genome Res. 1998 Aug;8(8):769-76
9005853 - Science. 1997 Jan 31;275(5300):668-70
19260143 - Croat Med J. 2009 Feb;50(1):43-8
21427129 - Hum Mol Genet. 2011 Jun 15;20(12):2464-71
14507880 - Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4357-65
18472202 - Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1236-42
27521573 - Brain. 2016 Oct;139(Pt 10):2766-2777
14991827 - Ann Neurol. 2004 Mar;55(3):447-8
24394906 - Neurosci Lett. 2014 Feb 21;561:86-90
19589373 - Brain Res Bull. 2010 Jan 15;81(1):61-5
15514393 - Am J Psychiatry. 2004 Nov;161(11):1957-66
11152678 - J Biol Chem. 2001 Apr 20;276(16):12660-6
16649215 - Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):387-93
18958211 - Front Hum Neurosci. 2008 Sep 23;2:11
26830347 - Cereb Cortex. 2016 Apr;26(4):1795-803
20368992 - PLoS One. 2010 Apr 02;5(4):e10003
15896483 - Neurosci Lett. 2005 Jun 24;381(3):275-8
26756166 - Eur J Neurol. 2016 Mar;23 (3):630-40
10825501 - Brain Res. 2000 Jun 2;866(1-2):257-61
20085561 - Acta Neurol Scand. 2010 Jul;122(1):41-5
12553913 - Cell. 2003 Jan 24;112(2):257-69
23348013 - Pharmacol Ther. 2013 May;138(2):155-75
7638622 - Science. 1995 Aug 18;269(5226):973-7
22341604 - J Neuroimmunol. 2012 Mar;244(1-2):107-10
14642442 - Neurosci Lett. 2003 Dec 15;353(1):75-7
16183661 - Brain. 2005 Dec;128(Pt 12):2899-910
19255578 - Mol Psychiatry. 2010 Aug;15(8):810-5
8649517 - Nature. 1996 Jun 20;381(6584):706-9
19071096 - Brain Res. 2009 Feb 23;1256:123-8
23041465 - Neuropsychologia. 2012 Dec;50(14):3554-63
11274343 - Physiol Rev. 2001 Apr;81(2):741-66
19525955 - Nat Genet. 2009 Jul;41(7):824-8
22922875 - Nat Genet. 2012 Oct;44(10 ):1142-1146
17660530 - N Engl J Med. 2007 Aug 30;357(9):851-62
22001244 - J Clin Neurosci. 2011 Dec;18(12):1744-5
24475133 - PLoS One. 2014 Jan 27;9(1):e86498
11603614 - Neurol Sci. 2001 Apr;22(2):117-39
12849268 - Lancet Neurol. 2003 Feb;2(2):117-27
7651536 - Nature. 1995 Aug 31;376(6543):775-8
22963854 - Neuroimage. 2013 Jan 1;64:290-8
22538247 - Neuropsychobiology. 2012 Jun;65(4):183-7
15120095 - Parkinsonism Relat Disord. 2004 Jun;10(4):213-9
1889806 - Genomics. 1991 Jul;10(3):558-68
10867782 - Arch Neurol. 2000 Jun;57(6):846-51
21338649 - Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):1022-5
7746496 - Neurosci Lett. 1995 Jan 2;183(1-2):96-9
16939974 - Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1545-64
17973920 - Genes Brain Behav. 2008 Jun;7(4):411-7
9305641 - EMBO J. 1997 Aug 15;16(16):4999-5005
21300947 - Arch Gen Psychiatry. 2011 Feb;68(2):198-206
15295589 - Nature. 2004 Aug 5;430(7000):631-9
11244490 - Mol Psychiatry. 2001 Jan;6(1):83-6
15899246 - Exp Neurol. 2005 Jul;194(1):91-6
15084795 - Dement Geriatr Cogn Disord. 2004;18(1):55-8
11031089 - Exp Neurol. 2000 Nov;166(1):127-35
25624860 - Arch Med Sci. 2014 Dec 22;10(6):1206-13
16343697 - Neurobiol Aging. 2006 Dec;27(12):1834-7
20226873 - Prog Retin Eye Res. 2010 Jul;29(4):249-71
10543986 - Biochem Biophys Res Commun. 1999 Nov 2;264(3):648-51
References_xml – ident: key-10.14336/AD.2017.0717-104
