Emergence of cefiderocol resistance during therapy in NDM-5–producing Klebsiella pneumoniae isolates harboring siderophore receptors mutations

•Cefiderocol resistance occurred during treatment of an NDM-5 Klebsiella pneumoniae.•Simultaneous resistance emerged by two isogenic isolates with varying cirA mutations.•One isolate harbored mutations in two siderophores receptor genes (cirA and fiu).•Cefiderocol susceptibility testing remains chal...

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Bibliographic Details
Published in:	International journal of infectious diseases Vol. 151; p. 107321
Main Authors:	Deroche, Luc, Rozenholc, Albane, Arrivé, François, Martellosio, Jean-Philippe, Moal, Gwenaël Le, Thille, Arnaud W., Barraud, Olivier, Marchand, Sandrine, Buyck, Julien M.
Format:	Journal Article
Language:	English
Published:	Canada Elsevier Ltd 01.02.2025 Elsevier
Subjects:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotic resistance Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism beta-Lactamases - metabolism Cefiderocol Cefiderocol - pharmacology Cefiderocol - therapeutic use Cephalosporins - pharmacology Cephalosporins - therapeutic use Drug Resistance, Multiple, Bacterial - genetics Humans Klebsiella Infections - drug therapy Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Life Sciences Microbial Sensitivity Tests Mutation Receptors, Cell Surface - genetics Siderophore receptor Siderophores - pharmacology Siderophores - therapeutic use WGS Whole Genome Sequencing WGS Cefiderocol Siderophore receptor Klebsiella pneumoniae Antibiotic resistance
ISSN:	1201-9712, 1878-3511, 1878-3511
Online Access:	Get full text
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