The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal loads in oxidative stress molecules may overwhelm the placental defense mechanisms and cause pathological situations. The environment in which the mother evolves triggers an exposure of the placental tissue to che...

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Vydáno v:	Antioxidants Ročník 11; číslo 1; s. 106
Hlavní autoři:	Ruano, Camino San Martin, Miralles, Francisco, Méhats, Céline, Vaiman, Daniel
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 01.01.2022 MDPI
Témata:	Angiogenesis Antioxidants DNA methylation environmental pollution Females Fetuses heavy metals Human health and pathology humans Hypoxia Kinases Life Sciences Mitochondria Oxidative stress P38MAPK Placenta placental diseases Pollutants Pregnancy Reproductive Biology Review Senescence Sexual reproduction Tissues and Organs Vascular endothelial growth factor Veins & arteries Vitamins Womens health heavy metals P38MAPK hypertensive disorders of pregnancy environmental pollution DNA methylation placental diseases placenta
ISSN:	2076-3921, 2076-3921
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal loads in oxidative stress molecules may overwhelm the placental defense mechanisms and cause pathological situations. The environment in which the mother evolves triggers an exposure of the placental tissue to chemical, physical, and biological agents of OS, with potential pathological consequences. Here we shortly review the physiological and developmental functions of OS in the placenta, and present a series of environmental pollutants inducing placental oxidative stress, for which some insights regarding the underlying mechanisms have been proposed, leading to a recapitulation of the noxious effects of OS of environmental origin upon the human placenta.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 PMCID: PMC8773163
ISSN:	2076-3921 2076-3921
DOI:	10.3390/antiox11010106