  doi: 10.1159/000075332
– ident: key-10.14336/AD.2017.0717-41
  doi: 10.1002/ajmg.b.30986
– ident: key-10.14336/AD.2017.0717-65
  doi: 10.1002/(SICI)1096-9861(19970915)386:1<149::AID-CNE13>3.0.CO;2-F
– ident: key-10.14336/AD.2017.0717-69
  doi: 10.1016/j.bbadis.2014.05.026
– ident: key-10.14336/AD.2017.0717-131
  doi: 10.1001/archgenpsychiatry.2010.194
– ident: key-10.14336/AD.2017.0717-18
  doi: 10.1523/JNEUROSCI.12-11-04391.1992
– ident: key-10.14336/AD.2017.0717-120
  doi: 10.1002/ana.10585
– ident: key-10.14336/AD.2017.0717-89
  doi: 10.1007/s100720170011
– ident: key-10.14336/AD.2017.0717-19
– ident: key-10.14336/AD.2017.0717-63
  doi: 10.1038/ng.2390
– ident: key-10.14336/AD.2017.0717-86
  doi: 10.1016/j.jneuroim.2005.06.008
– ident: key-10.14336/AD.2017.0717-8
  doi: 10.1006/bbrc.1999.1561
– ident: key-10.14336/AD.2017.0717-114
  doi: 10.1212/01.wnl.0000187075.81589.fd
– ident: key-10.14336/AD.2017.0717-75
– ident: key-10.14336/AD.2017.0717-42
  doi: 10.1007/s00415-005-0667-5
– ident: key-10.14336/AD.2017.0717-98
  doi: 10.1126/science.7638622
– ident: key-10.14336/AD.2017.0717-30
  doi: 10.3389/fneur.2017.00159
– ident: key-10.14336/AD.2017.0717-14
  doi: 10.1038/381706a0
– ident: key-10.14336/AD.2017.0717-21
  doi: 10.1016/j.ygeno.2007.05.004
– ident: key-10.14336/AD.2017.0717-53
  doi: 10.1523/JNEUROSCI.2680-04.2004
– ident: key-10.14336/AD.2017.0717-91
  doi: 10.1093/brain/awh624
– ident: key-10.14336/AD.2017.0717-34
  doi: 10.1002/ajmg.b.30332
– ident: key-10.14336/AD.2017.0717-33
  doi: 10.3325/cmj.2009.50.43
– ident: key-10.14336/AD.2017.0717-43
  doi: 10.1007/s00702-004-0210-3
– ident: key-10.14336/AD.2017.0717-49
  doi: 10.1016/j.brainresbull.2009.06.022
– ident: key-10.14336/AD.2017.0717-100
  doi: 10.1371/journal.pone.0086498
– ident: key-10.14336/AD.2017.0717-4
  doi: 10.1016/0888-7543(91)90436-I
– ident: key-10.14336/AD.2017.0717-64
  doi: 10.1016/0304-3940(94)11123-Z
– ident: key-10.14336/AD.2017.0717-77
  doi: 10.1038/ng.396
– ident: key-10.14336/AD.2017.0717-133
  doi: 10.1016/j.biopsych.2005.09.022
– ident: key-10.14336/AD.2017.0717-31
  doi: 10.3758/CABN.6.1.79
– ident: key-10.14336/AD.2017.0717-59
  doi: 10.1136/bjo.2005.081224
– ident: key-10.14336/AD.2017.0717-106
  doi: 10.1002/ana.10842
– ident: key-10.14336/AD.2017.0717-51
  doi: 10.1016/j.pnpbp.2011.02.009
– ident: key-10.14336/AD.2017.0717-88
  doi: 10.1017/S0317167100047351
– ident: key-10.14336/AD.2017.0717-1
  doi: 10.1016/S0092-8674(03)00035-7
– ident: key-10.14336/AD.2017.0717-95
  doi: 10.2165/11595870-000000000-00000
– ident: key-10.14336/AD.2017.0717-96
  doi: 10.1038/349704a0
– ident: key-10.14336/AD.2017.0717-129
  doi: 10.1016/j.neuropsychologia.2012.09.042
– ident: key-10.14336/AD.2017.0717-40
  doi: 10.1002/ajmg.b.30154
– ident: key-10.14336/AD.2017.0717-99
  doi: 10.1152/physrev.2001.81.2.741
– ident: key-10.14336/AD.2017.0717-81
  doi: 10.1016/j.pathophys.2010.04.006
– ident: key-10.14336/AD.2017.0717-87
  doi: 10.1016/j.neulet.2005.11.032
– ident: key-10.14336/AD.2017.0717-83
  doi: 10.1007/s10072-010-0433-z
