TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase

Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that the severity of CS-induced emphysema and COPD is reduced in T...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 7349 - 24
Main Authors:	Liu, Gang, Haw, Tatt Jhong, Starkey, Malcolm R., Philp, Ashleigh M., Pavlidis, Stelios, Nalkurthi, Christina, Nair, Prema M., Gomez, Henry M., Hanish, Irwan, Hsu, Alan CY, Hortle, Elinor, Pickles, Sophie, Rojas-Quintero, Joselyn, Estepar, Raul San Jose, Marshall, Jacqueline E., Kim, Richard Y., Collison, Adam M., Mattes, Joerg, Idrees, Sobia, Faiz, Alen, Hansbro, Nicole G., Fukui, Ryutaro, Murakami, Yusuke, Cheng, Hong Sheng, Tan, Nguan Soon, Chotirmall, Sanjay H., Horvat, Jay C., Foster, Paul S., Oliver, Brian GG, Polverino, Francesca, Ieni, Antonio, Monaco, Francesco, Caramori, Gaetano, Sohal, Sukhwinder S., Bracke, Ken R., Wark, Peter A., Adcock, Ian M., Miyake, Kensuke, Sin, Don D., Hansbro, Philip M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.11.2023 Nature Publishing Group Nature Portfolio
Subjects:	13/2 13/51 14/35 38/77 45/90 49/61 631/250/24/2510 631/250/256/2515 631/250/262/2106/2108 692/699/1785/4037 Animal models Animals Chronic obstructive pulmonary disease Cigarette smoke Cigarettes Emphysema Humanities and Social Sciences Humans Imiquimod Immune system Inhalation Innate immunity Lung Lung diseases Lungs Mast cells Mice Mice, Inbred C57BL Monoclonal antibodies mRNA multidisciplinary Nicotiana Obstructive lung disease Proteins Pulmonary Disease, Chronic Obstructive Pulmonary Emphysema - genetics Respiration RNA viruses Science Science (multidisciplinary) Smoke Therapeutic targets TLR7 protein Toll-Like Receptor 7 - genetics Toll-like receptors Tryptase Tryptases - genetics
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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