The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal loads in oxidative stress molecules may overwhelm the placental defense mechanisms and cause pathological situations. The environment in which the mother evolves triggers an exposure of the placental tissue to che...

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Bibliographic Details
Published in:Antioxidants Vol. 11; no. 1; p. 106
Main Authors: Ruano, Camino San Martin, Miralles, Francisco, Méhats, Céline, Vaiman, Daniel
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01.01.2022
MDPI
Subjects:
Angiogenesis
Antioxidants
DNA methylation
environmental pollution
Females
Fetuses
heavy metals
Human health and pathology
humans
Hypoxia
Kinases
Life Sciences
Mitochondria
Oxidative stress
P38MAPK
Placenta
placental diseases
Pollutants
Pregnancy
Reproductive Biology
Review
Senescence
Sexual reproduction
Tissues and Organs
Vascular endothelial growth factor
Veins & arteries
Vitamins
Womens health
heavy metals
P38MAPK
hypertensive disorders of pregnancy
environmental pollution
DNA methylation
placental diseases
placenta
ISSN:2076-3921, 2076-3921
Online Access:Get full text
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Summary:Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal loads in oxidative stress molecules may overwhelm the placental defense mechanisms and cause pathological situations. The environment in which the mother evolves triggers an exposure of the placental tissue to chemical, physical, and biological agents of OS, with potential pathological consequences. Here we shortly review the physiological and developmental functions of OS in the placenta, and present a series of environmental pollutants inducing placental oxidative stress, for which some insights regarding the underlying mechanisms have been proposed, leading to a recapitulation of the noxious effects of OS of environmental origin upon the human placenta.
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PMCID: PMC8773163
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox11010106