– ident: key-10.14336/AD.2017.0717-58
  doi: 10.1016/j.preteyeres.2010.02.001
– ident: key-10.14336/AD.2017.0717-122
  doi: 10.1002/ajmg.b.30476
– ident: key-10.14336/AD.2017.0717-134
  doi: 10.1016/j.pnpbp.2008.03.014
– ident: key-10.14336/AD.2017.0717-25
  doi: 10.1097/YPG.0b013e32833a2038
– ident: key-10.14336/AD.2017.0717-108
  doi: 10.1038/sj.mp.4000792
– ident: key-10.14336/AD.2017.0717-7
  doi: 10.1001/archneur.57.6.846
– ident: key-10.14336/AD.2017.0717-62
  doi: 10.1093/hmg/ddr120
– ident: key-10.14336/AD.2017.0717-135
  doi: 10.1523/JNEUROSCI.3501-13.2014
– ident: key-10.14336/AD.2017.0717-72
  doi: 10.5114/aoms.2014.45089
– ident: key-10.14336/AD.2017.0717-66
– ident: key-10.14336/AD.2017.0717-17
  doi: 10.55782/ane-2010-1816
– ident: key-10.14336/AD.2017.0717-70
  doi: 10.1371/journal.pone.0115579
– ident: key-10.14336/AD.2017.0717-113
  doi: 10.1002/ana.10079
– ident: key-10.14336/AD.2017.0717-126
  doi: 10.1111/j.1600-0404.2009.01253.x
– ident: key-10.14336/AD.2017.0717-15
  doi: 10.1073/pnas.92.19.8856
– ident: key-10.14336/AD.2017.0717-38
  doi: 10.1016/j.jneuroim.2007.10.013
– ident: key-10.14336/AD.2017.0717-13
  doi: 10.1038/361031a0
– ident: key-10.14336/AD.2017.0717-103
  doi: 10.1002/mds.20491
– ident: key-10.14336/AD.2017.0717-85
  doi: 10.1111/ene.12913
– ident: key-10.14336/AD.2017.0717-121
  doi: 10.1016/j.neulet.2003.09.009
– ident: key-10.14336/AD.2017.0717-84
  doi: 10.1371/journal.pone.0061063
– ident: key-10.14336/AD.2017.0717-2
  doi: 10.1038/mp.2015.27
– ident: key-10.14336/AD.2017.0717-109
  doi: 10.1007/s00415-005-0756-5
– ident: key-10.14336/AD.2017.0717-112
  doi: 10.1007/s00415-009-5357-2
– ident: key-10.14336/AD.2017.0717-76
  doi: 10.1056/NEJMoa073493
– ident: key-10.14336/AD.2017.0717-127
  doi: 10.1016/j.neurobiolaging.2005.10.013
– ident: key-10.14336/AD.2017.0717-90
  doi: 10.1016/S1474-4422(03)00308-9
– ident: key-10.14336/AD.2017.0717-128
  doi: 10.1016/j.neuroimage.2012.08.079
– ident: key-10.14336/AD.2017.0717-46
  doi: 10.1126/science.1129663
– ident: key-10.14336/AD.2017.0717-117
  doi: 10.1136/jnnp.2008.154294
– ident: key-10.14336/AD.2017.0717-37
  doi: 10.1016/j.neulet.2005.02.017
– ident: key-10.14336/AD.2017.0717-52
  doi: 10.1159/000336997
– ident: key-10.14336/AD.2017.0717-67
  doi: 10.1073/pnas.91.5.1632
– ident: key-10.14336/AD.2017.0717-93
  doi: 10.1038/nature02621
– ident: key-10.14336/AD.2017.0717-102
  doi: 10.1093/brain/aww200
– ident: key-10.14336/AD.2017.0717-124
  doi: 10.1016/j.jocn.2011.03.015
– ident: key-10.14336/AD.2017.0717-57
  doi: 10.1056/NEJM199304153281507
– ident: key-10.14336/AD.2017.0717-130
  doi: 10.1111/j.1601-183X.2007.00363.x
– ident: key-10.14336/AD.2017.0717-6
  doi: 10.1074/jbc.M008104200
– ident: key-10.14336/AD.2017.0717-32
  doi: 10.1038/mp.2009.24
– ident: key-10.14336/AD.2017.0717-3
  doi: 10.1126/science.2321006
– ident: key-10.14336/AD.2017.0717-123
  doi: 10.1016/j.neulet.2006.12.038
– ident: key-10.14336/AD.2017.0717-111
  doi: 10.1006/exnr.2000.7483
– ident: key-10.14336/AD.2017.0717-60
