Tissue-specific stem cells: lessons from the skeletal muscle satellite cell

In 1961, the satellite cell was first identified when electron microscopic examination of skeletal muscle demonstrated a cell wedged between the plasma membrane of the muscle fiber and the basement membrane. In recent years it has been conclusively demonstrated that the satellite cell is the primary...

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Bibliographic Details
Published in:Cell stem cell Vol. 10; no. 5; p. 504
Main Authors: Brack, Andrew S, Rando, Thomas A
Format: Journal Article
Language:English
Published: United States 04.05.2012
Subjects:
Adult Stem Cells - physiology
Animals
Cell Division
Guided Tissue Regeneration
Humans
Organ Specificity
Regenerative Medicine - trends
Satellite Cells, Skeletal Muscle - physiology
Signal Transduction
Wound Healing
ISSN:1875-9777, 1875-9777
Online Access:Get more information
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Summary:In 1961, the satellite cell was first identified when electron microscopic examination of skeletal muscle demonstrated a cell wedged between the plasma membrane of the muscle fiber and the basement membrane. In recent years it has been conclusively demonstrated that the satellite cell is the primary cellular source for muscle regeneration and is equipped with the potential to self renew, thus functioning as a bona fide skeletal muscle stem cell (MuSC). As we move past the 50(th) anniversary of the satellite cell, we take this opportunity to discuss the current state of the art and dissect the unknowns in the MuSC field.
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ISSN:1875-9777
1875-9777
DOI:10.1016/j.stem.2012.04.001