Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis

Diphthamide biosynthesis involves a carbon-carbon bond-forming reaction catalyzed by a radical S-adenosylmethionine (SAM) enzyme that cleaves a carbon-sulfur (C-S) bond in SAM to generate a 3-amino-3-carboxypropyl (ACP) radical. Using rapid freezing, we have captured an organometallic intermediate w...

Celý popis

Podrobná bibliografia

Vydané v:	Science (American Association for the Advancement of Science) Ročník 359; číslo 6381; s. 1247
Hlavní autori:	Dong, Min, Kathiresan, Venkatesan, Fenwick, Michael K, Torelli, Andrew T, Zhang, Yang, Caranto, Jonathan D, Dzikovski, Boris, Sharma, Ajay, Lancaster, Kyle M, Freed, Jack H, Ealick, Steven E, Hoffman, Brian M, Lin, Hening
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 16.03.2018
Predmet:	Archaeal Proteins - chemistry Carbon - chemistry Crystallography, X-Ray Histidine - analogs & derivatives Histidine - biosynthesis Iron - chemistry Iron-Sulfur Proteins - chemistry Organometallic Compounds - chemistry Pyrococcus horikoshii - enzymology S-Adenosylmethionine - chemistry
ISSN:	1095-9203, 1095-9203
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!