  doi: 10.1126/science.275.5300.668
– ident: key-10.14336/AD.2017.0717-79
  doi: 10.1016/j.brainres.2008.11.047
– ident: key-10.14336/AD.2017.0717-116
  doi: 10.1016/j.neulet.2016.01.030
– ident: key-10.14336/AD.2017.0717-105
  doi: 10.1159/000077736
– ident: key-10.14336/AD.2017.0717-36
  doi: 10.1002/ajmg.b.20118
– ident: key-10.14336/AD.2017.0717-28
  doi: 10.1101/gr.8.8.769
– ident: key-10.14336/AD.2017.0717-74
  doi: 10.1212/WNL.0000000000000768
– ident: key-10.14336/AD.2017.0717-97
  doi: 10.1038/376775a0
– ident: key-10.14336/AD.2017.0717-101
  doi: 10.1016/j.neurobiolaging.2013.05.006
– ident: key-10.14336/AD.2017.0717-26
  doi: 10.1016/j.parkreldis.2003.12.003
– ident: key-10.14336/AD.2017.0717-78
  doi: 10.1371/journal.pone.0010003
– ident: key-10.14336/AD.2017.0717-9
  doi: 10.1016/0896-6273(91)90273-3
– ident: key-10.14336/AD.2017.0717-125
  doi: 10.1016/j.neulet.2013.12.051
– ident: key-10.14336/AD.2017.0717-115
  doi: 10.1111/j.1468-1331.2009.02706.x
– ident: key-10.14336/AD.2017.0717-107
  doi: 10.1016/j.expneurol.2005.01.026
– ident: key-10.14336/AD.2017.0717-48
  doi: 10.1007/s00406-011-0189-3
– ident: key-10.14336/AD.2017.0717-94
  doi: 10.1016/j.jalz.2007.04.381
– ident: key-10.14336/AD.2017.0717-118
  doi: 10.1016/j.neurobiolaging.2014.08.023
– ident: key-10.14336/AD.2017.0717-22
  doi: 10.1242/jcs.033316
– ident: key-10.14336/AD.2017.0717-50
  doi: 10.1515/CCLM.2011.039
– ident: key-10.14336/AD.2017.0717-12
  doi: 10.1016/S0006-3223(03)00181-1
– ident: key-10.14336/AD.2017.0717-23
  doi: 10.1016/j.bbr.2009.10.022
– ident: key-10.14336/AD.2017.0717-82
  doi: 10.1093/hmg/ddm189
– ident: key-10.14336/AD.2017.0717-39
  doi: 10.1016/j.pathophys.2010.04.005
– ident: key-10.14336/AD.2017.0717-132
  doi: 10.1176/appi.ajp.161.11.1957
– ident: key-10.14336/AD.2017.0717-27
  doi: 10.1038/sj.tpj.6500094
– ident: key-10.14336/AD.2017.0717-35
  doi: 10.1038/sj.mp.4000952
– ident: key-10.14336/AD.2017.0717-11
  doi: 10.1016/S0006-8993(00)02237-X
– ident: key-10.14336/AD.2017.0717-45
  doi: 10.1098/rstb.2006.1894
– ident: key-10.14336/AD.2017.0717-44
  doi: 10.1016/j.jneuroim.2012.01.011
– ident: key-10.14336/AD.2017.0717-47
  doi: 10.1038/mp.2008.80
– ident: key-10.14336/AD.2017.0717-55
  doi: 10.1038/sj.mp.4001799
– ident: key-10.14336/AD.2017.0717-73
– ident: key-10.14336/AD.2017.0717-56
  doi: 10.1093/cercor/bhw020
– ident: key-10.14336/AD.2017.0717-110
  doi: 10.1002/ana.10487
– ident: key-10.14336/AD.2017.0717-119
– ident: key-10.14336/AD.2017.0717-16
  doi: 10.1093/emboj/16.16.4999
– ident: key-10.14336/AD.2017.0717-80
  doi: 10.1111/j.1601-183X.2006.00245.x
– ident: key-10.14336/AD.2017.0717-29
  doi: 10.1146/annurev.genom.2.1.235
– ident: key-10.14336/AD.2017.0717-92
  doi: 10.1111/j.1468-1331.2011.03529.x
– ident: key-10.14336/AD.2017.0717-68
  doi: 10.1016/S0304-3940(01)01830-4
– ident: key-10.14336/AD.2017.0717-20
  doi: 10.1006/exnr.2002.7869
– ident: key-10.14336/AD.2017.0717-24
  doi: 10.1016/j.neulet.2005.07.009
– ident: key-10.14336/AD.2017.0717-71
  doi: 10.1167/iovs.02-1332
– ident: key-10.14336/AD.2017.0717-5
  doi: 10.1016/j.pharmthera.2013.01.004
– ident: key-10.14336/AD.2017.0717-10
  doi: 10.1016/S0304-3940(99)00463-2
– ident: key-10.14336/AD.2017.0717-54
  doi: 10.3389/neuro.09.011.2008
– ident: key-10.14336/AD.2017.0717-61
  doi: 10.1126/science.1066901
– reference: 16054753 - Neurosci Lett. 2005 Oct 14;387(1):11-6
– reference: 11922662 - Exp Neurol. 2002 Apr;174(2):201-14
– reference: 8127857 - Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1632-6
– reference: 25200713 - Neurology. 2014 Sep 9;83(11):1022-4
– reference: 23593393 - PLoS One. 2013 Apr 11;8(4):e61063
– reference: 25444596 - Neurobiol Aging. 2015 Mar;36(3):1605.e1-6
– reference: 2321006 - Science. 1990 Mar 23;247(4949 Pt 1):1446-51
– reference: 20547043 - Pathophysiology. 2011 Feb;18(1):43-52
– reference: 27521573 - Brain. 2016 Oct;139(Pt 10):2766-2777
– reference: 20478698 - Pathophysiology. 2011 Feb;18(1):53-60
– reference: 11840305 - Mol Psychiatry. 2002;7(2):136-7
– reference: 15537879 - J Neurosci. 2004 Nov 10;24(45):10099-102
– reference: 16869232 - Cogn Affect Behav Neurosci. 2006 Mar;6(1):79-85
– reference: 11274343 - Physiol Rev. 2001 Apr;81(2):741-66
– reference: 21290143 - Eur Arch Psychiatry Clin Neurosci. 2011 Aug;261(5):323-9
– reference: 16565926 - Folia Neuropathol. 2006;44(1):12-6
– reference: 20085561 - Acta Neurol Scand. 2010 Jul;122(1):41-5
– reference: 17656372 - Hum Mol Genet. 2007 Nov 15;16(22):2659-68
– reference: 19504537 - Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):235-42
– reference: 12553913 - Cell. 2003 Jan 24;112(2):257-69
– reference: 8467424 - Can J Neurol Sci. 1993 Feb;20(1):17-29
– reference: 15120095 - Parkinsonism Relat Disord. 2004 Jun;10(4):213-9
– reference: 11834836 - Science. 2002 Feb 8;295(5557):1077-9
– reference: 7746496 - Neurosci Lett. 1995 Jan 2;183(1-2):96-9
– reference: 19255578 - Mol Psychiatry. 2010 Aug;15(8):810-5
– reference: 20368992 - PLoS One. 2010 Apr 02;5(4):e10003
– reference: 24475133 - PLoS One. 2014 Jan 27;9(1):e86498
– reference: 24394906 - Neurosci Lett. 2014 Feb 21;561:86-90
– reference: 24523553 - J Neurosci. 2014 Feb 12;34(7):2645-51
– reference: 19538209 - Eur J Neurol. 2009 Nov;16(11):1240-5
– reference: 16343697 - Neurobiol Aging. 2006 Dec;27(12):1834-7
– reference: 11782995 - Ann Neurol. 2002 Jan;51(1):133-6
– reference: 15048661 - Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):122-3
– reference: 8649517 - Nature. 1996 Jun 20;381(6584):706-9
– reference: 14991827 - Ann Neurol. 2004 Mar;55(3):447-8
– reference: 22341604 - J Neuroimmunol. 2012 Mar;244(1-2):107-10
– reference: 22963854 - Neuroimage. 2013 Jan 1;64:290-8
– reference: 18061279 - J Neuroimmunol. 2008 Jan;193(1-2):170-2
– reference: 17229524 - Neurosci Lett. 2007 Mar 19;415(1):59-63
– reference: 15514393 - Am J Psychiatry. 2004 Nov;161(11):1957-66
– reference: 17629449 - Genomics. 2007 Sep;90(3):397-406
– reference: 1432101 - J Neurosci. 1992 Nov;12(11):4391-402
– reference: 16488940 - Br J Ophthalmol. 2006 Mar;90(3):262-7
– reference: 16356643 - Neurosci Lett. 2006 Apr 3;396(3):217-9
– reference: 23041465 - Neuropsychologia. 2012 Dec;50(14):3554-63
– reference: 12849268 - Lancet Neurol. 2003 Feb;2(2):117-27
– reference: 1671712 - Nature. 1991 Feb 21;349(6311):704-6
– reference: 24942931 - Biochim Biophys Acta. 2014 Sep;1842(9):1567-78
– reference: 28507530 - Front Neurol. 2017 May 01;8:159
– reference: 16740142 - Genes Brain Behav. 2007 Mar;6(2):177-83
– reference: 20226873 - Prog Retin Eye Res. 2010 Jul;29(4):249-71
– reference: 15084795 - Dement Geriatr Cogn Disord. 2004;18(1):55-8
– reference: 9305641 - EMBO J. 1997 Aug 15;16(16):4999-5005
– reference: 17660530 - N Engl J Med. 2007 Aug 30;357(9):851-62
– reference: 16183661 - Brain. 2005 Dec;128(Pt 12):2899-910
– reference: 15295589 - Nature. 2004 Aug 5;430(7000):631-9
– reference: 10543986 - Biochem Biophys Res Commun. 1999 Nov 2;264(3):648-51
– reference: 16344533 - Neurology. 2005 Dec 13;65(11):1823-5
– reference: 22922875 - Nat Genet. 2012 Oct;44(10 ):1142-1146
– reference: 21967235 - Eur J Neurol. 2012 Apr;19(4):655-9
– reference: 19525955 - Nat Genet. 2009 Jul;41(7):824-8
– reference: 21338649 - Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):1022-5
– reference: 15375678 - J Neural Transm (Vienna). 2005 May;112(5):703-11
– reference: 15838855 - Mov Disord. 2005 Aug;20(8):1031-3
– reference: 22538247 - Neuropsychobiology. 2012 Jun;65(4):183-7
– reference: 19589373 - Brain Res Bull. 2010 Jan 15;81(1):61-5
– reference: 7638622 - Science. 1995 Aug 18;269(5226):973-7
– reference: 10711692 - Invest Ophthalmol Vis Sci. 2000 Mar;41(3):764-74
– reference: 7651536 - Nature. 1995 Aug 31;376(6543):775-8
– reference: 20400928 - Psychiatr Genet. 2010 Jun;20(3):109-12
– reference: 8421494 - Nature. 1993 Jan 7;361(6407):31-9
– reference: 21143020 - Clin Chem Lab Med. 2011 Feb;49(2):185-9
– reference: 15896483 - Neurosci Lett. 2005 Jun 24;381(3):275-8
– reference: 10867782 - Arch Neurol. 2000 Jun;57(6):846-51
– reference: 15726264 - J Neurol. 2005 Apr;252(4):423-8
– reference: 10454142 - Neurosci Lett. 1999 Jul 23;270(1):45-8
– reference: 11701650 - Annu Rev Genomics Hum Genet. 2001;2:235-58
– reference: 19874854 - Behav Brain Res. 2010 Mar 5;207(2):377-86
– reference: 26830347 - Cereb Cortex. 2016 Apr;26(4):1795-803
– reference: 1889806 - Genomics. 1991 Jul;10(3):558-68
– reference: 11603614 - Neurol Sci. 2001 Apr;22(2):117-39
– reference: 21985169 - Drugs. 2011 Oct 22;71(15):2031-65
– reference: 18977816 - J Neurol Neurosurg Psychiatry. 2009 Feb;80(2):141-4
– reference: 15571060 - Am Fam Physician. 2004 Nov 15;70(10):1935-44
– reference: 9724323 - Genome Res. 1998 Aug;8(8):769-76
– reference: 18472202 - Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1236-42
– reference: 16446742 - Mol Psychiatry. 2006 May;11(5):505-13
– reference: 9005853 - Science. 1997 Jan 31;275(5300):668-70
– reference: 14730194 - Neuropsychobiology. 2004;49(1):10-2
– reference: 20953813 - Neurol Sci. 2011 Feb;32(1):117-23
– reference: 25824305 - Mol Psychiatry. 2015 Aug;20(8):916-30
– reference: 11274073 - Invest Ophthalmol Vis Sci. 2001 Apr;42(5):966-74
– reference: 25624860 - Arch Med Sci. 2014 Dec 22;10(6):1206-13
– reference: 12049172 - Pharmacogenomics J. 2002;2(2):103-10
– reference: 16649215 - Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):387-93
– reference: 9303531 - J Comp Neurol. 1997 Sep 15;386(1):149-60
– reference: 11152678 - J Biol Chem. 2001 Apr 20;276(16):12660-6
– reference: 19260143 - Croat Med J. 2009 Feb;50(1):43-8
– reference: 17427185 - Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):458-62
– reference: 11244490 - Mol Psychiatry. 2001 Jan;6(1):83-6
– reference: 15899246 - Exp Neurol. 2005 Jul;194(1):91-6
– reference: 12842310 - Biol Psychiatry. 2003 Jul 1;54(1):70-5
– reference: 14642442 - Neurosci Lett. 2003 Dec 15;353(1):75-7
– reference: 21300947 - Arch Gen Psychiatry. 2011 Feb;68(2):198-206
– reference: 19156154 - Mol Psychiatry. 2009 Feb;14(2):120-2
– reference: 16046000 - J Neuroimmunol. 2005 Oct;167(1-2):183-5
– reference: 21427129 - Hum Mol Genet. 2011 Jun 15;20(12):2464-71
– reference: 15772739 - J Neurol. 2005 Jul;252(7):833-8
– reference: 14507880 - Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4357-65
– reference: 23348013 - Pharmacol Ther. 2013 May;138(2):155-75
– reference: 21196952 - Acta Neurobiol Exp (Wars). 2010;70(4):454-67
– reference: 17023662 - Science. 2006 Oct 6;314(5796):140-3
– reference: 11031089 - Exp Neurol. 2000 Nov;166(1):127-35
– reference: 19595937 - Alzheimers Dement. 2007 Jul;3(3):186-91
– reference: 19050044 - J Cell Sci. 2009 Jan 1;122(Pt 1):36-43
– reference: 10825501 - Brain Res. 2000 Jun 2;866(1-2):257-61
– reference: 16939974 - Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1545-64
– reference: 8455668 - N Engl J Med. 1993 Apr 15;328(15):1097-106
– reference: 25536045 - PLoS One. 2014 Dec 23;9(12):e115579
– reference: 17973920 - Genes Brain Behav. 2008 Jun;7(4):411-7
– reference: 18958211 - Front Hum Neurosci. 2008 Sep 23;2:11
– reference: 26806863 - Neurosci Lett. 2016 Feb 26;615:88-91
– reference: 11376903 - Neurosci Lett. 2001 Jun 8;305(2):139-42
– reference: 1742020 - Neuron. 1991 Nov;7(5):695-702
– reference: 19847468 - J Neurol. 2010 Apr;257(4):540-5
– reference: 26756166 - Eur J Neurol. 2016 Mar;23 (3):630-40
– reference: 15635706 - Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):1-5
– reference: 19071096 - Brain Res. 2009 Feb 23;1256:123-8
– reference: 16442082 - Biol Psychiatry. 2006 May 1;59(9):812-5
– reference: 23769397 - Neurobiol Aging. 2013 Nov;34(11):2457-64
– reference: 12783434 - Ann Neurol. 2003 Jun;53(6):823
– reference: 7568031 - Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8856-60
– reference: 12666095 - Ann Neurol. 2003;53 Suppl 3:S16-23; discussion S23-5
– reference: 22001244 - J Clin Neurosci. 2011 Dec;18(12):1744-5
SSID ssj0000392393
Score 2.478537
SecondaryResourceType review_article
Snippet Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development, differentiation, and survival in the developing and adult nervous...
SourceID pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 523
SubjectTerms Brain-derived neurotrophic factor
Diagnosis
Genetic aspects
Genetic polymorphisms
Neurodegenerative diseases
Review
Title BDNF Polymorphism: A Review of Its Diagnostic and Clinical Relevance in Neurodegenerative Disorders
URI https://www.ncbi.nlm.nih.gov/pubmed/29896439
https://www.proquest.com/docview/2054927194
https://pubmed.ncbi.nlm.nih.gov/PMC5988606
Volume 9
WOSCitedRecordID wos000434762200017&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2152-5250
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000392393
  issn: 2152-5250
  databaseCode: DOA
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2152-5250
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000392393
  issn: 2152-5250
  databaseCode: M~E
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6FwoELAsojUMIioXIAi_i5NjeTUCFBogqClJu1a69bS60T5VG1HPgj_Flm1rt-pEICJC5RZE9sZ-fzzOzOzLeEvOQ-S0OfeVbGPWmBP44s4QnXcoVwYf6QRz4P1WYTbDoN5_PouNf7aXphLs5YWYaXl9Hyv6oajoGysXX2L9RdXxQOwHdQOnyC2uHzjxT_fjw9wrI2mNTDGOrCitgw6GPnyGYNlk5V2Bm21pHpj_yC7eaqi6AoXyvijkyeKGbqqsRIc3Wu2zFtfGIaHXeyPV9158fMuMfKuiirv70qmuIdTEJUuf9is6r9xKRYfedSVRtM5GlWtBco7LAppKqcx6fPO6ubZjtkqcwcbqxrYXK1bZOjFvTcln31q-Zk7ar9ijvlmhfwXLVPTTzG0j2GHIysLQfDvjxX2kf6eQzJGmdYlygeT0Z-FIYB0rnfdJgfocmc_GgW8IYQWbqRq3lb8ZZv2zdElml99U7Is-v4W5FPtyq3FebM7pI7en5C4wpX90hPlvfJfgyjuji_oodUVQyrVMw-SRFqtA21dzSmFdDoIqcANNoAjQJCqAEarYFGi5JeAxqtgfaAfDv6MBt9tPSmHVYKwffGSoXtcO7nQmTc9fIsyALO8jzKhnnAA-aIkHEhpPCZzDGJHWQ5uIiMpamTcR667kOyVy5K-ZjQaMjtNPcxse14meMLxx4GwpUsD5jgttcnb8y4JqlmtMeNVc4SnNmiRpJ4nKBGEtRInxzW4suKyuV3gs9RSUnViVzbhCTGrWQZpir75JWSQDTBHVOue1nguZFOrSN50JEE4512Tr8wQEjwFFY8lnKxXcPTIHcisyP4m48qYNRPbYDVJ6wDmVoAOeO7Z8riVHHHa0w_-edfPiW3m5f8gOxtVlv5jNxKLzbFejUgN9g8HKiFrYF6XX4B6ePrDg
linkProvider ISSN International Centre
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=BDNF+Polymorphism%3A+A+Review+of+Its+Diagnostic+and+Clinical+Relevance+in+Neurodegenerative+Disorders&rft.jtitle=Aging+and+disease&rft.au=Shen%2C+Ting&rft.au=You%2C+Yuyi&rft.au=Joseph%2C+Chitra&rft.au=Mirzaei%2C+Mehdi&rft.date=2018-06-01&rft.pub=JKL+International+LLC&rft.eissn=2152-5250&rft.volume=9&rft.issue=3&rft.spage=523&rft.epage=536&rft_id=info:doi/10.14336%2FAD.2017.0717&rft_id=info%3Apmid%2F29896439&rft.externalDocID=PMC5988606
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2152-5250&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2152-5250&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2152-5250&client=summon